{"id":4514,"date":"2025-12-17T10:52:15","date_gmt":"2025-12-17T03:52:15","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=4514"},"modified":"2025-12-17T10:53:13","modified_gmt":"2025-12-17T03:53:13","slug":"transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/","title":{"rendered":"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div class=\"title\"><\/div>\n<p class=\"chapter-para\">Sericin, a natural protein derived from Bombyx mori, is known to ameliorate liver tissue damage; however, its molecular mechanism remains unclear. Herein, we aimed to identify the possible novel targets of sericin in hepatocytes and related cellular pathways. RNA sequencing analysis indicated that a low dose of sericin resulted in 18 differentially expressed genes (DEGs) being upregulated and 68 DEGs being downregulated, while 61 DEGs were upregulated and 265 DEGs were downregulated in response to a high dose of sericin (FDR \u2264 0.05, fold change &gt; 1.50). Functional analysis revealed that a low dose of sericin regulated pathways associated with the complement and coagulation cascade, metallothionine, and histone demethylate (HDMs), whereas a high dose of sericin was associated with pathways involved in lipid metabolism, mitogen-activated protein kinase (MAPK) signaling and autophagy. The gene network analysis highlighted twelve genes, A2M, SERPINA5, MT2A, MT1G, MT1E, ARID5B, POU2F1, APOB, TRAF6, HSPA8, FGFR1, and OGT, as novel targets of sericin. Network analysis of transcription factor activity revealed that sericin affects NFE2L2, TFAP2C, STAT1, GATA3, CREB1 and CEBPA. Additionally, the protective effects of sericin depended on the counterregulation of APOB, POU2F1, OGT, TRAF6, and HSPA5. These findings suggest that sericin exerts hepatoprotective effects through diverse pathways at different doses, providing novel potential targets for the treatment of liver diseases.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38443583\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38443583\/<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Sericin, a natural protein derived from Bombyx mori, is known to ameliorate liver tissue damage; however, its molecular mechanism remains unclear. Herein, we aimed to identify the possible novel targets of sericin in hepatocytes and related cellular pathways. RNA sequencing analysis indicated that a low dose of sericin resulted in 18 differentially expressed genes [&#8230;]\n","protected":false},"author":6,"featured_media":4516,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-4514","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-innovation-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"og:description\" content=\"Abstract Sericin, a natural protein derived from Bombyx mori, is known to ameliorate liver tissue damage; however, its molecular mechanism remains unclear. Herein, we aimed to identify the possible novel targets of sericin in hepatocytes and related cellular pathways. RNA sequencing analysis indicated that a low dose of sericin resulted in 18 differentially expressed genes [...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SIBBprogram\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-17T03:52:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-17T03:53:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"749\" \/>\n\t<meta property=\"og:image:height\" content=\"513\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Poorintra Sakuna\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Poorintra Sakuna\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/\"},\"author\":{\"name\":\"Poorintra Sakuna\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/person\/75170c4a414d080cfd0b7428b2e0d11a\"},\"headline\":\"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells\",\"datePublished\":\"2025-12-17T03:52:15+00:00\",\"dateModified\":\"2025-12-17T03:53:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/\"},\"wordCount\":235,\"publisher\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg\",\"articleSection\":[\"Research Innovation\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/\",\"url\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/\",\"name\":\"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\",\"isPartOf\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg\",\"datePublished\":\"2025-12-17T03:52:15+00:00\",\"dateModified\":\"2025-12-17T03:53:13+00:00\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage\",\"url\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg\",\"contentUrl\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg\",\"width\":749,\"height\":513},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#website\",\"url\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/\",\"name\":\"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25 Department of Biochemistry\",\"description\":\"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25\",\"publisher\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#organization\",\"name\":\"Faculty of Medicine Siriraj Hospital, Mahidol University\",\"url\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2023\/10\/logo-01.png\",\"contentUrl\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2023\/10\/logo-01.png\",\"width\":512,\"height\":512,\"caption\":\"Faculty of Medicine Siriraj Hospital, Mahidol University\"},\"image\":{\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/SIBBprogram\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/person\/75170c4a414d080cfd0b7428b2e0d11a\",\"name\":\"Poorintra Sakuna\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c5e900607ffa8b31cad24dc9288ee1a1ee41e9efbb8d1c3094a7d7f3b5c2b78d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c5e900607ffa8b31cad24dc9288ee1a1ee41e9efbb8d1c3094a7d7f3b5c2b78d?s=96&d=mm&r=g\",\"caption\":\"Poorintra Sakuna\"},\"url\":\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/author\/sibc_poorintra\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/","og_locale":"en_US","og_type":"article","og_title":"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25","og_description":"Abstract Sericin, a natural protein derived from Bombyx mori, is known to ameliorate liver tissue damage; however, its molecular mechanism remains unclear. Herein, we aimed to identify the possible novel targets of sericin in hepatocytes and related cellular pathways. RNA sequencing analysis indicated that a low dose of sericin resulted in 18 differentially expressed genes [...]","og_url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/","og_site_name":"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25","article_publisher":"https:\/\/www.facebook.com\/SIBBprogram\/","article_published_time":"2025-12-17T03:52:15+00:00","article_modified_time":"2025-12-17T03:53:13+00:00","og_image":[{"width":749,"height":513,"url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg","type":"image\/jpeg"}],"author":"Poorintra Sakuna","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Poorintra Sakuna","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#article","isPartOf":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/"},"author":{"name":"Poorintra Sakuna","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/person\/75170c4a414d080cfd0b7428b2e0d11a"},"headline":"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells","datePublished":"2025-12-17T03:52:15+00:00","dateModified":"2025-12-17T03:53:13+00:00","mainEntityOfPage":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/"},"wordCount":235,"publisher":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#organization"},"image":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage"},"thumbnailUrl":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg","articleSection":["Research Innovation"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/","url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/","name":"Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25","isPartOf":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage"},"image":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage"},"thumbnailUrl":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg","datePublished":"2025-12-17T03:52:15+00:00","dateModified":"2025-12-17T03:53:13+00:00","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/transcriptomic-screening-of-novel-targets-of-sericin-in-human-hepatocellular-carcinoma-cells\/#primaryimage","url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg","contentUrl":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/41598_2024_56179_Fig1_HTML.jpg","width":749,"height":513},{"@type":"WebSite","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#website","url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/","name":"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25 Department of Biochemistry","description":"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25","publisher":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#organization","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2023\/10\/logo-01.png","contentUrl":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2023\/10\/logo-01.png","width":512,"height":512,"caption":"Faculty of Medicine Siriraj Hospital, Mahidol University"},"image":{"@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/SIBBprogram\/"]},{"@type":"Person","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/person\/75170c4a414d080cfd0b7428b2e0d11a","name":"Poorintra Sakuna","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c5e900607ffa8b31cad24dc9288ee1a1ee41e9efbb8d1c3094a7d7f3b5c2b78d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c5e900607ffa8b31cad24dc9288ee1a1ee41e9efbb8d1c3094a7d7f3b5c2b78d?s=96&d=mm&r=g","caption":"Poorintra Sakuna"},"url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/author\/sibc_poorintra\/"}]}},"_links":{"self":[{"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/posts\/4514","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/comments?post=4514"}],"version-history":[{"count":3,"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/posts\/4514\/revisions"}],"predecessor-version":[{"id":4521,"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/posts\/4514\/revisions\/4521"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/media\/4516"}],"wp:attachment":[{"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/media?parent=4514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/categories?post=4514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/wp-json\/wp\/v2\/tags?post=4514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}