Assoc. Prof. Ruchaneekorn W. Kalpravidh, PhD (Faculty Advisor)

  • Ph.D. (Cell Biology), Colorado State University, U.S.A..

1017 Srisavarindira Bldg. 10th Fl. Department of Biochemistry. Faculty of Medicine Siriraj Hospital, Bangkoknoi, Bangkok 10700

Laboratory : 920 Srisavarindira Bldg. 9rd Fl.

Phone : (02) 419-7584

E-Mail : ruchaneekorn.kal@mahidol.ac.th

Research Profile

My area of research interest involves the biochemistry of oxidative stress and nutritional antioxidant interventions in the treatment of human disease such as thalassemia.

Current research interests include :

  • Elucidation the role of natural antioxidant, curcumin and antioxidant cocktails in reducing oxidative stress and improving quality of life of thalassemic patients.
  • Proteomic analysis of plasma protein in thalassemic patients treated with curcumin.
1. Wahawisan R, Gorell TA. Steroidal control of rat uterine 17 beta-hydroxysteroid dehydrogenase activity. Steroids 1980;36(1):115-129.
2. Patinawin S, Wahawisan R, Gorell TA. Histochemical localization of 17 beta-hydroxysteroid dehydrogenase activity in rat uterus. J Steroid Biochem 1980;13(11):1277-81.
3. Lessey BA, Wahawisan R, Gorell TA. Hormonal regulation of cytoplasmic estrogen and progesterone receptors in the beagle uterus and oviduct. Mol Cell Endocrinol 1981;21(2):171-80.
4. Wahawisan R, Gaginella TS, Wallace LJ. Jejunal-ileal differences in dopaminergic but not alpha-adrenergic antisecretory effects. Am J Physiol 1985;248(3 Pt 1):G332-6.
5. Tien XY, Wahawisan R, Wallace LJ, Gaginella TS. Intestinal epithelial cells and musculature contain different muscarinic binding sites. Life Sci 1985;36(20):1949-55.
6. Wahawisan R, Wallace LJ, Gaginella TS. Muscarinic receptors on rat ileal villus and crypt cells. J Pharm Pharmacol 1986;38(2):150-3.
7. Wahawisan, R., Richards, N. W., Gaginella, T. S., & Wallace, L. J. (1986). Effects of phenothiazines on phosphate incorporation and chloride uptake in isolated intestinal epithelial cells. General pharmacology, 17(3), 275–280. https://doi.org/10.1016/0306-3623(86)90041-8
8. Kalpravidh, R. W., & Bunrueang, N. (1998). 17β-Hydroxysteroid dehydrogenase activity in uterine cervix of normal subjects and carcinoma patients. IMSEAR / SEA-138239.
9. Chuntapet, P., Kalpravidh, R. W., Neungton, N., Mungkornkarn, C., & Skulchan, V. (1989). The determination of beta-aminoisobutyric acid in urine of normal and cancer patients.Clinica Chimica Acta, 184(2), 137–143. https://doi.org/10.1016/0009-8981(89)90308-4
10. Kalpravidh, R. W., Komolvanich, S., Wilairat, P., & Fucharoen, S. (1995). Globin chain turnover in reticulocytes from patients with beta (0) -thalassaemia/Hb E disease. European journal of haematology, 55(5), 322–326. https://doi.org/10.1111/j.1600-0609.1995.tb00704.x
11. Wannasuphaphol, B., Kalpravidh, R. , Pattanapanyasat, K., Ioannau, P., Kuypers, F. A., Fucharoen, S., & Winichagoon, P. (2005). Rescued mice with Hb E transgene-developed red cell changes similar to human beta-thalassemia/HbE disease. Annals of the New York Academy of Sciences, 1054, 407–416. https://doi.org/10.1196/annals.1345.049
12. Kalpravidh, R. W., Wichit, A., Siritanaratkul, N., & Fucharoen, S. (2005). Effect of coenzyme Q10 as an antioxidant in beta-thalassemia/Hb E patients. BioFactors (Oxford, England), 25(1-4), 225–234. https://doi.org/10.1002/biof.5520250128
13. Jintaridth, P., Srisomsap, C., Vichittumaros, K., Kalpravidh, R. W., Winichagoon, P., Fucharoen, S., Jisnuson Svasti, M. R., & Kasinrerk, W. (2006). Chicken egg yolk antibodies specific for the gamma chain of human hemoglobin for diagnosis of thalassemia.International journal of hematology, 83(5), 408–414. https://doi.org/10.1532/IJH97.A20515
14. Matayatsuk, C., Poljak, A., Bustamante, S., Smythe, G. A., Kalpravidh, R. W., Sirankapracha, P., Fucharoen, S., & Wilairat, P. (2007). Quantitative determination of ortho- and meta-tyrosine as biomarkers of protein oxidative damage in beta-thalassemia. Redox report : communications in free radical research, 12(5), 219–228. https://doi.org/10.1179/135100007X200272
15. Matayatsuk, C., Lee, C. Y.,Kalpravidh, R. W., Sirankapracha, P., Wilairat, P., Fucharoen, S., & Halliwell, B. (2007). Elevated F2-isoprostanes in thalassemic patients. Free radical biology & medicine, 43(12), 1649–1655. https://doi.org/10.1016/j.freeradbiomed.2007.08.026
16. Meerang, M., Nair, J., Sirankapracha, P., Thephinlap, C., Srichairatanakool, S., Arab, K.,Kalpravidh, R. W., Vadolas, J., Fucharoen, S., & Bartsch, H. (2009). Accumulation of lipid peroxidation-derived DNA lesions in iron-overloaded thalassemic mouse livers: comparison with levels in the lymphocytes of thalassemia patients. International journal of cancer, 125(4), 759–766. https://doi.org/10.1002/ijc.24412
17. Bumrungpert, A., Kalpravidh, R. W., Suksamrarn, S., Chaivisuthangkura, A., Chitchumroonchokchai, C., & Failla, M. L. (2009). Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells. Molecular nutrition & food research, 53 Suppl 1, S54–S61. https://doi.org/10.1002/mnfr.200800260
18. Bumrungpert, A., Kalpravidh, R. W., Chitchumroonchokchai, C., Chuang, C. C., West, T., Kennedy, A., & McIntosh, M. (2009). Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. The Journal of nutrition, 139(6), 1185–1191. https://doi.org/10.3945/jn.109.106617
19. Kalpravidh, R. W., Siritanaratkul, N., Insain, P., Charoensakdi, R., Panichkul, N., Hatairaktham, S., Srichairatanakool, S., Phisalaphong, C., Rachmilewitz, E., & Fucharoen, S. (2010). Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids.Clinical biochemistry, 43(4-5), 424–429. https://doi.org/10.1016/j.clinbiochem.2009.10.057
20. Kalpravidh, R. W., & Hatairaktham, S. (2012). Role of antioxidant and iron-chelating therapies in thalassemia patients. In A. M. Reyes & C. D. Contreras (Eds.), Handbook on oxidative stress: New research (pp. 329–346).Nova Science Publishers.
21. Kalpravidh, R. W., Tangjaidee, T., Hatairaktham, S., Charoensakdi, R., Panichkul, N., Siritanaratkul, N., & Fucharoen, S. (2013). Glutathione redox system in β -thalassemia/Hb E patients. TheScientificWorldJournal, 2013, 543973. https://doi.org/10.1155/2013/543973
22. Hatairaktham, S., Srisawat, C., Siritanaratkul, N., Chiangjong, W., Fucharoen, S., Thongboonkerd, V., & Kalpravidh, R. W.(2013). Differential plasma proteome profiles of mild versus severe β-thalassemia/Hb E. Annals of hematology, 92(3), 365–377. https://doi.org/10.1007/s00277-012-1629-5
23. Weeraphan, C., Srisomsap, C., Chokchaichamnankit, D., Subhasitanont, P., Hatairaktham, S., Charoensakdi, R., Panichkul, N., Siritanaratkul, N., Fucharoen, S., Svasti, J., & Kalpravidh, R. W. (2013). Role of curcuminoids in ameliorating oxidative modification in β-thalassemia/Hb E plasma proteome. The Journal of nutritional biochemistry, 24(3), 578–585. https://doi.org/10.1016/j.jnutbio.2012.02.008
24. Kalpravidh, R. W., & Hatairaktham, S. (2014). Antioxidant therapies for thalassemia. In M. Greene (Ed.), Thalassemia: Causes, treatment options and long-term health outcomes (pp. 155–174). Nova Science Publishers.
25. Yanpanitch, O. U., Hatairaktham, S., Charoensakdi, R., Panichkul, N., Fucharoen, S., Srichairatanakool, S., Siritanaratkul, N., & Kalpravidh, R. W.(2015). Treatment of β-Thalassemia/Hemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State. Oxidative medicine and cellular longevity, 2015, 537954. https://doi.org/10.1155/2015/537954
26. Bumrungpert, A., Pavadhgul, P., & Kalpravidh, R. W.(2016). Camellia Oil-Enriched Diet Attenuates Oxidative Stress and Inflammatory Markers in Hypercholesterolemic Subjects. Journal of medicinal food, 19(9), 895–898. https://doi.org/10.1089/jmf.2016.3659
27. Wongchanchailert, M., Sullivan, P. B., Kalpravidh, R. W.,Chotsampancharoen, T., Apiromrak, P., Khotchawan, S., & Duangchu, S. (2016). No effect of vitamin E on oxidative parameters or quality of life in children with transfusion-dependent thalassemia. Pediatric Hematology Oncology Journal, 1(4), 75-79. https://doi.org/10.1016/j.phoj.2017.03.004
28. Santiprabhob, J., Limprayoon, K., Aanpreung, P., Charoensakdi, R.,Kalpravidh, R. W., Phonrat, B., & Tungtrongchitr, R. (2018). Impact of a group-based treatment program on adipocytokines, oxidative status, inflammatory cytokines and arterial stiffness in obese children and adolescents. Journal of pediatric endocrinology & metabolism : JPEM, 31(7), 733–742. https://doi.org/10.1515/jpem-2018-0012
29. Panachan, J., Chokchaichamnankit, D., Weeraphan, C., Srisomsap, C., Masaratana, P., Hatairaktham, S., Panichkul, N., Svasti, J., & Kalpravidh, R. W.(2019). Differentially expressed plasma proteins of β-thalassemia/hemoglobin E patients in response to curcuminoids/vitamin E antioxidant cocktails. Hematology (Amsterdam, Netherlands), 24(1), 300–307. https://doi.org/10.1080/16078454.2019.1568354
30. Hatairaktham, S., Masaratana, P., Hantaweepant, C., Srisawat, C., Sirivatanauksorn, V., Siritanaratkul, N., Panichkul, N., & Kalpravidh, R. W.(2021). Curcuminoids supplementation ameliorates iron overload, oxidative stress, hypercoagulability, and inflammation in non-transfusion-dependent β-thalassemia/Hb E patients. Annals of hematology, 100(4), 891–901. https://doi.org/10.1007/s00277-020-04379-7

1.

Veerataveeporn N, Srisomsap C,Chokchaichamnankit, Srisawat C, Svasti J, Kalpravidh RW. Proteomic profile of coagulation proteins in β-thalassemia/Hb E patients treated with curcuminoids antioxidant cocktail. The 26th Annual Meeting of The Thai Society for Biotechnology and International Conference, Mae Fah Luang University Chiang Rai , Thailand 26-29 November 2014

2.

Veerataveeporn N, Srisomsap C, Thongboonkerd V, Srisawat C, Svasti J, Kalpravidh RW. Proteomic analysis of plasma proteins in responded and non-responded β-thalassemia/Hb E patients treated with antioxidant cocktail.International Conference of the Korean Society for Molecular and cellular Biology 2013, October 9-11,2013,COEX,Korea

3.

Veerataveeporn N, Srisomsap C, Thongboonkerd V, Srisawat C, Svasti J, Kalpravidh RW. Proteomic analysis of plasma proteins in responded and non-responded β-thalassemia/Hb E patients treated with antioxidant cocktail.The 8th International Symposium of The Protein Society of Thailand, Convention Center, Chulabhon Research Institute, Bangkok Thailand 5-7 August 2013

4.

Hatairaktham S, Srisawat C, Siritanaratkul N, Chiangjong W, Fucharoen S, Thongboonkerd V, Kalpravidh RW. Plasma proteome profiles of mild versus severe β-thalassemia/Hb E. The 2nd Thailand National Research University Summit, Queen Sirikit Convention Center, Bangkok Thailand 7-8 May 2013

5.

Phoonlapdacha P, Chongviriyaphan N, Pakakasama S, Sangcakul A, Kalpravidh RW, Suthutvoravut U. Oxidative stress in pediatric patients with acute lymphoblastic leukemia at the time of diagnosis and during chemotherapy. Joint Conference in Medical Sciences 2011: Chula-Rama-Siriraj (JCMS2011), June 15-17, 2011 at IMPACT Exhibition and Convention Center, Thailand: 84.

6.

Phoonlapdacha P, Pakakasama S, Suthutvoravut U, Kalpravidh RW, Chongviriyaphan N. Antioxidant status, lipid peroxidation, and DNA damage in pediatric patients with acute lymphoblastic leukemia. 19th International Congress of Nutrition (ICN 2009), October 4-9, 2009 at BITEC, Bangkok, Thailand.

7.

Kalpravidh RW, Weeraphan C, Srisomsap C, Siritanaratkul N, Svasti J. Proteomic analysis of plasma protein in b-thalassemia/HbE patients treated with curcumin. Experimental Biology 2009, April 18-22, 2009 at New Orleans, USA.

8.

Pongutta S, Kalpravidh RW, Charconkiatkul S, Chitchumroonchohchai C, Angkhasirisap W, Butadej D. Effect of carotenoid rich-food kang lieng on NAD(P)H: quinone reductase (QR) activity in wistar rats. FASEB Journal 2007;21:849.5.