{"id":50588,"date":"2024-06-17T17:59:46","date_gmt":"2024-06-17T10:29:46","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/en\/?p=50588"},"modified":"2024-06-18T09:03:55","modified_gmt":"2024-06-18T01:33:55","slug":"procyanidin-condensed-tannins-from-kratom-mitragyna-speciosa-as-virucidal-agents-against-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/procyanidin-condensed-tannins-from-kratom-mitragyna-speciosa-as-virucidal-agents-against-sars-cov-2\/","title":{"rendered":"Procyanidin Condensed Tannins from Kratom (Mitragyna speciosa) as Virucidal Agents Against SARS-CoV-2"},"content":{"rendered":"

We are delighted to share the publication of groundbreaking research by Assoc. Prof. Dr. Sakda Khoomrung (co-author) from the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine, Siriraj Hospital, Mahidol University. This research, published in the International Journal of Biological Macromolecules on June 10, 2024, unveils the discovery of virucidal agents against SARS-CoV-2 in Kratom. The publication is available for access via the following link: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813024038649?via%3Dihub<\/a><\/p>\n

This research paper represents a collaboration between the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB) and the Virology and Cell Technology Research Team at the National Center for Genetic Engineering and Biotechnology (BIOTEC) and Chulabhorn Research Institute.<\/strong> Their collaborative efforts were instrumental in advancing our understanding of the virucidal properties of Kratom (Mitragyna speciosa) compounds against SARS-CoV-2.<\/p>\n

Previous studies have primarily focused on bioactive alkaloids in Kratom, but non-alkaloid compounds have yet to be extensively explored for their biological activities. In this study, antiviral and virucidal assays of a methanol leaf extract of Kratom, M. speciosa, demonstrated significant virucidal activity against SARS-CoV-2. Activity-guided isolation of the methanol leaf extract identified B-type procyanidin condensed tannins of (\u2014)-epicatechin as potent virucidal compounds. The fraction containing condensed tannins exhibited virucidal activity with an EC50 value of 8.38 \u03bcg\/mL and a selectivity index (SI) value >23.86. Structural analysis using LC-MS\/MS and MALDI-TOF MS confirmed the presence of B-type procyanidin condensed tannins in Kratom. At the same time, gel permeation chromatography (GPC) revealed an average molecular weight of 238,946 Da for high molecular-weight condensed tannins. Although (\u2014)-epicatechin, a major component in Kratom leaves, did not exhibit virucidal activity, its macromolecules, procyanidin condensed tannins, displayed potent activity against SARS-CoV-2. This finding highlights the significance of high molecular weight polyphenols in the virucidal activity of Kratom compounds.<\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

We are delighted to share the publication of groundbreaking research by Assoc. Prof. Dr. Sakda Khoomrung (co-author) from the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine, Siriraj Hospital, Mahidol University. This research, published in the International Journal of Biological Macromolecules on June 10, 2024, unveils the discovery of […]<\/p>\n","protected":false},"author":109,"featured_media":50589,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,38,204],"tags":[],"class_list":["post-50588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-events","category-research","category-sicore-m"],"_links":{"self":[{"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/posts\/50588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/users\/109"}],"replies":[{"embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/comments?post=50588"}],"version-history":[{"count":0,"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/posts\/50588\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/media\/50589"}],"wp:attachment":[{"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/media?parent=50588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/categories?post=50588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www2.si.mahidol.ac.th\/en\/wp-json\/wp\/v2\/tags?post=50588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}