Category Archives: Research Innovation

Combining Histopathologic and Gene-Expression Profiling for Risk Stratification of Nodal Metastasis in Colorectal Cancer

Watsaphon Tangkullayanone, Nutchavadee Vorasan, Amphun Chaiboonchoe, Atthaphorn Trakarnsanga, Pariyada Tanjak, Thanawat Suwatthanarak, Woramin Riansuwan, Kullanist Thanormjit, Onchira Acharayothin, Asada Methasate, Yusuke Kinugasa, Bhoom Suktitipat, Vitoon Chinswangwatanakul Abstract Objective: To identify gene-expression features associated with lymph node metastasis (LNM) in colorectal cancer (CRC) and to develop a transcriptomic-clinical predictive model for preoperative nodal assessment. Materials and […]

Yield and Properties of Collagen from Nile Tilapia (Oreochromis niloticus) Scales: Effects of Ultrasonic Pretreatment on Pepsin-Aided Extraction

Phanat Kittiphattanabawon, Hideki Kishimura, Soottawat Benjakul, Wonnop Visessanguan Abstract The yield and characteristics of collagen from Nile tilapia scale pretreated with ultrasound at 40 kHz for 2 h before pepsin-aided extraction for 12-72 h (US collagen) were investigated compared to collagen from the scales without ultrasonic pretreatment (non-US collagen). Both collagens’ yields increased with prolonged […]

Identifying GFAP-expressing cell susceptibility to SARS-CoV-2 infection using human iPSC-derived neural cells

Nithi Asavapanumas, Phaewa Chaiwijit, Ampa Suksatu, Saroj Kasemsinsup, Nongluk Saikachain, Juthamard Chantaraamporn, Suchanan Chieowisaman, Sarintip Nguantad, Damita Jevapatarakul, Narita Thungsatianpun, Tanapat Pornsukjantra, Tanida Chokpanuwat, Suwimon Manopwisedjaroen, Kanit Bhukhai, Patompon Wongtrakoongate, Suradej Hongeng, Ponpan Matangkasombut, Varodom Charoensawan, Arunee Thitithanyanont Abstract Neurological manifestations are common in COVID-19. However, a key limitation to understanding the mechanisms and developing […]

Dual Targeting of FAP-Directed Nanoparticles and FRα-Specific CAR-T Cells Induces Additive Anti-Tumor Effects in Triple-Negative Breast Cancer

Tanva Thongkleang, Suyanee Thongchot, Kamonlatth Rodponthukwaji, Piriya Luangwattananun, Kwanruthai Tadpetch, Pa Thai Yenchitsomanus, Peti Thuwajit, Primana Punnakitikashem, Chanitra Thuwajit Abstract Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited treatment options. It lacks hormone receptors and human epidermal growth factor receptor 2. The immunosuppressive tumor microenvironment (TME), particularly cancer-associated fibroblasts (CAFs), significantly hinders chimeric […]

Impact of thiamin supplementation on thiamin pyrophosphate effect and cardiac function in pediatric heart disease patients on diuretics: a randomized controlled trial

Rathaporn Sumboonnanonda, Chodchanok Vijarnsorn, Puthita Saengpanit, Chatchawan Srisawat, Kwanjai Chotipanang, Sarawut Junnu, Supawan Kunnangja, Hathaichanok Rukprayoon, Phakkanan Phuangphan, Bordeesuda Suiwongsa, Sompong Liammongkolkul, Phakwan Laohathai, Narumon Densupsoontorn Abstract Background and Aims :Thiamin is a water-soluble vitamin essential for energy metabolism. Patients on long-term diuretics, particularly those with heart disease, are at risk of thiamin deficiency (TD) […]

Comparative evaluation of stability, efficacy, and sterility in five repackaged intravitreal anti-vascular endothelial growth factor medications

Panintorn Thunwiriya, Tanaporn Phetruen, Phaewa Chaiwijit, Chaiyawat Tonawannakorn, Kanokwan Dekham, Nalumon Thadtapong, Soraya Chaturongakul, Varodom Charoensawan , Sittinan Chanarat, Danaya Pakotiprapha, Prut Hanutsaha Abstract Intravitreal injection anti-vascular endothelial growth factor (VEGF) drugs offer significant benefits for individuals with retinal diseases, yet high cost and limited availability impede widespread use. Compounding and repackaging present a potential […]

Appendicolith detection in dual-energy CT of adult acute appendicitis: comparing portovenous phase and virtual noncontrast with true noncontrast images

Rathachai Kaewlai, Jitti Chatpuwaphat, Sasima Tongsai, Piyachai Siriphiphatcharoen, Papasorn Wattanakul, Patcharaporn Thaisuriyo, Dhanawin Wongsaengchan, Napakadol Noppakunsomboon, Shanigarn Thiravit. Abstract Objectives: Appendicoliths are associated with failed nonoperative management in acute appendicitis and are used to exclude patients from this treatment. This study evaluated whether portovenous phase (PVP) and virtual noncontrast (VNC) images from rapid-kVP-switching dual-energy CT […]

Clostridioides difficile infection increases in-hospital mortality, length of stay, and hospital cost but not 30-day mortality in cirrhotic patients

Aunchalee Jaroenlapnopparat,Vitchapong Prasitsumrit, Ben Ponvilawan, Palapun Waitayangkoon , Nipith Charoenngam Abstract Background and aim: Clostridioides difficile infection (CDI) is a leading cause of nosocomial infection and is associated with both higher morbidity and mortality. Cirrhotic patients are more susceptible to CDI because of impaired gut immune response, use of proton pump inhibitor, and frequent hospitalization. […]

Mitochondrial DNA sequence diversity in Kedayan population

HashomMohd Hakim, Japareng Lalung, AungWin Tun, Patcharee Lertrit, Supannee Kaewsutthi, Citra Manela, Fika Tri Anggraini, Abd Rashid Nur Haslindawaty, Che Ghazali Norul Hajar, Hisham Atan Edinur Abstract The Kedayan is an indigenous population in Borneo who speak the Austronesian language, and majority of them live in Sabah and Sarawak on the Malaysian side of the […]

Saccharification of carrot pomace and use as nutrient source for the production of ꞵ-cryptoxanthin by Pantoea anthophila FL1_IS5

Sopida Korkerd, Savitri Vatanyoopaisarn, Wonnop Visessanguan, Benjawan Thumthanarak, Caroline L. Perez, Vilai Rungsardthong, Solange I. Mussatto Abstract Carrot pomace represents a rich source of nutritional components such as polysaccharides, dietary fiber, phenolic compounds, and ꞵ-carotene, which can be utilized as alternative sources to produce value-added products. In this research, carrot pomace was hydrolyzed to release […]