{"id":5165,"date":"2025-12-22T09:14:08","date_gmt":"2025-12-22T02:14:08","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=5165"},"modified":"2026-03-30T14:59:16","modified_gmt":"2026-03-30T07:59:16","slug":"anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\/","title":{"rendered":"Anti-Xanthine Oxidase 5&#8242;-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol"},"content":{"rendered":"\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_527228394\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"810\" height=\"242\" src=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/ao3c07792_0001.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/ao3c07792_0001.jpg 810w, https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/ao3c07792_0001-800x239.jpg 800w, https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/ao3c07792_0001-768x229.jpg 768w\" sizes=\"auto, (max-width: 810px) 100vw, 810px\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_527228394 {\n  width: 100%;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Tawatchai Thongkongkaew, Narumol Jariyasopit, <strong>Sakda Khoomrung<\/strong>, Siraprapa Siritutsoontorn, Sarawut Jitrapakdee, Prasat Kittakoop, Somsak Ruchirawat<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div class=\"title\">\n<p>Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this mushroom is an attractive source of natural products for cancer treatment, little is known about the bioactive compounds from this mushroom, which may possess antibreast cancer activity. Here, we report the isolation and structure elucidation of new compounds, 5&#8242;-hydroxyhericenes A-D (1-4) as an inseparable mixture, together with known compounds (5-16) from the fruiting body of H. erinaceus. Based on NMR spectroscopic data and MS fragmentation analysis, the structure of a previously reported natural product, 3-[2,3-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol (5), should be revised to adenosine (6). Compounds 1-4 inhibit xanthine oxidase activity, while compounds 6, 9, and 10 scavenge reactive oxygen species generated by xanthine oxidase. Moreover, hericerin (13) exhibits strong growth inhibitory activity against T47D breast cancer cells and, to a lesser extent, against MDA-MB-231 breast cancer and MRC-5 normal embryonic cells. Exposure of T47D and MDA-MB-231 cells slightly increased PARP cleavage, suggesting that the growth inhibitory effect of hericerin may be mediated through nonapoptotic pathways. Our results suggest that the bioactive compounds of mushroom H. erinaceus hold promise as antibreast cancer agents.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38075774\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/38075774\/<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Tawatchai Thongkongkaew, Narumol Jariyasopit, Sakda Khoomrung, Siraprapa Siritutsoontorn, Sarawut Jitrapakdee, Prasat Kittakoop, Somsak Ruchirawat Abstract Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this mushroom is an attractive source of natural products for cancer treatment, little is known about the bioactive compounds from this mushroom, which may possess antibreast cancer activity. Here, [&#8230;]\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-5165","post","type-post","status-publish","format-standard","hentry","category-research-innovation-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Anti-Xanthine Oxidase 5&#039;-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anti-Xanthine Oxidase 5&#039;-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"og:description\" content=\"Tawatchai Thongkongkaew, Narumol Jariyasopit, Sakda Khoomrung, Siraprapa Siritutsoontorn, Sarawut Jitrapakdee, Prasat Kittakoop, Somsak Ruchirawat Abstract Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this mushroom is an attractive source of natural products for cancer treatment, little is known about the bioactive compounds from this mushroom, which may possess antibreast cancer activity. Here, [...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SIBBprogram\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-12-22T02:14:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-30T07:59:16+00:00\" \/>\n<meta name=\"author\" content=\"Poorintra Sakuna\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Poorintra Sakuna\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\\\/\"},\"author\":{\"name\":\"Poorintra Sakuna\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/#\\\/schema\\\/person\\\/75170c4a414d080cfd0b7428b2e0d11a\"},\"headline\":\"Anti-Xanthine Oxidase 5&#8242;-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol\",\"datePublished\":\"2025-12-22T02:14:08+00:00\",\"dateModified\":\"2026-03-30T07:59:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\\\/\"},\"wordCount\":231,\"publisher\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/#organization\"},\"articleSection\":[\"Research Innovation\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\\\/\",\"url\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/anti-xanthine-oxidase-5-hydroxyhericenes-a-d-from-the-edible-mushroom-hericium-erinaceus-and-structure-revision-of-3-23-dihydroxy-4-hydroxymethyltetrahydrofuran-1-yl-pyridine-45-diol\\\/\",\"name\":\"Anti-Xanthine Oxidase 5'-Hydroxyhericenes A-D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol - 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\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25","og_description":"Tawatchai Thongkongkaew, Narumol Jariyasopit, Sakda Khoomrung, Siraprapa Siritutsoontorn, Sarawut Jitrapakdee, Prasat Kittakoop, Somsak Ruchirawat Abstract Hericium erinaceus is an edible mushroom with diverse pharmaceutical applications. Although this mushroom is an attractive source of natural products for cancer treatment, little is known about the bioactive compounds from this mushroom, which may possess antibreast cancer activity. 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