{"id":61794,"date":"2025-12-12T13:01:38","date_gmt":"2025-12-12T06:01:38","guid":{"rendered":"https:\/\/www2.si.mahidol.ac.th\/en\/?p=61794"},"modified":"2026-02-24T14:06:07","modified_gmt":"2026-02-24T07:06:07","slug":"sicore-msb-researchers-publish-new-insights-on-bile-acid-derived-antiviral-and-antibacterial-agents-in-rsc-advances","status":"publish","type":"post","link":"https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/sicore-msb-researchers-publish-new-insights-on-bile-acid-derived-antiviral-and-antibacterial-agents-in-rsc-advances\/","title":{"rendered":"SiCORE-MSB Researchers Publish New Insights on Bile Acid\u2013Derived Antiviral and Antibacterial Agents in RSC Advances"},"content":{"rendered":"<div id='av_section_1'  class='avia-section av-crjegaq-785a60f9cc5516c0d5df309d059f94c7 main_color avia-section-small avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-bg-style-scroll container_wrap fullsize'  ><div class='container 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el_before_av_one_fifth  flex_column_div  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mj2gin0u-2e98ad2110fa4607115b5d724c768e95\">\n.avia-image-container.av-mj2gin0u-2e98ad2110fa4607115b5d724c768e95 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mj2gin0u-2e98ad2110fa4607115b5d724c768e95 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mj2gin0u-2e98ad2110fa4607115b5d724c768e95 av-styling- avia-align-center  avia-builder-el-5  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-61795 avia-img-lazy-loading-not-61795 avia_image ' src=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1.png\" alt='' title='\u0e02\u0e48\u0e32\u0e27 SiCOREs'  height=\"1080\" width=\"1920\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1.png 1920w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1-300x169.png 300w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1-1030x579.png 1030w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1-768x432.png 768w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1-1536x864.png 1536w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1-1500x844.png 1500w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1-705x397.png 705w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/div><\/div><\/div><\/div><div  class='flex_column av-ad4bzuq-14e9cb64935b111243ce8f52222ce9c0 av_one_fifth  avia-builder-el-6  el_after_av_three_fifth  avia-builder-el-last  flex_column_div  '     ><\/div><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_3'  class='avia-section av-9uv1g02-ce295da6548613707f875acd87aafb8c main_color avia-section-default avia-no-border-styling  avia-builder-el-7  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-61794'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-9ft6uci-5622c11705c0011b81cf50346025611e av_one_fifth  avia-builder-el-8  el_before_av_three_fifth  avia-builder-el-first  first flex_column_div  '     ><\/div><div  class='flex_column av-wlc9j6-f435a8f9d9943c30a8c1f9e38764b50c av_three_fifth  avia-builder-el-9  el_after_av_one_fifth  el_before_av_one_fifth  flex_column_div  '     ><section  class='av_textblock_section av-mj2girc8-f19894726e1bac566682415f404fecca '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>SiCORE-MSB Researchers Publish New Insights on Bile Acid\u2013Derived Antiviral and Antibacterial Agents in <em data-start=\"459\" data-end=\"473\">RSC Advances<\/em><\/strong><\/p>\n<\/div><\/section><\/div><div  class='flex_column av-utxllu-8dc4cc7981eac4485277577025c3bf6a av_one_fifth  avia-builder-el-11  el_after_av_three_fifth  el_before_av_one_fifth  flex_column_div  '     ><\/div><div  class='flex_column av-7xh5bhe-fadb7b67516f5d14523e872b98600292 av_one_fifth  avia-builder-el-12  el_after_av_one_fifth  el_before_av_three_fifth  first flex_column_div  column-top-margin'     ><\/div><div  class='flex_column av-7o60f2a-dcbf00538c47c036caf7baee31c41df6 av_three_fifth  avia-builder-el-13  el_after_av_one_fifth  el_before_av_one_fifth  flex_column_div  column-top-margin'     ><section  class='av_textblock_section av-mj2gjxqy-29ea04c6f28aee592a86df1365d56b0e '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><h2>Congratulations to Assoc. Prof. Dr. Sakda Khoomrung and Collaborators on Their Latest Publication in RSC Advances<\/h2>\n<p>We extend our warmest congratulations to Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University, together with collaborators from Chulabhorn Graduate Institute, BIOTEC, Chulabhorn Royal Academy, Chulabhorn Research Institute, Chulalongkorn University, and the Ministry of Higher Education, Science, Research and Innovation, for their newly accepted publication in RSC Advances (Accepted November 20, 2025):<\/p>\n<p>\u201cAntiviral and virucidal activities against SARS-CoV-2 and antibacterial properties of bile acids and their salts with naturally occurring organic cations L-carnitine, creatinine, and choline.\u201d<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mj2gkd5p-16187980202343ed8195a0e8e2a56ec1\">\n#top .av_textblock_section.av-mj2gkd5p-16187980202343ed8195a0e8e2a56ec1 .avia_textblock{\ncolumn-count:2;\n}\n<\/style>\n<section  class='av_textblock_section av-mj2gkd5p-16187980202343ed8195a0e8e2a56ec1 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock av_multi_colums'  itemprop=\"text\" ><p>Study Highlights<\/p>\n<p>This study explored the antiviral, virucidal, and antibacterial properties of bile acids and their naturally derived salts. Four bile acids: lithocholic acid (LCA), deoxycholic acid (DCA), ursodeoxycholic acid (UDCA), and chenodeoxycholic acid (CDCA) \u2014 were combined with L-carnitine, creatinine, and choline to create salt forms for comparative analysis.<\/p>\n<p>Key findings include:<\/p>\n<ol>\n<li>LCA demonstrated direct virucidal activity against SARS-CoV-2; however, converting LCA into salts did not enhance this antiviral effect.<\/li>\n<li>DCA, UDCA, and CDCA showed broad antibacterial activity against both Gram-positive and Gram-negative bacteria.<\/li>\n<li>Their cholinium salts exhibited significantly increased antibacterial potency, with the DCA\u2013choline salt performing over 40% better than DCA alone.<\/li>\n<\/ol>\n<p>Overall, the results reveal that while certain bile acid salts can enhance antibacterial activity, they do not improve antiviral efficacy against SARS-CoV-2, offering valuable insights for future therapeutic and formulation research.<\/p>\n<\/div><\/section><\/p><\/div><div  class='flex_column av-p8p34y-8ceaf983d8d88da9b35f0ed638e27432 av_one_fifth  avia-builder-el-16  el_after_av_three_fifth  el_before_av_one_fifth  flex_column_div  column-top-margin'     ><\/div><div  class='flex_column av-6l2nzb6-25e886e28bcf31716293eae0ff666237 av_one_fifth  avia-builder-el-17  el_after_av_one_fifth  el_before_av_three_fifth  first flex_column_div  column-top-margin'     ><\/div><div  class='flex_column av-mn815u-59a509b19d19b69b27d21766eceedcf7 av_three_fifth  avia-builder-el-18  el_after_av_one_fifth  el_before_av_one_fifth  flex_column_div  column-top-margin'     ><div id='av-masonry-1' class='av-masonry av-mj2gl45a-89ef16dcc0695d9d31e3b4772ff2f625 noHover av-fixed-size av-large-gap av-hover-overlay-active av-masonry-animation-active av-masonry-col-3 av-caption-always av-caption-style- av-masonry-gallery av-orientation-square ' data-post_id=\"61794\"><div class=\"av-masonry-container isotope av-js-disabled\"><div class='av-masonry-entry isotope-item 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https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1.png 1920w\" data-sizes=\"(max-width: 1030px) 100vw, 1030px\"  aria-label=\"image \u0e02\u0e48\u0e32\u0e27 SiCOREs\"  id='av-masonry-1-item-61795' data-av-masonry-item='61795' class='av-masonry-entry isotope-item post-61795 attachment type-attachment status-inherit hentry  av-masonry-item-with-image' title=\"\u0e02\u0e48\u0e32\u0e27 SiCOREs\" alt=\"\"    itemprop=\"thumbnailUrl\" ><div class='av-inner-masonry-sizer'><\/div><figure class='av-inner-masonry main_color'><div class=\"av-masonry-outerimage-container\"><div class='av-masonry-image-container' style=\"background-image: url(https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2025\/12\/\u0e02\u0e48\u0e32\u0e27-SiCOREs-1-845x684.png);\"  title=\"\u0e02\u0e48\u0e32\u0e27 SiCOREs\" ><\/div><\/div><\/figure><\/a><!--end av-masonry entry--><\/div><\/div><\/div><div  class='flex_column av-5wafs5e-e2204c005f8bb025ce1f52faa1022fe5 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><div class='av-magazine-group sort_all'><article class='av-magazine-entry av-magazine-entry-id-64812 av-magazine-format-standard av-magazine-type-post av-magazine-entry-1 av-magazine-entry-small '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"av-magazine-thumbnail\"><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-faculty-members-contribute-to-evtm-asia-2026-and-advance-international-collaboration-in-trauma-care\/' title='Link to: Siriraj Faculty Members Contribute to EVTM Asia 2026 and Advance International Collaboration in Trauma Care' class='av-magazine-thumbnail-link'><img decoding=\"async\" fetchpriority=\"high\" width=\"80\" height=\"80\" src=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/CON-SUR-80x80.jpg\" class=\"wp-image-64817 avia-img-lazy-loading-not-64817 attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/CON-SUR-80x80.jpg 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/CON-SUR-36x36.jpg 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/CON-SUR-180x180.jpg 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj Faculty Members Contribute to EVTM Asia 2026 and Advance International Collaboration in Trauma Care\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-10-20T13:15:51+07:00\" >October 20, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-faculty-members-contribute-to-evtm-asia-2026-and-advance-international-collaboration-in-trauma-care\/' title='Link to: Siriraj Faculty Members Contribute to EVTM Asia 2026 and Advance International Collaboration in Trauma Care'>Siriraj Faculty Members Contribute to EVTM Asia 2026 and Advance International Collaboration in Trauma Care<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><article class='av-magazine-entry av-magazine-entry-id-64795 av-magazine-format-standard av-magazine-type-post av-magazine-entry-2 av-magazine-entry-small '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"av-magazine-thumbnail\"><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-international-visiting-scholar-at-department-of-surgery-2\/' title='Link to: Siriraj International Visiting Scholar at Department of Surgery' class='av-magazine-thumbnail-link'><img decoding=\"async\" fetchpriority=\"high\" width=\"80\" height=\"80\" src=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/Prof.-Ross-Milner-3898-80x80.jpg\" class=\"wp-image-64799 avia-img-lazy-loading-not-64799 attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/Prof.-Ross-Milner-3898-80x80.jpg 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/Prof.-Ross-Milner-3898-36x36.jpg 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/Prof.-Ross-Milner-3898-180x180.jpg 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj International Visiting Scholar at Department of Surgery\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-10-20T10:59:19+07:00\" >October 20, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-international-visiting-scholar-at-department-of-surgery-2\/' title='Link to: Siriraj International Visiting Scholar at Department of Surgery'>Siriraj International Visiting Scholar at Department of Surgery<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><article class='av-magazine-entry av-magazine-entry-id-64707 av-magazine-format-standard av-magazine-type-post av-magazine-entry-3 av-magazine-entry-small '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"av-magazine-thumbnail\"><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-faculty-abroad-at-the-ecnp-2025-congress-in-germany\/' title='Link to: Siriraj Faculty Abroad at the ECNP 2025 Congress in Germany' class='av-magazine-thumbnail-link'><img decoding=\"async\" fetchpriority=\"high\" width=\"80\" height=\"80\" src=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/970B496A-BBAD-4FA6-9818-02594DAC262C-Somboon-Hataiyusuk-80x80.png\" class=\"wp-image-64710 avia-img-lazy-loading-not-64710 attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/970B496A-BBAD-4FA6-9818-02594DAC262C-Somboon-Hataiyusuk-80x80.png 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/970B496A-BBAD-4FA6-9818-02594DAC262C-Somboon-Hataiyusuk-36x36.png 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/970B496A-BBAD-4FA6-9818-02594DAC262C-Somboon-Hataiyusuk-180x180.png 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj Faculty Abroad at the ECNP 2025 Congress in Germany\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-10-13T09:52:10+07:00\" >October 13, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-faculty-abroad-at-the-ecnp-2025-congress-in-germany\/' title='Link to: Siriraj Faculty Abroad at the ECNP 2025 Congress in Germany'>Siriraj Faculty Abroad at the ECNP 2025 Congress in Germany<\/a><\/h3><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/article><article class='av-magazine-entry av-magazine-entry-id-64756 av-magazine-format-standard av-magazine-type-post av-magazine-entry-4 av-magazine-entry-small '  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class=\"av-magazine-thumbnail\"><a href='https:\/\/www2.si.mahidol.ac.th\/en\/news-events\/siriraj-faculty-abroad-at-the-1st-ashra-congress-in-japan-2\/' title='Link to: Siriraj Faculty Abroad at the 1st ASHRA Congress in Japan' class='av-magazine-thumbnail-link'><img decoding=\"async\" fetchpriority=\"high\" width=\"80\" height=\"80\" src=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/logo_ashra-80x80.png\" class=\"wp-image-64757 avia-img-lazy-loading-not-64757 attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/logo_ashra-80x80.png 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/logo_ashra-36x36.png 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/logo_ashra-180x180.png 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj Faculty Abroad at the 1st ASHRA Congress in Japan\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-10-11T11:49:35+07:00\" >October 11, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a 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src=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/main-80x80.png\" class=\"wp-image-64753 avia-img-lazy-loading-not-64753 attachment-thumbnail size-thumbnail wp-post-image\" alt=\"\" srcset=\"https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/main-80x80.png 80w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/main-36x36.png 36w, https:\/\/www2.si.mahidol.ac.th\/en\/wp-content\/uploads\/2026\/10\/main-180x180.png 180w\" sizes=\"(max-width: 80px) 100vw, 80px\" \/><\/a><\/div><div class=\"av-magazine-content-wrap\"><header class=\"entry-content-header\" aria-label=\"Post: Siriraj Faculty Abroad at the 1st ASHRA Congress in Japan\"><time class='av-magazine-time updated'  itemprop=\"datePublished\" datetime=\"2026-10-11T11:09:40+07:00\" >October 11, 2026<\/time><h3 class='av-magazine-title entry-title '  itemprop=\"headline\" ><a 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