Author Archives: Poorintra Sakuna

Pattipong Wisanpitayakorn, Adchata Konsue, Thanutchaporn Sartyoungkul, Ammarin In-On, Yongyut Sirivatanauksorn, David R Gang, Prasat Kittakoop, Sakda Khoomrung Abstract Conventional mass spectrometry imaging (MSI), even when combined with low-resolution ion mobility, lacks the resolving power to distinguish stereoisomers. To address this limitation, we developed a high-resolution desorption electrospray ionization cyclic ion mobility mass spectrometry (DESI-cIM-MS) method […]

Weerawan Manokasemsan, Narumol Jariyasopit, Kwanjeera Wanichthanarak, Patcha Poungsombat, Alongkorn Kurilung, Suphitcha Limjiasahapong, Kajol Thapa, Yongyut Sirivatanauksorn, Sukit Raksasuk, Thatsaphan Srithongkul, Chagriya Kitiyakara, Sakda Khoomrung Abstract We developed a robust LC–MS/MS method for the simultaneous quantification of 16 uremic toxins (UTs) and 14 bile acids (BAs) in plasma and fecal samples within a single method. The […]

Lucksamon Thamlikitkul, Kwanjeera Wanichthanarak, Siriphan Manocheewa, Suphitcha Limjiasahapong, Natthaporn Phonsatta, Sujichon Thangvichien, Atikorn Panya, Yongyut Sirivatanauksorn, Naravat Poungvarin, Sakda Khoomrung Abstract Lung cancer remains the leading cause of cancer-related mortality worldwide, underscoring the urgent need for non-invasive approaches to improve diagnosis, patient stratification, and therapeutic monitoring. Metabolic reprogramming driven by oncogenic alterations-particularly Epidermal Growth Factor […]

Jantarika Kumar Arora, Louisa K James, Varodom Charoensawan Abstract Droplet-based single-cell RNA sequencing (scRNA-seq) frequently encounters significant challenges from contamination of cell-free mRNAs, known as “ambient mRNAs”, which can substantially distort single-cell transcriptome data interpretation to a large extent. In this study, we investigate the impact of ambient mRNA contamination on differential gene expression and […]

Phakwan Laohathai, Rathaporn Sumboonnanonda, Puthita Saengpanit, Chodchanok Vijarnsorn, Chatchawan Srisawat , Kwanjai Chotipanang, Sarawut Junnu , Supawan Kunnangja, Hathaichanok Rukprayoon, Phakkanan Phuangphan, Sompong Liammongkolkul , Arthima Phaokong, Narumon Densupsoontorn Abstract Background: Thiamin deficiency (TD) manifesting clinically as wet beriberi can significantly impair a patient’s cardiac function. Children with heart disease who are receiving diuretic treatment […]

Sakunrat Ubonprasert, Wachiraporn Wachiradusit, Wichai Pornthanakasem, Warangkhana Songsungthong, Aritsara Jaruwat, Sasina Premjaichon, Tanaporn Uengwetwanit, Rinrada Suntivich, Konrawee Thananon, Kanyarat Suksomjaisaman, Jeerus Sucharitakul, Chutathip Puyprom, Tamonwan Lotangchanintra, Kanokwan Salamteh, Kittikhun Wangkanont, Channarong Rodkhum, Wonnop Visessanguan , Pimchai Chaiyen, Penchit Chitnumsub, Ubolsree Leartsakulpanich Abstract Bacteriophage endolysins are attractive alternatives to antibiotics owing to their rapid action, host […]

Kongtana Trakarnsanga , Nutchavadee Vorasan, Nutnicha Tantarungsee , Methichit Wattanapanitch, Chinnavuth Vatanashevanopakorn, Bhoom Suktitipat , Chanatip Metheetrairut Abstract Objective: Induced pluripotent stem cells (iPSCs) are generated from a vast number of adult cell types. While they all acquired embryonic stem cell (ESC)-like properties during reprogramming, differences in certain characteristics, including differentiation potential, remained. These differences […]

Alongkorn Kurilung, Suphitcha Limjiasahapong, Kwanjeera Wanichthanarak, Weerawan Manokasemsan, Khwanta Kaewnarin, Kassaporn Duangkumpha, Siriphan Manocheewa, Rossarin Tansawat, Roongruedee Chaiteerakij, Intawat Nookaew, Yongyut Sirivatanauksorn, Sakda Khoomrung Abstract This study presents the development and validation of a liquid chromatography-quadrupole-time-of-flight mass spectrometry method with data-independent acquisition (LC-QTOF-MSE) for targeted quantification, post-targeted screening, and untargeted metabolite profiling. Using MS1-based precursor […]

Sirinapa Sripinitchai , Benchaporn Lertanantawong, Thanyarat Chaibun, Chamras Promptmas, Charin Thawornkuno, Uraiwan Kositanont, Chatchawan Srisawat Abstract The polyhistidine (His) tag is one of the most widely used tags for protein expression, detection, and purification. Aptamers targeting the His tag have been developed for various applications, including western blotting, flow cytometry, immunohistochemistry, and immunoprecipitation, due to […]

Jerald Tan, Chutipong Chiamkunakorn, Kanpapat Boonchuay, Yiying Shi, Bart P Braeckman, Wichit Suthammarak Abstract Metformin has been demonstrated to extend lifespan in various model organisms, and its molecular effects are observed in the cytoplasm and multiple organelles, including mitochondria. However, its association with the unfolded protein response (UPR) and its impact on stress resistance and […]