{"id":5127,"date":"2025-12-19T15:36:59","date_gmt":"2025-12-19T08:36:59","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=5127"},"modified":"2026-03-24T10:45:32","modified_gmt":"2026-03-24T03:45:32","slug":"induction-of-fetal-hemoglobin-lentiviral-shrna-knockdown-of-hbs1l-in-%ce%b20-thalassemia-hbe-erythroid-cells","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/induction-of-fetal-hemoglobin-lentiviral-shrna-knockdown-of-hbs1l-in-%ce%b20-thalassemia-hbe-erythroid-cells\/","title":{"rendered":"Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in \u03b20-thalassemia\/HbE erythroid cells"},"content":{"rendered":"\t<div class=\"img has-hover x md-x lg-x y md-y lg-y\" id=\"image_1246838826\">\n\t\t\t\t\t\t\t\t<div class=\"img-inner dark\" >\n\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"172\" src=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/pone.0281059.g001.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/pone.0281059.g001.jpg 800w, https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/wp-content\/uploads\/2025\/12\/pone.0281059.g001-768x165.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\n<style>\n#image_1246838826 {\n  width: 100%;\n}\n<\/style>\n\t<\/div>\n\t\n<p>Sukanya Chumchuen, Orapan Sripichai, Natee Jearawiriyapaisarn, Suthat Fucharoen, <strong>Chayanon Peerapittayamongkol<\/strong><\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<div class=\"title\">\n<p>Imbalanced globin chain output contributes to thalassemia pathophysiology. Hence, induction of fetal hemoglobin in \u03b2-thalassemia and other \u03b2-hemoglobinopathies are of continuing interest for therapeutic approaches. Genome-wide association studies have identified three common genetic loci: namely \u03b2-globin (HBB), an intergenic region between MYB and HBS1L, and BCL11A underlying quantitative fetal hemoglobin production. Here, we report that knockdown of HBS1L (all known variants) using shRNA in early erythroblast obtained from \u03b20-thalassemia\/HbE patients triggers an upregulation of \u03b3-globin mRNA 1.69 folds. There is modest perturbation of red cell differentiation assessed by flow cytometry and morphology studies. The levels of \u03b1- and \u03b2-globin mRNAs are relatively unaltered. Knockdown of HBS1L also increases the percentage of fetal hemoglobin around 16.7 folds when compared to non-targeting shRNA. Targeting HBS1L is attractive because of the potent induction of fetal hemoglobin and the modest effect on cell differentiation.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36888630\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36888630\/<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sukanya Chumchuen, Orapan Sripichai, Natee Jearawiriyap [&#8230;]\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-5127","post","type-post","status-publish","format-standard","hentry","category-3"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in \u03b20-thalassemia\/HbE erythroid cells - 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\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 \u0e21\u0e2b\u0e32\u0e27\u0e34\u0e17\u0e22\u0e32\u0e25\u0e31\u0e22\u0e21\u0e2b\u0e34\u0e14\u0e25\" \/>\n<meta property=\"og:description\" content=\"Sukanya Chumchuen, Orapan Sripichai, Natee Jearawiriyap [...]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/induction-of-fetal-hemoglobin-lentiviral-shrna-knockdown-of-hbs1l-in-%ce%b20-thalassemia-hbe-erythroid-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0e20\u0e32\u0e04\u0e27\u0e34\u0e0a\u0e32\u0e0a\u0e35\u0e27\u0e40\u0e04\u0e21\u0e35 \u0e04\u0e13\u0e30\u0e41\u0e1e\u0e17\u0e22\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e28\u0e34\u0e23\u0e34\u0e23\u0e32\u0e0a\u0e1e\u0e22\u0e32\u0e1a\u0e32\u0e25 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