{"id":4767,"date":"2025-12-18T09:34:27","date_gmt":"2025-12-18T02:34:27","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=4767"},"modified":"2026-03-30T09:47:47","modified_gmt":"2026-03-30T02:47:47","slug":"metabolic-and-genetic-risk-factors-associated-with-pre-diabetes-and-type-2-diabetes-in-thai-healthcare-employees-a-long-term-study-from-the-siriraj-health-sih-cohort-study-2","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/metabolic-and-genetic-risk-factors-associated-with-pre-diabetes-and-type-2-diabetes-in-thai-healthcare-employees-a-long-term-study-from-the-siriraj-health-sih-cohort-study-2\/","title":{"rendered":"Metabolic and genetic risk factors associated with pre-diabetes and type 2 diabetes in Thai healthcare employees: A long-term study from the Siriraj Health (SIH) cohort study"},"content":{"rendered":"<p>Pichanun Mongkolsucharitkul, Apinya Surawit, Thamonwan Manosan, Suphawan Ophakas, Sophida Suta, Bonggochpass Pinsawas, Tanyaporn Pongkunakorn, Sureeporn Pumeiam, Winai Ratanasuwan, Mayuree Homsanit, Keerati Charoencholvanich, Yuthana Udomphorn, <strong>Bhoom Suktitipat<\/strong>, Korapat Mayurasakorn<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div class=\"title\">\n<p>Background<br \/>\nThe study of non-communicable diseases (NCDs) in a developing country like Thailand has rarely been conducted in long-term cohorts, especially among the working-age population. We aim to assess the prevalence and incidence of risk factors and their associations underlying NCDs, especially type-2 diabetes mellitus (T2DM) among healthcare workers enrolled in the Siriraj Health (SIH) study cohort.<\/p>\n<p>Methods<br \/>\nThe SIH study was designed as a longitudinal cohort and conducted at Siriraj hospital, Thailand. A total of 5,011 participants (77% women) were recruited and follow-up. Physical examinations, blood biochemical analyses, family history assessments, behavior evaluations, and genetics factors were assessed.<\/p>\n<p>Results<br \/>\nThe average age was 35.44\u00b18.24 years and 51% of participants were overweight and obese. We observed that men were more likely to have a prevalence of T2DM and dyslipidemia (DLP) compared to women. Aging was significantly associated with pre-diabetes and T2DM (P<0.001). Additionally, aging, metabolic syndrome, and elevated triglycerides were associated with the development of pre-diabetes and T2DM. The minor T allele of the rs7903146(C\/T) and rs4506565 (A\/T) were associated with a high risk of developing pre-diabetes with odds ratios of 2.74 (95% confidence interval [CI]: 0.32\u201323.3) and 2.71 (95% CI: 0.32\u201323.07), respectively; however, these associations were statistically insignificant (P>0.05).<\/p>\n<p>Conclusion<br \/>\nThe findings of the SIH study provide a comprehensive understanding of the health status, risk factors, and genetic factors related to T2DM in a specific working population and highlight areas for further research and intervention to address the growing burden of T2DM and NCDs.<\/p>\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11213315\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11213315\/<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Pichanun Mongkolsucharitkul, Apinya Surawit, Thamonwan  [&#8230;]\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-4767","post","type-post","status-publish","format-standard","hentry","category-3"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Metabolic and genetic risk factors associated with pre-diabetes and type 2 diabetes in Thai healthcare employees: A long-term study from the Siriraj Health (SIH) cohort study - \u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25<\/title>\n<meta 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