{"id":5153,"date":"2025-12-22T09:03:54","date_gmt":"2025-12-22T02:03:54","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=5153"},"modified":"2026-03-30T15:00:56","modified_gmt":"2026-03-30T08:00:56","slug":"sericin-based-polyvinyl-alcohol-relieves-plaque-and-epidermal-lesions-in-psoriasis-a-chance-for-dressing-development-in-a-specific-area","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/sericin-based-polyvinyl-alcohol-relieves-plaque-and-epidermal-lesions-in-psoriasis-a-chance-for-dressing-development-in-a-specific-area\/","title":{"rendered":"Sericin-Based Poly(Vinyl) Alcohol Relieves Plaque and Epidermal Lesions in Psoriasis; a Chance for Dressing Development in a Specific Area"},"content":{"rendered":"
Khwanchanok Tuentam, Pornanong Aramwit, Onrapak Reamtong, Suangsuda Supasai, Urai Chaisri, Kamonpan Fongsodsri, Rungnapha Yamdech, Napatara Tirawanchai<\/strong>, Passanesh Sukphopetch, Sumate Ampawong<\/p>\n The noncontagious immune-mediated skin disease known as psoriasis is regarded as a chronic skin condition with a 0.09\u201311.4% global prevalence. The main obstacle to the eradication of the disease continues to be insufficient treatment options. Sericin, a natural biopolymer from Bombyx mori cocoons, can improve skin conditions via its immunomodulatory effect. Many external therapeutic methods are currently used to treat psoriasis, but sericin-based hydrogel is not yet used to treat plaques of eczema. Through the use of an imiquimod rat model, this study sought to identify the physical and chemical characteristics of a silk sericin-based poly(vinyl) alcohol (SS\/PVA) hydrogel and assess both its therapeutic and toxic effects on psoriasis. The cytokines, chemokines, and genes involved in the pathogenesis of psoriasis were investigated, focusing on the immuno-pathological relationships. We discovered that the SS\/PVA had a stable fabrication and proper release. Additionally, the anti-inflammatory, antioxidant, and anti-apoptotic properties of SS\/PVA reduced the severity of psoriasis in both gross and microscopic skin lesions. This was demonstrated by a decrease in the epidermal histopathology score, upregulation of nuclear factor erythroid 2-related factor 2 and interleukin (IL)-10, and a decrease in the expression of tumor necrosis factor (TNF)-\u03b1 and IL-20. Moreover, the genes S100a7a and S100a14 were downregulated. Additionally, in rats given the SS\/PVA treatment, blood urea nitrogen, creatinine, and serum glutamic oxaloacetic transaminase levels were within normal limits. Our findings indicate that SS\/PVA is safe and may be potentiated to treat psoriasis in a variety of forms and locations of plaque because of its physical, chemical, and biological characteristics.<\/p>\nAbstract<\/h2>\n