{"id":6101,"date":"2026-08-19T15:13:29","date_gmt":"2026-08-19T08:13:29","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/?p=6101"},"modified":"2026-08-19T15:18:50","modified_gmt":"2026-08-19T08:18:50","slug":"patient-ready-syringes-containing-25-mg-ml-methotrexate-can-be-kept-at-temperature-ranging-from-4-c-to-37-c-for-up-to-12-weeks-for-use-in-psoriatic-and-rheumatologic-conditions","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/biochemistry\/patient-ready-syringes-containing-25-mg-ml-methotrexate-can-be-kept-at-temperature-ranging-from-4-c-to-37-c-for-up-to-12-weeks-for-use-in-psoriatic-and-rheumatologic-conditions\/","title":{"rendered":"Patient-ready syringes containing 25 mg\/mL methotrexate can be kept at temperature ranging from 4 \u00b0C to 37 \u00b0C for up to 12 weeks for use in psoriatic and rheumatologic conditions"},"content":{"rendered":"

Leena Chularojanamontri, Chanisada Wongpraparut, Narumol Silpa-Archa, Chayada Chaiyabutr, Chutipon Pruksaeakanan, Anchalika Klinniyom, Sarawut Junnu<\/strong>, Chatchawan Srisawat<\/strong><\/p>\n

Abstract<\/h2>\n
\n
\n

Background: <\/strong> Methotrexate (MTX) is a mainstay drug in the treatment of psoriatic and rheumatologic conditions. Subcutaneous MTX has become a feasible treatment alternative with the development of prefilled syringes or autoinjectors containing MTX solution that can be self-administered by the patient at home. However, MTX prefilled auto-injector pens are still not available in some countries.<\/p>\n

Objective: <\/strong> This study aimed to investigate the stability and sterility of 25 mg\/mL MTX solution in a disposable plastic syringe over a 12-week period under light protection at temperatures of 4 \u00b0C, 25 \u00b0C, and 37 \u00b0C.<\/p>\n

Methods: <\/strong> This study was conducted during November 2019 to February 2020 at the Faculty of Medicine Siriraj Hospital, Mahidol University. Stability was evaluated using ultra-high-performance liquid chromatography technique, and sterility was assessed by cultures for bacterial and fungal contamination.<\/p>\n

Results: <\/strong> Our results revealed that patient-ready syringes containing 25 mg\/mL MTX solution can be prepared in advance and kept for up to 12 weeks under light protection, and they can be kept at temperatures ranging from 4 to 37 \u00b0C.<\/p>\n

Conclusion: <\/strong> This system for delivering MTX to patients that are refractory to or intolerant of oral MTX via a self-administered pre-filled syringe is both efficient and easy to implement in care settings where commercially alternatives are not yet available.<\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/32700608\/<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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