{"id":4063,"date":"2026-05-01T11:47:27","date_gmt":"2026-05-01T04:17:27","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/department\/immunology-dev\/?p=4063"},"modified":"2026-10-02T11:03:50","modified_gmt":"2026-10-02T03:33:50","slug":"limbal-stem-cells-for-corneal-epithelial-restoration","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/department\/immunology\/th\/limbal-stem-cells-for-corneal-epithelial-restoration\/","title":{"rendered":"Limbal stem cells for corneal epithelial restoration"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_section-9c6898a66b27bf239cf5803a8d190352\">\n.avia-section.av-av_section-9c6898a66b27bf239cf5803a8d190352{\nbackground-color:#f0f8ff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-av_section-9c6898a66b27bf239cf5803a8d190352 main_color avia-section-large avia-no-border-styling  avia-builder-el-0  el_before_av_section  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itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h1>Limbal stem cells for corneal epithelial restoration<\/h1>\n<\/div><\/section><\/p><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_section-59befb9af3a8bbc6c4ab76fa605bcb6c\">\n.avia-section.av-av_section-59befb9af3a8bbc6c4ab76fa605bcb6c{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-av_section-59befb9af3a8bbc6c4ab76fa605bcb6c main_color avia-section-large avia-no-border-styling  avia-builder-el-4  el_after_av_section  el_before_av_tab_container  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-4063'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-av_one_fifth-2d22dc0500e159f2b39fe7a147caf14c av_one_fifth  avia-builder-el-5  el_before_av_one_fifth  avia-builder-el-first  first flex_column_div  '     ><\/div><div  class='flex_column av-av_one_fifth-3b0d446bf9e6f7db91541aa567be4cdf av_one_fifth  avia-builder-el-6  el_after_av_one_fifth  el_before_av_three_fifth  flex_column_div  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_image-859826c736dd7dc8606e404801315a39\">\n.avia-image-container.av-av_image-859826c736dd7dc8606e404801315a39 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-av_image-859826c736dd7dc8606e404801315a39 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-av_image-859826c736dd7dc8606e404801315a39 av-styling- av-hover-grow avia-align-center  avia-builder-el-7  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3034 avia-img-lazy-loading-not-3034 avia_image ' src=\"https:\/\/www2.si.mahidol.ac.th\/department\/immunology\/wp-content\/uploads\/2026\/05\/Assist.Prof_.Dr_.Wiwit-Tantibhedhyangkul-M.D.-Ph.D.gif\" alt='Assist.Prof.Dr.Wiwit Tantibhedhyangkul (M.D., Ph.D.)' title='Assist.Prof.Dr.Wiwit Tantibhedhyangkul (M.D., Ph.D.)'  height=\"471\" width=\"481\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div><\/div><div  class='flex_column av-av_three_fifth-3b0d446bf9e6f7db91541aa567be4cdf av_three_fifth  avia-builder-el-8  el_after_av_one_fifth  el_before_av_hr  flex_column_div  '     ><section  class='av_textblock_section av-av_textblock-564067357eb74c20cdd60b282c9b50bd '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><strong>Limbal stem cells for corneal epithelial restoration<\/strong><\/h3>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-av_textblock-564067357eb74c20cdd60b282c9b50bd '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Assist.Prof.Dr.Wiwit Tantibhedhyangkul (M.D., Ph.D.)<\/strong><br \/>\n<strong>Assist.Prof.Dr.Patimaporn Wongprompitak (Ph.D.)<\/strong><\/p>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_hr-0d26c67d8d91c8a850950c746ed41804\">\n#top .hr.hr-invisible.av-av_hr-0d26c67d8d91c8a850950c746ed41804{\nheight:50px;\n}\n<\/style>\n<div  class='hr av-av_hr-0d26c67d8d91c8a850950c746ed41804 hr-invisible  avia-builder-el-11  el_after_av_three_fifth  el_before_av_one_fifth '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<div  class='flex_column av-av_one_fifth-2d22dc0500e159f2b39fe7a147caf14c av_one_fifth  avia-builder-el-12  el_after_av_hr  el_before_av_one_third  first flex_column_div  '     ><\/div><div  class='flex_column av-av_one_third-3b0d446bf9e6f7db91541aa567be4cdf av_one_third  avia-builder-el-13  el_after_av_one_fifth  el_before_av_one_fourth  flex_column_div  '     ><section  class='av_textblock_section av-av_textblock-564067357eb74c20cdd60b282c9b50bd '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>The therapeutic use of limbal or oral epithelial cultures for the regeneration of corneal epithelium in patients with limbal stem cell deficiency (LSCD).<\/p>\n<\/div><\/section><\/div><div  class='flex_column av-av_one_fourth-3b0d446bf9e6f7db91541aa567be4cdf av_one_fourth  avia-builder-el-15  el_after_av_one_third  el_before_av_one_fifth  flex_column_div  '     ><\/div><div  class='flex_column av-av_one_fifth-3b0d446bf9e6f7db91541aa567be4cdf av_one_fifth  avia-builder-el-16  el_after_av_one_fourth  avia-builder-el-last  flex_column_div  '     ><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_2'  class='main_color av_default_container_wrap container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-4063'><div class='entry-content-wrapper clearfix'>\n<div  class='tabcontainer av-av_tab_container-10cfdcbd90dc7524e00ebc8ee65222cb top_tab  avia-builder-el-17  el_after_av_section  avia-builder-el-no-sibling '>\n<section class='av_tab_section av_tab_section av-av_tab-8cbf2c943e6612fe63b90d6b6dcbadbc'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div id='tab-id-1-tab' class='tab active_tab' role='tab' aria-selected=\"true\" tabindex=\"0\" data-fake-id='#tab-id-1' aria-controls='tab-id-1-content'  itemprop=\"headline\" ><span class='tab_icon avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='light-up' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-1' aria-describedby='av-svg-desc-1' role=\"graphics-symbol\">\n<title id='av-svg-title-1'>Light-up<\/title>\n<desc id='av-svg-desc-1'>Light-up<\/desc>\n<path d=\"M30.4 14.72q0.64 0 1.12 0.384t0.48 0.896q0 1.28-1.6 1.28h-1.536q-1.6 0-1.6-1.28 0-0.512 0.48-0.896t1.12-0.384h1.536zM16 7.232q3.648 0 6.24 2.56t2.592 6.208q0 3.712-2.592 6.272t-6.24 2.56-6.208-2.56-2.56-6.272q0-3.648 2.56-6.208t6.208-2.56zM16 22.4q2.624 0 4.512-1.856t1.888-4.544q0-2.624-1.888-4.512t-4.512-1.888-4.512 1.888-1.888 4.512q0 2.688 1.888 4.544t4.512 1.856zM4.8 16q0 1.28-1.6 1.28h-1.6q-1.6 0-1.6-1.28 0-0.512 0.48-0.896t1.12-0.384h1.6q0.64 0 1.12 0.384t0.48 0.896zM16 4.8q-0.512 0-0.896-0.48t-0.384-1.12v-1.6q0-0.64 0.384-1.12t0.896-0.48 0.896 0.48 0.384 1.12v1.6q0 0.64-0.384 1.12t-0.896 0.48zM16 27.2q0.512 0 0.896 0.48t0.384 1.12v1.6q0 0.64-0.384 1.12t-0.896 0.48-0.896-0.48-0.384-1.12v-1.6q0-0.64 0.384-1.12t0.896-0.48zM27.776 6.080l-1.088 1.088q-1.088 1.088-2.048 0.256-0.896-0.896 0.256-2.048 0.128-0.192 1.088-1.152 1.152-1.088 2.048-0.192t-0.256 2.048zM5.376 24.896q0.448-0.512 1.056-0.576t0.928 0.32q0.384 0.384 0.32 0.992t-0.512 1.056l-1.152 1.152q-0.448 0.448-1.056 0.512t-0.928-0.32q-0.96-0.896 0.192-2.048 0.192-0.128 1.152-1.088zM6.016 4.224l1.152 1.152q1.152 1.152 0.192 2.048-0.32 0.32-0.928 0.256t-1.056-0.512q-0.96-0.96-1.152-1.088-0.448-0.448-0.512-1.056t0.32-0.992q0.32-0.384 0.928-0.32t1.056 0.512zM24.896 26.688q-1.152-1.152-0.256-2.048t2.048 0.256l1.088 1.088q1.152 1.152 0.256 2.048t-2.048-0.192q-0.96-0.96-1.088-1.152z\"><\/path>\n<\/svg><\/span>Research Interest<\/div><div id='tab-id-1-content' class='tab_content active_tab_content' role='tabpanel' aria-labelledby='tab-id-1-tab' aria-hidden=\"false\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><p><strong>Brief fields of interest<\/strong><\/p>\n<ul>\n<li>Limbal stem cell deficiency (LSCD) is one of the most challenging eye conditions. Patient with this condition shows a reduced ability to repopulate the corneal and potential vision loss.<\/li>\n<li>Our laboratory activities continue to improve treatment procedures: simple limbal epithelial transplantation (SLET) and cultivated oral mucosal epithelial transplantation (COMET).<\/li>\n<li>We collaborate with multidisciplinary experts in fields such as biomedical engineering and clinical ophthalmology.<\/li>\n<li>Our research projects aim to set up national protocol and guidelines for delivering cultivated corneal epithelium and the treatment of LSCD that are both practical and highly effective for the whole country.<\/li>\n<\/ul>\n<\/div><\/div><\/section>\n<section class='av_tab_section av_tab_section av-av_tab-9c918b36b73e7b16b9ba0951e9e26e1d'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div id='tab-id-2-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-2' aria-controls='tab-id-2-content'  itemprop=\"headline\" ><span class='tab_icon avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='book-open' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"32\" viewBox=\"0 0 29 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-2' aria-describedby='av-svg-desc-2' role=\"graphics-symbol\">\n<title id='av-svg-title-2'>Book-open<\/title>\n<desc id='av-svg-desc-2'>Book-open<\/desc>\n<path d=\"M10.88 19.584v2.176l-6.4-2.56v-2.176zM10.88 12.928v2.176l-6.4-2.56v-2.176zM28.096 1.856q0.704 0.384 0.704 1.344v20.48q0 1.088-1.024 1.472l-12.736 5.12q-0.256 0.064-0.32 0.064t-0.16 0.032-0.16 0.032-0.16-0.032-0.16-0.032l-0.32-0.064-12.736-5.12q-1.024-0.384-1.024-1.472v-20.48q0-0.96 0.704-1.344 0.704-0.512 1.472-0.192l12.224 4.928 12.224-4.928q0.768-0.32 1.472 0.192zM12.8 27.072v-17.92l-10.24-4.096v17.92zM26.24 22.976v-17.92l-10.24 4.096v17.92zM24.32 17.024v2.176l-6.4 2.56v-2.176zM24.32 10.368v2.176l-6.4 2.56v-2.176z\"><\/path>\n<\/svg><\/span>Publications<\/div><div id='tab-id-2-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-2-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><p><strong>Key publications<\/strong><\/p>\n<ul>\n<li>Ekpo P, Inthasin N, Matamnan S, <strong>Wongprompitak P<\/strong>, Wattanapanitch M, Boonwong C, Chirapapaisan C, Ngowyutagon P, Uiprasertkul M, Prabhasawat P, <strong>Tantibhedhyangkul W<\/strong>. Characterization of limbal explant sites: Optimization of stem cell outgrowth in in vitro culture. PLoS One. 2020 May 14;15(5):e0233075.doi: 10.1371\/journal.pone.0233075.<\/li>\n<li>Prabhasawat P, Luangaram A, Ekpo P, Lekhanont K, Tangpagasit W, Boonwong C, Inthasin N, Chirapapaisan C. Epithelial analysis of simple limbal stem cell deficiency by in vivo confocal microscopy and impression cytology. Cell Tissue Bank. 2019 Mar;20(1):95-108. Doi:10.1007\/s10561-018-09746-3.<\/li>\n<li>Prabhasawat P, Chirapapaisan C, Jiravarnsirijul A, Ekpo P, Uiprasertkul M, Thamphithak R, Matamnan S, Boonwong C, Phenotypic Characterization of Corneal Epithelium in Patients With Long-term Follow-up Who Underwent Autologous Cultivated Oral Mucosal Epithelial Transplantation. Cornea. 2020 Oct 19. Doi: 10.1097\/ICO.0000000000002498.<\/li>\n<li>Prabhasawat P, Ekpo P, Uiprasertkul M, Chotikavanich S, Tesavibul N, Pornpanich K, Luemsamran P, Long-term result of autologous cultivated oral mucosal epithelial transplantation for servere ocular surface disease. Cell Tissue Bank. 2016 Sep:17(3):491-503.doi: 10.1007\/s10561-016-9575-4.<\/li>\n<\/ul>\n<\/div><\/div><\/section>\n<section class='av_tab_section av_tab_section av-av_tab-ea3ff4244a67f3b99a793710174bd693'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div id='tab-id-3-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-3' aria-controls='tab-id-3-content'  itemprop=\"headline\" ><span class='tab_icon avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='user' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"30\" height=\"32\" viewBox=\"0 0 30 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-3' aria-describedby='av-svg-desc-3' role=\"graphics-symbol\">\n<title id='av-svg-title-3'>User<\/title>\n<desc id='av-svg-desc-3'>User<\/desc>\n<path d=\"M23.552 23.104q6.528 2.304 6.528 3.904v3.392h-30.080v-3.392q0-1.6 6.528-3.904 3.008-1.088 4.096-2.208t1.088-3.040q0-0.704-0.704-1.568t-1.024-2.336q-0.064-0.384-0.288-0.576t-0.448-0.256-0.448-0.544-0.288-1.376q0-0.512 0.16-0.832t0.288-0.384l0.128-0.128q-0.256-1.6-0.384-2.816-0.128-1.728 1.312-3.584t5.024-1.856 5.056 1.856 1.28 3.584l-0.384 2.816q0.576 0.256 0.576 1.344-0.064 0.896-0.288 1.376t-0.448 0.544-0.448 0.256-0.288 0.576q-0.256 1.536-0.992 2.368t-0.736 1.536q0 1.92 1.12 3.040t4.064 2.208z\"><\/path>\n<\/svg><\/span>People<\/div><div id='tab-id-3-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-3-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><table border=\"0\" cellspacing=\"1\" cellpadding=\"1\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-54343\" src=\"https:\/\/www.si.mahidol.ac.th\/th\/department\/immunology\/admin\/news_images\/501_14_3wrdCqf.png\" alt=\"\" width=\"120\" height=\"20\" \/><br \/>\n<strong>\u0e19.\u0e2a. \u0e13\u0e2b\u0e24\u0e17\u0e31\u0e22 \u0e2d\u0e34\u0e19\u0e15\u0e4a\u0e30\u0e2a\u0e34\u0e19<\/strong><br \/>\n<strong><span class=\"cf0\">Medical Scientist<\/span><\/strong><br \/>\n<strong>(Senior Professional Level)<\/strong><\/td>\n<td style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-54343\" src=\"https:\/\/www.si.mahidol.ac.th\/th\/department\/immunology\/admin\/news_images\/501_14_4yKppaT.png\" alt=\"\" width=\"120\" height=\"20\" \/><br \/>\n<strong>\u0e19\u0e32\u0e22 \u0e23\u0e27\u0e34\u0e20\u0e32\u0e28 \u0e2a\u0e32\u0e22\u0e2a\u0e38\u0e27\u0e23\u0e23\u0e13<\/strong><br \/>\n<strong><span class=\"cf0\">Medical Scientist<\/span><\/strong><\/td>\n<td style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-54343\" src=\"https:\/\/www.si.mahidol.ac.th\/th\/department\/immunology\/admin\/news_images\/503_14_5RMyXLA.png\" alt=\"\" width=\"120\" height=\"20\" \/><br \/>\n<strong>\u0e19.\u0e2a. \u0e13\u0e31\u0e10\u0e27\u0e23\u0e23\u0e13 \u0e02\u0e31\u0e2a\u0e40\u0e01\u0e15\u0e38<\/strong><br \/>\n<strong><span class=\"cf0\">Research Technical Officer<\/span><\/strong><\/td>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-3637\" src=\"https:\/\/www2.si.mahidol.ac.th\/department\/immunology\/wp-content\/uploads\/2026\/07\/Untitled.jpg\" alt=\"\" width=\"120\" height=\"20\" \/><\/td>\n<td><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-3637\" src=\"https:\/\/www2.si.mahidol.ac.th\/department\/immunology\/wp-content\/uploads\/2026\/07\/Untitled.jpg\" alt=\"\" width=\"120\" height=\"20\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/section>\n<section class='av_tab_section av_tab_section av-av_tab-2f9cc96d237002ceadc1e12eead785b3'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div id='tab-id-4-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-4' aria-controls='tab-id-4-content'  itemprop=\"headline\" ><span class='tab_icon avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='mail' data-av_iconset='svg_entypo-fontello'><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"32\" viewBox=\"0 0 29 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-4' aria-describedby='av-svg-desc-4' role=\"graphics-symbol\">\n<title id='av-svg-title-4'>Mail<\/title>\n<desc id='av-svg-desc-4'>Mail<\/desc>\n<path d=\"M0.96 8.448q-1.024-0.576-0.896-1.28 0.064-0.448 0.832-0.448h27.072q1.216 0 0.64 1.024-0.256 0.448-0.768 0.704-0.448 0.192-6.144 3.264t-5.824 3.136q-0.512 0.32-1.472 0.32-0.896 0-1.472-0.32-0.128-0.064-5.824-3.136t-6.144-3.264zM28.16 11.648q0.64-0.32 0.64 0.32v11.776q0 0.512-0.544 1.024t-1.056 0.512h-25.6q-0.512 0-1.056-0.512t-0.544-1.024v-11.776q0-0.64 0.64-0.32l12.288 6.4q0.576 0.32 1.472 0.32t1.472-0.32z\"><\/path>\n<\/svg><\/span>Contact<\/div><div id='tab-id-4-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-4-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><p><strong>Office<\/strong> : Department of Immunology, Faculty of Medicine Siriraj, Hospital, Mahidol University, Bangkok Noi, Bangkok 10700 Thailand<br \/>\n<strong>Laboratory<\/strong> : 11th Floor, Adulyadejvikrom Building<br \/>\n<strong>Phone<\/strong> : +66-2-419-6635<br \/>\n<strong>Fax<\/strong> : +66-2-418-1636<br \/>\n<strong>Email<\/strong> : 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