ผศ.ดร.นพ. ชยานนท์ พีระพิทยมงคล

  • วท.บ. (วิทยาศาสตร์การแพทย์ เกียรตินิยมอันดับ 1) คณะวิทยาศาสตร์ มหาวิทยาลัยมหิดล
  • พ.บ. (เกียรตินิยม เหรียญทองแดงจุลชีววิทยา) คณะแพทยศาสตร์ศิริราชพยาบาล มหาวิทยาลัยมหิดล
  • Division of Genetics, International Center for Medical Research, Kobe University, JAPAN (Monbusho scholarship)
  • Ph.D. (Biochemistry) คณะวิทยาศาสตร์ มหาวิทยาลัยมหิดล
  • Postdoctoral fellowship (INSERM), Institut Pasteur, Paris, France

Office : 1010 อาคารศรีสวรินทิรา ชั้น 10 ภาควิชาชีวเคมี คณะแพทยศาสตร์ศิริราชพยาบาล โรงพยาบาลศิริราช, เขตบางกอกน้อย, กรุงเทพฯ 10700

Laboratory : 918 อาคารศรีสวรินทิรา ชั้น 9

Phone : (02) 419-9143

E-Mail : chayanon.pee@mahidol.ac.th

งานวิจัย

การศึกษาค้นหาคุณลักษณะที่มีปัจจัยหลายๆปัจจัยเกี่ยวข้องทั้งยีนและสิ่งแวดล้อม โดยเน้นในเรื่องของยีน และปฏิสัมพันธ์ระหว่างยีนกับสิ่งแวดล้อม ในปัจจุบันกำลังศึกษาเรื่องยีนและปัจจัยที่เกี่ยวข้องกับ การสังเคราะห์เฮโมโกลบินเอฟในผู้ป่วยธาลัสซีเมียชนิดเบต้า ซึ่งจาการวิจัยพบว่า อายุน้อย และเพศหญิงมีความสัมพันธ์กับระดับเฮโมโกลบินเอฟที่สูง ในส่วนของพันธุกรรมพบว่ามียีนที่เกี่ยวข้อง ในบริเวณเดียวกับเบต้าโกลบินยีนบนโครโมโซม 11, ช่วงระหว่างยีน MYB-HBS1L บนโครโมโซม 6, ยีน BCL11a บนโครโมโซม 2, และตำแหน่งบนโครโซม 8 และ X ซึ่งยังไม่ทราบต่ำแหน่งและยีนที่แน่ชัด โครงการที่เพิ่งจะเริ่มคือการศึกษายีนที่กำหนดการสร้างโปรตีน aggrecan ซึ่งเป็นโปรตีนที่มีส่วนเติมหมู่น้ำตาลได้มากน้อยแตกต่างกันไป กับความเสี่ยงในการเกิดโรคข้อเสื่อมในผู้สูงอายุ

1. Peerapittayamongkol, C., Bernini, LF., Wilairat, P. (1996) Presence of aCS-globin on membrane of red cells containing hemoglobin Constant Spring (CS).  J Sci Soc Thailand 1996;22:117-20.
2. Laosombat, V., Dissaneevate, S., Peerapittayamongkol, C., & Matsuo, M. (1999). Neonatal hyperbilirubinemia associated with Southeast Asian ovalocytosis.American journal of hematology, 60(2), 136–139. https://doi.org/10.1002/(sici)1096-8652(199902)60:2<136::aid-ajh9>3.0.co;2-e
3. Pongrapeeporn, K.- upsorn S. ., Peerapittayamongkol, C. ., Masaratana, P. ., Krittayaphong, R. ., & Jirapinyo, P. (2005). Identification of Known Mutation in LDL Receptor Gene Underlying Severe FH Phenotype in Thai Patient: A Case Report. Siriraj Medical Journal, 57(11), 501–503. retrieved from https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/245635
4. Chumpia, W., Peerapittayamongkol, C., Angchaisuksiri, P., Komanasin, N., Muta, K., Kuaha, K., Iida, H., Inoue, S., Wada, Y., Kurihara, M., Hamasaki, N., & Fucharoen, S. (2006). Single nucleotide polymorphisms and haplotypes of protein C and protein S genes in the Thai population.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 17(1), 13–18. https://doi.org/10.1097/01.mbc.0000198051.27387.a3
5. Peerapittayamongkol, C., Srisawat, C., Junnu, S., Kanyok, S., Soi-ampornkul, R., Poonsawas, I., & Neungton, N. (2008) Porphyrias diagnosed types by HPLC analysis: 10 years Siriraj experience. Siriraj Med J 2007;59:356-60.
6. Sakuntabhai, A., Ndiaye, R., Casadémont, I., Peerapittayamongkol, C., Rogier, C., Tortevoye, P., Tall, A., Paul, R., Turbpaiboon, C., Phimpraphi, W., Trape, J. F., Spiegel, A., Heath, S., Mercereau-Puijalon, O., Dieye, A., & Julier, C. (2008). Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal. PloS one, 3(4), e2000. https://doi.org/10.1371/journal.pone.0002000
7. Phimpraphi, W., Paul, R., Witoonpanich, B., Turbpaiboon, C., Peerapittayamongkol, C., Louicharoen, C., Casademont, I., Tungpradabkul, S., Krudsood, S., Kaewkunwal, J., Sura, T., Looareesuwan, S., Singhasivanon, P., & Sakuntabhai, A. (2008). Heritability of P. falciparum and P. vivax malaria in a Karen population in Thailand.PloS one, 3(12), e3887. https://doi.org/10.1371/journal.pone.0003887
8. Pandit, R. A., Svasti, S., Sripichai, O., Munkongdee, T., Triwitayakorn, K., Winichagoon, P., Fucharoen, S., & Peerapittayamongkol, C. (2008). Association of SNP in exon 1 of HBS1L with hemoglobin F level in beta0-thalassemia/hemoglobin E. International journal of hematology, 88(4), 357–361. https://doi.org/10.1007/s12185-008-0167-3
9. Louicharoen, C., Patin, E., Paul, R., Nuchprayoon, I., Witoonpanich, B., Peerapittayamongkol, C., Casademont, I., Sura, T., Laird, N. M., Singhasivanon, P., Quintana-Murci, L., & Sakuntabhai, A. (2009). Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians.Science (New York, N.Y.), 326(5959), 1546–1549. https://doi.org/10.1126/science.1178849
10. Panya, A., Sawasdee, N., Srisawat, C., Yenchitsomanus, P., & Peerapittayamongkol, C. (2010)Expression of zinc finger and homeobox 2 in erythroleukaemic cells and gamma-globin expression. ScienceAsia 2010;36:342-5.
11. Lawaly, Y. R., Sakuntabhai, A., Marrama, L., Konate, L., Phimpraphi, W., Sokhna, C., Tall, A., Sarr, F. D., Peerapittayamongkol, C., Louicharoen, C., Schneider, B. S., Levescot, A., Talman, A., Casademont, I., Menard, D., Trape, J. F., Rogier, C., Kaewkunwal, J., Sura, T., Nuchprayoon, I., … Paul, R. (2010). Heritability of the human infectious reservoir of malaria parasites. PloS one, 5(6), e11358. https://doi.org/10.1371/journal.pone.0011358
12. Phasukkijwatana, N., Kunhapan, B., Stankovich, J., Chuenkongkaew, W. L., Thomson, R., Thornton, T., Bahlo, M., Mushiroda, T., Nakamura, Y., Mahasirimongkol, S., Tun, A. W., Srisawat, C., Limwongse, C., Peerapittayamongkol, C., Sura, T., Suthammarak, W., & Lertrit, P. (2010). Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand. Human genetics, 128(1), 39–49. https://doi.org/10.1007/s00439-010-0821-8
13. Moongkarndi, P., Srisawat, C., Saetun, P., Jantaravinid, J., Peerapittayamongkol, C., Soi-ampornkul, R., Junnu, S., Sinchaikul, S., Chen, S. T., Charoensilp, P., Thongboonkerd, V., & Neungton, N. (2010). Protective effect of mangosteen extract against beta-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells. Journal of proteome research, 9(5), 2076–2086. https://doi.org/10.1021/pr100049v
14. Nuinoon, M., Makarasara, W., Mushiroda, T., Setianingsih, I., Wahidiyat, P. A., Sripichai, O., Kumasaka, N., Takahashi, A., Svasti, S., Munkongdee, T., Mahasirimongkol, S., Peerapittayamongkol, C., Viprakasit, V., Kamatani, N., Winichagoon, P., Kubo, M., Nakamura, Y., & Fucharoen, S. (2010). A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.Human genetics, 127(3), 303–314. https://doi.org/10.1007/s00439-009-0770-2
15. Srisawat, C., Junnu, S., Peerapittayamongkol, C., Futrakul, A., Soi-ampornkul, R., Senanarong, V., Praditsuwan, R., Assantachai, P., & Neungton, N. (2013). The platelet amyloid precursor protein ratio as a diagnostic marker for Alzheimer's disease in Thai patients. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 20(5), 644–648. https://doi.org/10.1016/j.jocn.2012.06.008
16. Tun, A. W., Chaiyarit, S., Kaewsutthi, S., Katanyoo, W., Chuenkongkaew, W., Kuwano, M., Tomonaga, T., Peerapittayamongkol, C., Thongboonkerd, V., & Lertrit, P.(2014). Profiling the mitochondrial proteome of Leber's Hereditary Optic Neuropathy (LHON) in Thailand: down-regulation of bioenergetics and mitochondrial protein quality control pathways in fibroblasts with the 11778G>A mutation. PloS one, 9(9), e106779. https://doi.org/10.1371/journal.pone.0106779
17. Chalerm, J., Chowdhury, M. A., Peerapittayamongkol, C., Paiboonsukwong, K., Fucharoen, S., & Sripichai, O. (2017). Influence of single nucleotide polymorphisms in the BCL11A, HBS1L-MYB intergenic region, and HBB gene cluster on the fetal hemoglobin levels in Bangladeshi patients with β-thalassemia/hemoglobin E disease. Genomics and Genetics, 10(1&2), 21–26. https://doi.org/10.14456/gag.2017.4
18. Munkongdee, T., Tongsima, S., Ngamphiw, C., Wangkumhang, P., Peerapittayamongkol, C., Hashim, H. B., Fucharoen, S., & Svasti, S. (2021). Predictive SNPs for β0-thalassemia/HbE disease severity.Scientific reports, 11(1), 10352. https://doi.org/10.1038/s41598-021-89641-2
19. Panusatid, C., Thangsiriskul, N., & Peerapittayamongkol, C. (2022). Methods for mitochondrial health assessment by High Content Imaging System. MethodsX, 9, 101685. https://doi.org/10.1016/j.mex.2022.101685
20. Chumchuen, S., Sripichai, O., Jearawiriyapaisarn, N., Fucharoen, S., & Peerapittayamongkol, C.(2023). Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in β0-thalassemia/HbE erythroid cells. PloS one, 18(3), e0281059. https://doi.org/10.1371/journal.pone.0281059
21. Panusatid, C., Soiyangsuk, R., Tanadjindarat, M., & Peerapittayamongkol, C. (2025). Metformin promotes mitochondrial integrity through AMPK-signaling in Leber’s hereditary optic neuropathy.
FEBS Open Bio. https://doi.org/10.1002/2211-5463.70165

1.

Moongkarndi P, Srisawat C, Saetun P, Jantaravinid J, Peerapittayamongkol C, Soi-ampornkul R, Junnu S, Sinchaikul S, Chen ST, Charoensilp P, Thongboonkerd V, Neungton N. Protective effect of mangosteen extract against beta-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells. มหกรรมสมุนไพรแห่งชาติครั้งที่ 8, 31 สิงหาคม – 4 กันยายน 2554, อิมแพค เมืองทองธานี นนทบุรี.

2.

Peerapittayamongkol C, Munkongdee T, Svasti S, Winichagoon P, Fucharoen S. Genetic risk prediction of severity among b0-thalassemia/Hb E patients. Joint Conference in Medical Sciences 2011: Chula-Rama-Siriraj (JCMS2011), June 15-17, 2011 at IMPACT Exhibition and Convention Center, Thailand: 24.

3.

Moongkarndi P, Srisawat C, Saetun P, Jantaravinid J, Peerapittayamongkol C, Soi-ampornkul R, et al. Protective effect of mangosteen extract against beta-amyloid-induced cytotoxicity, oxidative stress and altered proteome in SK-N-SH cells. Joint Conference in Medical Sciences 2011: Chula-Rama-Siriraj (JCMS2011), June 15-17, 2011 at IMPACT Exhibition and Convention Center, Thailand: 18.

4.

Peerapittayamongkol C, Munkongdee T,Svasti S, Winichagoon P, Fucharoen S. Dense SNP association study of chromosome 6q23 region linked to fetal hemoglobin production in beta0-thalassemia/HbE patients. Mahidol-Kyoto Universities International Symposium 2010, “The integration of Bioscience for Innovative Medicine” December 16-17, 2010 Faculty of Medicne Siriraj Hospital, Mahidol University, Thailand.

5.

Panya A, Srisawat C, Sawasdee N, Yenchitsomanus PT, Peerapittayamongkol C. Human zinc finger and homeodomain 2 (ZHX2) and g-globin expression in erythroleukemic cell line. The 1st CMU Graduate Research Conference, November 27-28, 2009 at Chiang Mai University, Chiang Mai, Thailand.

6.

Neungton N, Moongkarndi P, Srisawat C, Jantaravinid J, Peerapittayamongkol C, Soiampornkul R, et al. Protective effect of mangosteen extract against beta-amyloid-induced apoptosis in SK-N-SH cells. Alzheimer’s&dementia J 2009;5:413-4.

7.

Tirawanchai N, Chanarat N, Somkasetrin A, Chanchairujira T, Srisawat C, Peerapittayamongkol C, et al. Study on the association of C677T and A1298C polymorphisms of the gene encoding methylenetetrahydrofolate reductase (MTHFR) enzyme and plasma homocysteine level in That hemodialysis patients. 33rd FEBS Congree & 11th IUBMB Conference. June 28-July 3, 2008 at Athens, Greece.

8.

Peerapittayamongkol C. Haplotype effect of HBSIL gene in the region of chromosome 6q23 associated with hemoglobin concentreation and fetal hemoglobin levels in Thalassermia patients. Presented in the Joint 7th HUGO Pacific meeting and the 8 th Asia Pacific Human Genetics Conference. April 2-5, 2008 at Cebu, Philippines.

9.

Neungton N, Srisawat C, Junnu S, Peerapittayamongkol C, Fitrakul A, Soiampornkul R, et al. Platelet amyloid precursor protien ratio as a diagmostic marker for Alzheimer’s Disease in Thai patients. A preliminary report [Abstract]. Presented in The 10thInternational Conference on Alzheimer’s Disease and related Disorder July 15-20, 2006 at IFEMA exhibition center Madrid, Spain. Alzheimer’s&dementia J; supplement; 2006;2(2):398.