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โครงการนี้เป็นการศึกษาวิจัยระยะที่ 3 (Phase III) แบบเปิดเผยข้อมูล (open-label) ที่ดำเนินการในหลายศูนย์วิจัย (multi-center) โดยใช้การออกแบบการวิจัยแบบ cluster-randomized superiority ซึ่งกลุ่มตัวอย่าง (cluster) หมายถึงสมาชิกในครอบครัวเดียวกันที่สัมผัสกับผู้ป่วย MDR-TB

วัตถุประสงค์หลัก
เพื่อเปรียบเทียบประสิทธิภาพและความปลอดภัยของยา delamanid กับยา isoniazid ที่ให้ต่อเนื่องเป็นเวลา 26 สัปดาห์ ในการป้องกันการเกิดวัณโรค ภายในระยะเวลาเฝ้าติดตาม 96 สัปดาห์ ในกลุ่มผู้สัมผัสความเสี่ยงสูงที่อาศัยอยู่ในบ้านเดียวกับผู้ป่วย MDR-TB

กลุ่มเป้าหมาย
คาดว่าจะมีผู้เข้าร่วมมากกว่า 3,400 ราย จากประมาณ 1,700 ครัวเรือน (โดยเฉลี่ยมีผู้เข้าร่วม 2 รายต่อบ้าน)

ความร่วมมือ
โครงการนี้เป็นความร่วมมือระหว่างเครือข่าย IMPAACT และ ACTG

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