{"id":61135,"date":"2025-11-25T10:34:03","date_gmt":"2025-11-25T03:34:03","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/en\/?p=61135"},"modified":"2026-02-20T09:15:14","modified_gmt":"2026-02-20T02:15:14","slug":"breakthrough-metabolomics-study-highlights-hidden-gut-toxins-in-peritoneal-dialysis-patients-2","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/breakthrough-metabolomics-study-highlights-hidden-gut-toxins-in-peritoneal-dialysis-patients-2\/","title":{"rendered":"Breakthrough Metabolomics Study Highlights Hidden Gut Toxins in Peritoneal Dialysis Patients"},"content":{"rendered":"<div id='av_section_1'  class='avia-section av-av_section-be5469b648f3c66bc848ea728be917cc main_color avia-section-small avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  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itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/11\/\u0e02\u0e48\u0e32\u0e27-SiCOREs.png 1920w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/11\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-300x169.png 300w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/11\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1030x579.png 1030w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/11\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-768x432.png 768w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/11\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1536x864.png 1536w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/11\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1500x844.png 1500w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/11\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-705x397.png 705w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/div><\/div><\/div><\/div><div  class='flex_column av-av_one_fifth-3b0d446bf9e6f7db91541aa567be4cdf av_one_fifth  avia-builder-el-6  el_after_av_three_fifth  avia-builder-el-last  flex_column_div  '     ><\/div><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_3'  class='avia-section av-av_section-f22f0f9dd672aac3df52cf5913f6ac08 main_color avia-section-default avia-no-border-styling  avia-builder-el-7  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-61135'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-av_one_fifth-2d22dc0500e159f2b39fe7a147caf14c av_one_fifth  avia-builder-el-8  el_before_av_three_fifth  avia-builder-el-first  first flex_column_div  '     ><\/div><div  class='flex_column av-av_three_fifth-3b0d446bf9e6f7db91541aa567be4cdf av_three_fifth  avia-builder-el-9  el_after_av_one_fifth  el_before_av_one_fifth  flex_column_div  '     ><section  class='av_textblock_section av-mie0ikk7-57071ccb03edcbc93ac0f0d9b6c53cc6 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h2>Breakthrough Metabolomics Study Highlights Hidden Gut Toxins in Peritoneal Dialysis Patients<\/h2>\n<\/div><\/section><\/div><div  class='flex_column av-av_one_fifth-3b0d446bf9e6f7db91541aa567be4cdf av_one_fifth  avia-builder-el-11  el_after_av_three_fifth  el_before_av_one_fifth  flex_column_div  '     ><\/div><div  class='flex_column av-av_one_fifth-2d22dc0500e159f2b39fe7a147caf14c av_one_fifth  avia-builder-el-12  el_after_av_one_fifth  el_before_av_three_fifth  first flex_column_div  column-top-margin'     ><\/div><div  class='flex_column av-av_three_fifth-3b0d446bf9e6f7db91541aa567be4cdf av_three_fifth  avia-builder-el-13  el_after_av_one_fifth  el_before_av_one_fifth  flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-mie0jlhy-229c6156f81d0bb6ccdd4ef87ebbd44e '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h2>Congratulations<\/h2>\n<p>Congratulations to Dr. Weerawan Manokasemsan, Dr. Narumol Jariyasopit, Dr. Kwanjeera Wanichthanarak, Asst. Prof. Dr.Sukit Raksasuk, and Assoc. Prof. Dr. Sakda Khoomrung of SiCORE-MSB and SiMPC, Faculty of Medicine Siriraj Hospital, Mahidol University, on their latest publication in the Computational and Structural Biotechnology Journal (November 17, 2025):<br \/>\n\u201cLC-MS\/MS identifies elevated imidazole propionate and gut-derived metabolite alterations in peritoneal dialysis patients.\u201d<\/p>\n<p>Read here <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2001037025005082\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2001037025005082<\/a><\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mie0jzoi-fa4a5e6db58e679b9998d9a6ef464916\">\n#top .av_textblock_section.av-mie0jzoi-fa4a5e6db58e679b9998d9a6ef464916 .avia_textblock{\ncolumn-count:2;\n}\n<\/style>\n<section  class='av_textblock_section av-mie0jzoi-fa4a5e6db58e679b9998d9a6ef464916 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock av_multi_colums'  itemprop=\"text\" ><p><strong> Study Highlights<\/strong><\/p>\n<p>Chronic kidney disease continues to rise worldwide, and many kidney-failure patients rely on peritoneal dialysis (PD). However, new evidence suggests that gut-derived toxins may still accumulate despite treatment\u2014with one metabolite standing out: Imidazole propionate (ImP).<\/p>\n<p>Using a high-sensitivity LC\u2013MS\/MS workflow, the team quantified 16 uremic toxins and 14 bile acids in blood and stool samples simultaneously. One of the most striking findings is that ImP levels are markedly elevated in PD patients, including those without diabetes or cardiovascular disease.<\/p>\n<p>ImP has previously been associated with metabolic dysfunction and cardiovascular risk, but this study reveals that kidney failure itself may drive ImP accumulation, making it a promising candidate as a novel risk marker in CKD.<\/p>\n<p>These insights open the door to improved patient risk stratification and potential future interventions\u2014ranging from dietary modulation and microbiome-based approaches to enhanced dialysis strategies.<\/p>\n<p>The team is now expanding this work into a larger, longitudinal cohort integrating microbiome data to validate ImP and related metabolites as actionable biomarkers.<\/p>\n<p>This achievement reflects 5\u20136 years of sustained collaboration between Siriraj and Ramathibodi.<br \/>\nSpecial thanks to Jia and all team members for their dedication.<\/p>\n<\/div><\/section><\/p><\/div><div 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srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/04\/2026-Qs-subject-No-80x80.jpg 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/04\/2026-Qs-subject-No-36x36.jpg 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/04\/2026-Qs-subject-No-180x180.jpg 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Mahidol University Maintains 12-Year Dominance as Thailand&#039;s Leading Medical Institution\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-04-27T16:23:24+07:00\" >April 27, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/mahidol-university-maintains-12-year-dominance-as-thailands-leading-medical-institution\/' title='Link to: Mahidol University Maintains 12-Year Dominance as Thailand&#8217;s Leading Medical Institution'>Mahidol University Maintains 12-Year Dominance as Thailand&#8217;s Leading Medical Institution<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><article class='av-magazine-entry av-magazine-entry-id-62993 av-magazine-format-standard av-magazine-type-post av-magazine-entry-2 av-magazine-entry-small '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"av-magazine-thumbnail\"><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-international-residents-and-fellows-exchange-program-in-usa\/' title='Link to: Siriraj International Residents and Fellows Exchange Program in USA' class='av-magazine-thumbnail-link'><img decoding=\"async\" fetchpriority=\"high\" width=\"80\" height=\"80\" src=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/2342-80x80.jpg\" class=\"wp-image-62994 avia-img-lazy-loading-not-62994 attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/2342-80x80.jpg 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/2342-36x36.jpg 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/2342-180x180.jpg 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj International Residents and Fellows Exchange Program in USA\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-03-31T13:41:55+07:00\" >March 31, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-international-residents-and-fellows-exchange-program-in-usa\/' title='Link to: Siriraj International Residents and Fellows Exchange Program in USA'>Siriraj International Residents and Fellows Exchange Program in 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srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/IMG_0785_0-80x80.jpg 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/IMG_0785_0-36x36.jpg 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/IMG_0785_0-180x180.jpg 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj International Residents and Fellows Exchange Program in USA\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-03-27T16:44:39+07:00\" >March 27, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-international-residents-and-fellows-exchange-program-in-usa-2\/' title='Link to: Siriraj International Residents and Fellows Exchange Program in USA'>Siriraj International Residents and Fellows Exchange Program in 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srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/S__938205202-e1774515103667-80x80.jpg 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/S__938205202-e1774515103667-36x36.jpg 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/S__938205202-e1774515103667-180x180.jpg 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj Surgeons Present Cutting-Edge Techniques at 2026 SAGES Annual Meeting\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-03-26T15:46:42+07:00\" >March 26, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-surgeons-present-cutting-edge-techniques-at-2026-sages-annual-meeting\/' title='Link to: Siriraj Surgeons Present Cutting-Edge Techniques at 2026 SAGES Annual 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srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/247995_0-80x80.jpg 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/247995_0-36x36.jpg 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/03\/247995_0-180x180.jpg 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Clinical Rotation at Siriraj&#039;s Infectious Diseases\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-03-23T15:24:49+07:00\" >March 23, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/clinical-rotation-at-sirirajs-infectious-diseases-2\/' title='Link to: Clinical Rotation at Siriraj&#8217;s Infectious Diseases'>Clinical Rotation at Siriraj&#8217;s Infectious Diseases<\/a><\/h3><\/header><\/div><footer 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