Office:
Department of Immunology, Faculty of Medicine Siriraj Hospital,
Mahidol University, Bangkok Noi, Bangkok 10700 Thailand
Phage technology for health and agriculture
Prof. Dr. Sunee Korbsrisate
Ph.D. (Biochemistry), B.Sc. (Med Tech.)
Our interests are focused on the molecular biology of bacteriophages and their applications ranging from bacteriophage-based rapid diagnosis of infectious diseases, and exploiting bacteriophages and phage-derived products as an alternative to treating antibiotic resistant bacterial infections.
Highlight of Our Research Accomplishments
- Phage tail-fiber based latex agglutination test for rapid screening of Burkholderia pseudomallei (Petty patent)
- Lateral flow Immunoassay for rapid detection of Salmonella contamination in foods (Petty patent)
- Our research group received funding supports from both of the national and international funding agencies such as Welcome Trust (UK), Newton Fund (UK), and NSTDA (Thailand).
International Network
We are collaborating in phage studies with the pioneers of bacteriophage research such as Dr.Elizabeth Kutter, Evergreen State College, Olympia, USA; Prof.Martha RJ. Clokie, Leicester University, UK, Dr.Matthew Dunne, ETH, Switzerland.
In addition, we also have international collaborations with leading groups on Burkholderia pseudomallei research e.g. Prof.Mark P. Stevens, and Prof.Brendan Wren from UK.
Future Direction
Our research group has identified large sets of phages that effectively target Salmonella, Burkholderia, and are currently developing them as diagnostics and therapeutics agents.
In recent years, we have become increasingly interested in the genetics of phages that infect human pathogens. These genomes may provide the key to treatment of diseases caused by multi-drug-resistant bacteria e.g. Acinetobacter baumannii or treatment of biofilm formation generated from pathogenic bacteria.
Research Interest
Research Interest
- Development of bacteriophage-derived products as an alternative for treating antibiotic resistant bacterial infections e.g. Acinetobacter baumannii (Phage Therapy).
- Bacteriophages for biocontrol of Salmonella contamination in poultry.
- Rapid bacteriophage-based detection including direct detection of B.pseudomallei from clinical samples, rapid detection of Salmonella contamination in foods and clinical samples.
- Molecular mechanisms of bacteriophage on B.pseudomallei pathogenicity.
- Viromes and phageomes of clinical samples.
Our Research Strategy
- Bacteriophage-encapsulation
- Bacteriophages as bio-probes
- Reporter Phage
- Phage enzymes
- Lateral flow immunoassay
- NGS and analysis
Publications
People
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