Weerasak Muangpaisan, Puvanant Wiputhanuphongs, Nattapon Jaisupa, Sarawut Junnu, Jutima Samer, Primchanien Moongkarndi, Orawan Supapueng, Chalobol Chalermsri, Neelobol Neungton
Abstract
Introduction: The water-soluble mangosteen pericarp extract’s (WME) effect was investigated in Alzheimer’s disease (AD).
Methods: The participants received 4 mg/kg/day of WME for 24 weeks (low dose, n = 33), 4 mg/kg/day for 12 weeks and then 8 mg/kg/day for 12 weeks (high dose, n = 33); or a placebo (n = 42). The outcomes were neuropsychiatric test scores, safety, tolerability, and the blood 4-hydroxynonenal level.
Results: The proportion of participants who achieved the minimum clinically important difference for the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog; -2.6 points) at 24 weeks was significantly higher in the low-dose group (and a trend in the high-dose group) than in the placebo group. WME appeared safe and well tolerated. At 24 weeks, the 4-hydroxynonenal level declined in both intervention groups. The participants with a 5% reduction in this level showed greater ADAS-Cog improvements.
Conclusion: WME is a safe and well-tolerated cognitive enhancer in AD with varying benefits across individuals based on antioxidative response.
