{"id":5378,"date":"2026-02-25T09:39:04","date_gmt":"2026-02-25T02:39:04","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=5378"},"modified":"2026-03-30T13:22:37","modified_gmt":"2026-03-30T06:22:37","slug":"distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\/","title":{"rendered":"Anti-cancer activity of Kaempferia galanga L.\u2013loaded polydopamine nanoparticles against colorectal cancer"},"content":{"rendered":"<p>Paweena Dana, Anukul Taweechaipaisankul, Yodsathorn Wongngam, Suttipun Sungsuwan, Walailuk Chonniyom, Saksorn Klibaim, Prattana Tanyapanyachon, Monthira Rattanatayarom, Onuma Phoraksa, Udom Asawapirom, <strong>Primana Punnakitikashem<\/strong>, Duangporn Polpanich, Nattika Saengkrit<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div class=\"title\">\n<p>Kaempferia galanga L. (KGL) is an aromatic ginger that has been used as a medicinal plant. Specifically, KGL possesses anti-inflammatory, antioxidant, anti-bacterial, and anti-cancer effects. However, the key component of KGL, ethyl p\u2011methoxy cinnamate (EPMC), is insoluble in water, resulting in low bioavailability. Hence, a nano-drug delivery system is used to enhance KGL activities. This study aimed to employ polydopamine (PDA) nanoparticles as a carrier for KGL delivery to improve its anti-cancer activity against colorectal cancer cells. PDA- and PDA nanoparticle\u2013loaded KGL (PDA-KGL) were synthesized using a spontaneous oxidation process. The physicochemical properties of the PDA-KGL were characterized by dynamic light scattering methods. The anti-cancer activity of PDA-KGL was evaluated in HT-29, a colorectal cancer (CRC) cell line. Average hydrodynamic sizes of PDA and PDA-KGL were 236.2 \u00b1 1.2 and 316.6 \u00b1 2.0 nm, respectively, and the zeta potential of PDA and PDA-KGL were -23.0 \u00b1 0.4 and -39.5 \u00b1 0.6 mV, respectively. The morphology of PDA-KGL observed under TEM was spherical in shape. Anti-proliferative activity was monitored in HT-29 cells using MTT and 3D tumor spheroid assays. PDA-KGL strongly inhibited cell viability of HT-29 cells compared to free KGL and PDA treatments. PDA-KGL induced apoptosis in HT-29 cells as shown by an Annexin V binding assay. In addition, PDA-KGL suppressed the invasive ability of HT-29 cells compared to free KGL or PDA, which was determined by a transwell invasion assay. Taken together, it implies that PDA-KGL might be used as a nano-drug delivery approach for colorectal cancer treatment. \u00a9 2025 The Author(s)<\/p>\n<p><a href=\"https:\/\/www.scopus.com\/pages\/publications\/105001493176?origin=resultslist\">https:\/\/www.scopus.com\/pages\/publications\/105001493176?origin=resultslist<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Paweena Dana, Anukul Taweechaipaisankul, Yodsathorn Wongngam, Suttipun Sungsuwan, Walailuk Chonniyom, Saksorn Klibaim, Prattana Tanyapanyachon, Monthira Rattanatayarom, Onuma Phoraksa, Udom Asawapirom, Primana Punnakitikashem, Duangporn Polpanich, Nattika Saengkrit Abstract Kaempferia galanga L. (KGL) is an aromatic ginger that has been used as a medicinal plant. Specifically, KGL possesses anti-inflammatory, antioxidant, anti-bacterial, and anti-cancer effects. However, the key [&#8230;]\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-5378","post","type-post","status-publish","format-standard","hentry","category-research-innovation-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Anti-cancer activity of Kaempferia galanga L.\u2013loaded polydopamine nanoparticles against colorectal cancer - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anti-cancer activity of Kaempferia galanga L.\u2013loaded polydopamine nanoparticles against colorectal cancer - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"og:description\" content=\"Paweena Dana, Anukul Taweechaipaisankul, Yodsathorn Wongngam, Suttipun Sungsuwan, Walailuk Chonniyom, Saksorn Klibaim, Prattana Tanyapanyachon, Monthira Rattanatayarom, Onuma Phoraksa, Udom Asawapirom, Primana Punnakitikashem, Duangporn Polpanich, Nattika Saengkrit Abstract Kaempferia galanga L. (KGL) is an aromatic ginger that has been used as a medicinal plant. Specifically, KGL possesses anti-inflammatory, antioxidant, anti-bacterial, and anti-cancer effects. However, the key [...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SIBBprogram\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-25T02:39:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-30T06:22:37+00:00\" \/>\n<meta name=\"author\" content=\"Poorintra Sakuna\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Poorintra Sakuna\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\\\/\"},\"author\":{\"name\":\"Poorintra Sakuna\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/#\\\/schema\\\/person\\\/75170c4a414d080cfd0b7428b2e0d11a\"},\"headline\":\"Anti-cancer activity of Kaempferia galanga L.\u2013loaded polydopamine nanoparticles against colorectal cancer\",\"datePublished\":\"2026-02-25T02:39:04+00:00\",\"dateModified\":\"2026-03-30T06:22:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\\\/\"},\"wordCount\":291,\"publisher\":{\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/#organization\"},\"articleSection\":[\"Research Innovation\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\\\/\",\"url\":\"https:\\\/\\\/www2.si.mahidol.ac.th\\\/department\\\/biochemistry\\\/en\\\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\\\/\",\"name\":\"Anti-cancer activity of Kaempferia galanga L.\u2013loaded polydopamine nanoparticles against colorectal cancer - 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(KGL) is an aromatic ginger that has been used as a medicinal plant. Specifically, KGL possesses anti-inflammatory, antioxidant, anti-bacterial, and anti-cancer effects. However, the key [...]","og_url":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/en\/distinct-systemic-immune-responses-in-asymptomatic-and-symptomatic-dengue-virus-infection-5\/","og_site_name":"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25","article_publisher":"https:\/\/www.facebook.com\/SIBBprogram\/","article_published_time":"2026-02-25T02:39:04+00:00","article_modified_time":"2026-03-30T06:22:37+00:00","author":"Poorintra Sakuna","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Poorintra Sakuna","Est. reading time":"2 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