{"id":5260,"date":"2026-01-08T11:40:56","date_gmt":"2026-01-08T04:40:56","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=5260"},"modified":"2026-03-30T13:38:11","modified_gmt":"2026-03-30T06:38:11","slug":"higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\/","title":{"rendered":"Higher Plasma Kynurenine to Tryptophan Correlates with an Increased Incidence of Mild Cognitive Impairment in Treated Metabolic Syndrome Patients"},"content":{"rendered":"\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_566332230\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"750\" height=\"575\" src=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2026\/01\/ao5c09713_0001.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2026\/01\/ao5c09713_0001.jpg 750w, https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2026\/01\/ao5c09713_0001-522x400.jpg 522w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_566332230 {\n  width: 100%;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Narumol Jariyasopit, Tiwat Phochmak, Siriphan Manocheewa, Kwanjeera Wanichthanarak, Suphitcha Limjiasahapong, Nichapa Kleebkomut, Yongyut Sirivatanauksorn, <strong>Vorapan Sirivatanauksorn<\/strong>, Arintaya Phrommintikul, Nipon Chattipakorn, Siriporn Chattipakorn,<strong> Sakda Khoomrung<\/strong><\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div class=\"title\">\n<p>An increase in cognitive impairment was observed in metabolic syndrome (MetS) patients. Although alterations in metabolomic profiles have been identified as potential plasma\/serum biomarkers of mild cognitive impairment (MCI) and MetS, findings remain inconsistent\ue5f8probably due to the heterogeneity among MetS patients and the lack of subsequent validation using targeted analysis after the initial untargeted analysis. In this study, we validated mass spectrometry-based quantitation methods and quantified amino acids, fatty acids, and tryptophan metabolites in the kynurenine pathway in the plasma of 95 treated MetS patients with and without MCI assessed by the Montreal Cognitive Assessment. We found that MCI was positively associated with the kynurenine-to-tryptophan ratio (KTR) after the adjustment for age, gender, and BMI, as well as negatively associated with C20:3 [all-Z-8,11,14] and lysine. A one-unit increase in KTR resulted in an increased probability of developing MCI by 371%. In contrast, one-unit increases in C20:3 and lysine were associated with decreased odds of developing MCI by 81 and 78%, respectively. Our finding underscores prominent neuroinflammation, beyond normal aging, in MetS patients, even under ongoing clinical treatment. It also points to the potential of KTR as a risk marker for MCI, offering a valuable complement to the existing cognitive assessments that may be influenced by the educational background. In addition, the validated metabolite data serve as an invaluable resource for future research. They can facilitate comparisons across different studies, contribute to large-scale analyses, and be used in machine learning models for discovering and validating new biomarkers.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41487185\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/41487185\/<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Narumol Jariyasopit, Tiwat Phochmak, Siriphan Manocheewa, Kwanjeera Wanichthanarak, Suphitcha Limjiasahapong, Nichapa Kleebkomut, Yongyut Sirivatanauksorn, Vorapan Sirivatanauksorn, Arintaya Phrommintikul, Nipon Chattipakorn, Siriporn Chattipakorn, Sakda Khoomrung Abstract An increase in cognitive impairment was observed in metabolic syndrome (MetS) patients. Although alterations in metabolomic profiles have been identified as potential plasma\/serum biomarkers of mild cognitive impairment (MCI) and [&#8230;]\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-5260","post","type-post","status-publish","format-standard","hentry","category-research-innovation-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Higher Plasma Kynurenine to Tryptophan Correlates with an Increased Incidence of Mild Cognitive Impairment in Treated Metabolic Syndrome Patients - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Higher Plasma Kynurenine to Tryptophan Correlates with an Increased Incidence of Mild Cognitive Impairment in Treated Metabolic Syndrome Patients - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"og:description\" content=\"Narumol Jariyasopit, Tiwat Phochmak, Siriphan Manocheewa, Kwanjeera Wanichthanarak, Suphitcha Limjiasahapong, Nichapa Kleebkomut, Yongyut Sirivatanauksorn, Vorapan Sirivatanauksorn, Arintaya Phrommintikul, Nipon Chattipakorn, Siriporn Chattipakorn, Sakda Khoomrung Abstract An increase in cognitive impairment was observed in metabolic syndrome (MetS) patients. Although alterations in metabolomic profiles have been identified as potential plasma\/serum biomarkers of mild cognitive impairment (MCI) and [...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SIBBprogram\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-08T04:40:56+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-30T06:38:11+00:00\" \/>\n<meta name=\"author\" content=\"Poorintra Sakuna\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Poorintra Sakuna\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\\\/\"},\"author\":{\"name\":\"Poorintra Sakuna\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/#\\\/schema\\\/person\\\/75170c4a414d080cfd0b7428b2e0d11a\"},\"headline\":\"Higher Plasma Kynurenine to Tryptophan Correlates with an Increased Incidence of Mild Cognitive Impairment in Treated Metabolic Syndrome Patients\",\"datePublished\":\"2026-01-08T04:40:56+00:00\",\"dateModified\":\"2026-03-30T06:38:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\\\/\"},\"wordCount\":297,\"publisher\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/#organization\"},\"articleSection\":[\"Research Innovation\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\\\/\",\"url\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/higher-plasma-kynurenine-to-tryptophan-correlates-with-an-increased-incidence-of-mild-cognitive-impairment-in-treated-metabolic-syndrome-patients\\\/\",\"name\":\"Higher Plasma Kynurenine to Tryptophan Correlates with an Increased Incidence of Mild Cognitive Impairment in Treated Metabolic Syndrome Patients - 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