Author Archives: Poorintra Sakuna

Genomic Assessment, Metabolic Profile Mapping, and Anti-Helicobacter pylori Activity of Lactococcus lactis SK2-659 from Thai Fermented Green Mustard (Pak-kad-dong)

Engkarat Kingkaew, Weerapong Woraprayote, Jaruwan Sitdhipol, Ratha-Korn Vilaichone, Wonnop Visessanguan , Somboon Tanasupawat Abstract Probiotics play crucial roles in promoting gut health, enhancing immunity, and combating pathogenic microorganisms, with increasing interest in their applications in the food and therapeutic industries. Lactococcus lactis, a well-known lactic acid bacterium, has emerged as a promising candidate owing to […]

Performance of electrochemical aptasensor as antigen test in clinical samples for early diagnosis of leptospirosis

Uraiwan Kositanont, Benchaporn Lertanantawong, Kanitha Patarakul, Sirinapa Sripinitchai , Charin Thawornkuno, Thanyarat Chaibun, Chahya Kreangkaiwal, Wassa Waiwinya, Chamras Promptmas, Chatchawan Srisawat Abstract Early diagnosis of leptospirosis is critical for timely treatment and effective disease management. This study evaluated the diagnostic performance of a novel electrochemical aptasensor targeting the electron transfer flavoprotein subunit beta (EtfB) of […]

Cytokine and chemokine kinetics in natural human dengue infection as predictors of disease outcome

Natnicha Jiravejchakul, Wilawan Chan-In, Walairat Thuncharoen; DENFREE Thailand; Waradon Sungnak, Varodom Charoensawan , Vimvara Vacharathit, Ponpan Matangkasombut Abstract Dengue is an important tropical disease with considerable global impact. Despite this, there remains an urgent need for reliable biomarkers to predict disease severity, as well as effective antiviral drugs and targeted treatments. In this study, we […]

Perturbations in L-serine metabolism regulate protein quality control through the sensor of the retrograde response pathway RTG2 in Saccharomyces cerevisiae

Kanika Saxena, Rebecca Andersson, Per O Widlund, Sakda Khoomrung, Sarah Hanzén, Jens Nielsen, Navinder Kumar, Mikael Molin, Thomas Nyström Abstract Cellular protein homeostasis relies on a complex network of protein synthesis, folding, sub-cellular localization, and degradation to sustain a functional proteome. Since most of these processes are energy-driven, proteostasis is inescapably afflicted by cellular metabolism. […]

รับสมัครแพทย์ใช้ทุนสาขาชีวเคมี ปีการศึกษา 2568

รับสมัครแพทย์ใช้ทุนสาขาชีวเคมี ปีการศึกษา 2568 3 ตำแหน่ง มีโอกาสช่วยงานวิจัยอาจารย์ทั้ง PRECLINIC และ CLINIC เป็นโอกาสเรียนต่อในอนาคต มีโอกาสช่วยสอนและวางรูปแบบการสอนให้นักศึกษาแพทย์ชั้น PRECLINIC บรรยากาศการทำงานเป็นกันเอง มี WORK LIFE BALANCE

Pathogenic Characteristics of Shrimp Early Mortality Syndrome (EMS)-Causing Vibrio parahaemolyticus: A Comparative Transcriptomic Study Suggests the Relationship Between Metabolic Fitness and Virulence Gene Expression

Nalumon Thadtapong, Varodom Charoensawan, Vanvimon Saksmerprome, Soraya Chaturongakul Abstract Vibrio parahaemolyticus (VP) is a major bacterial species that causes early mortality syndrome (EMS) in shrimps. EMS can be classified into two groups based on histological signs of hepatopancreatic tissues, i.e., acute hepatopancreatic necrosis disease (AHPND) and non-AHPND. To investigate how toxin-producing AHPND and toxin-lacking non-AHPND […]

A study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand

Korawit Opassathian, Nawarat Boonmee, Saowanee Swangkaew, Piroon Jenjaroenpun, Thidathip Wongsurawat, Worarat Kruasuwan, Popchai Ngamskulrungroj, Chalermchai Mitrpant Abstract Candida auris, one of the emerging multidrug-resistant Candida species, was first discovered in 2009 from the ear canal of a patient in Tokyo, Japan. Since then, several studies exhibit the possible threats of C. auris due to its […]

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber’s hereditary optic neuropathy

Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol Abstract Leber’s hereditary optic neuropathy (LHON) is a maternally inherited disorder caused by mitochondrial DNA mutations in complex I of the respiratory chain, leading to impaired ATP production, mitochondrial fragmentation, and oxidative stress that contribute to vision loss. This study investigated the potential repurposing of metformin, a […]

Unveiling distinct storage composition and starch properties in developing indica rice grains via transcriptional profiling and enzymatic activity analysis

Wichian Sangwongchai, Kwanjeera Wanichthanarak, Ammarin In-on, Supidcha Natee, Chamaiporn Champasri, Nutcha Sa-ingthong, Diane M. Beckles, Sakda Khoomrung, Maysaya Thitisaksakul Abstract The starch and protein in rice grains determine their nutritional value, eating and cooking quality (ECQ), and potential applications as a biopolymer. Building on previously identified functional differences between two Thai indica cultivars, waxy RD6 […]