Category Archives: Research Innovation

Investigating tumour heterogeneity in a melanoma arising in congenital melanocytic nevus using in situ spatial gene expression analysis

Jutapak Jenkitkonchai, Kittiporn Punuch , Teerapat Paringkarn, Teerapat Wannawittayapa, Manop Pithukpakorn, Panitta Sitthinamsuwan, Manasmon Chairatchaneeboon, Varodom Charoensawan Abstract Melanoma is one of the most aggressive skin cancers with high mortality rates.1 It frequently exhibits high heterogeneity, with diverse genetic and phenotypic characteristics, which often complicate accurate diagnosis, classification and treatment planning.2 A previous study showed […]

Antiviral and virucidal activities against SARS-CoV-2 and antibacterial properties of bile acids and their salts with naturally occurring organic cations of l-carnitine, creatinine, and choline

Chavalit Varongkriengkrai, Nopporn Chutiwitoonchai, Nontaphat Leerach, Sanya Sureram, Tam Pooprasert, Thammarat Aree, Sakda Khoomrung, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Abstract Bile acids have many roles in biological systems, and they have received great attention recently. Bile from a cow, known as gall, together with garlic, wine, and leeks, is used in the traditional medicine […]

Higher Plasma Kynurenine to Tryptophan Correlates with an Increased Incidence of Mild Cognitive Impairment in Treated Metabolic Syndrome Patients

Narumol Jariyasopit, Tiwat Phochmak, Siriphan Manocheewa, Kwanjeera Wanichthanarak, Suphitcha Limjiasahapong, Nichapa Kleebkomut, Yongyut Sirivatanauksorn, Vorapan Sirivatanauksorn, Arintaya Phrommintikul, Nipon Chattipakorn, Siriporn Chattipakorn, Sakda Khoomrung Abstract An increase in cognitive impairment was observed in metabolic syndrome (MetS) patients. Although alterations in metabolomic profiles have been identified as potential plasma/serum biomarkers of mild cognitive impairment (MCI) and […]

Whole exome sequencing and rare variant association study to identify genetic modifiers, KLF1 mutations, and a novel double mutation in Thai patients with hemoglobin E/beta-thalassemia

Chattree Hantaweepant, Bhoom Suktitipat, Manop Pithukpakorn, Yingyong Chinthammitr, Chanin Limwongse, Nawaporn Tansiri, Surasak Sawatnatee, Chayamon Takpradit, Wannaphorn Rotchanapanya, Saranya Pongudom, Kanyaporn Charoenprasert, Kittiphong Paiboonsukwong, Wichuda Thamprasert, Narumol Nolwachai, Wanlapa Rattanasawat, Busakorn Sae-Aeng, Nisachon Khorwanichakij, Putchong Saetow, Supawee Saengboon, Krittichat Kamjornpreecha, Wikanda Pholmoo, Boonyanuch Dujjawan, Noppadol Siritanaratkul Abstract Objectives: Clinical manifestations of patients with Hemoglobin E/beta-thalassemia […]

Prolonged Egg Supplement Advances Growing Child’s Growth and Gut Microbiota

Sophida Suta, Apinya Surawit, Pichanun Mongkolsucharitkul, Bonggochpass Pinsawas, Thamonwan Manosan, Suphawan Ophakas, Tanyaporn Pongkunakorn, Sureeporn Pumeiam, Kitti Sranacharoenpong, Sawannee Sutheeworapong, Patcha Poungsombat, Sakda Khoomrung, Pravit Akarasereenont, Iyarit Thaipisuttikul, Bhoom Suktitipat, Korapat Mayurasakorn Abstract Protein-energy malnutrition still impacts children’s growth and development. We investigated the prolonged effects of egg supplementation on growth and microbiota in primary […]

Induction of fetal hemoglobin: Lentiviral shRNA knockdown of HBS1L in β0-thalassemia/HbE erythroid cells

Sukanya Chumchuen, Orapan Sripichai, Natee Jearawiriyapaisarn, Suthat Fucharoen, Chayanon Peerapittayamongkol Abstract Imbalanced globin chain output contributes to thalassemia pathophysiology. Hence, induction of fetal hemoglobin in β-thalassemia and other β-hemoglobinopathies are of continuing interest for therapeutic approaches. Genome-wide association studies have identified three common genetic loci: namely β-globin (HBB), an intergenic region between MYB and HBS1L, […]

Real-world evidence of cisplatin versus carboplatin in patients with locally advanced nasopharyngeal carcinoma receiving concurrent chemoradiotherapy: A multicenter analysis

Arunee Dechaphunkul, Pongwut Danchaivijitr, Rungarun Jiratrachu, Tanadech Dechaphunkul, Chatsuda Sookthon, Chuleeporn Jiarpinitnun, Chatchanok Paoin, Jiraporn Setakornnukul, Bhoom Suktitipat, Poompis Pattaranutaporn, Nuttapong Ngamphaiboon Abstract Background: Though concurrent chemoradiotherapy (CCRT) with cisplatin remains a standard of care for patients with locally advanced nasopharyngeal carcinoma (LA-NPC), carboplatin has alternatively been used without sufficient supportive evidences. Thus, we evaluated […]

The KRAS-Mutant Consensus Molecular Subtype 3 Reveals an Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Pariyada Tanjak, Amphun Chaiboonchoe, Tharathorn Suwatthanarak, Onchira Acharayothin, Kullanist Thanormjit, Jantappapa Chanthercrob, Thanawat Suwatthanarak, Bundit Wannasuphaphol, Kemmapon Chumchuen, Bhoom Suktitipat, Somponnat Sampattavanich, Krittiya Korphaisarn, Ananya Pongpaibul, Naravat Poungvarin, Harald Grove, Woramin Riansuwan, Atthaphorn Trakarnsanga, Asada Methasate, Manop Pithukpakorn, Vitoon Chinswangwatanakul Abstract Colorectal cancers (CRC) with KRAS mutations (KRASmut) are frequently included in consensus molecular subtype […]

Validation of a Thai semiquantitative food frequency questionnaire (semi-FFQ) for people at risk of metabolic syndrome

Nattvara Nirdnoy, Kitti Sranacharoenpong, Apinya Surawit, Bonggochpass Pinsawas, Pichanun Mongkolsucharitkul, Tanyaporn Pongkunakorn, Thamonwan Manosan, Suphawan Ophakas, Sophida Suta, Sureeporn Pumeiam, Korapat Mayurasakorn; Siriraj Health Study Group Collaborators Siriraj Health Study Group : Winai Ratanasuwan, Mayuree Homsanit, Keerati Charoencholvanich, Bhoom Suktitipat, Chalermchai Mitrpant, Manop Pithukpakorn, Prapat Suriyaphol, Rungroj Krittayaphong, Prasert Auewarakul, Boonrat Tassaneetritap, Naravat Poungvarin Abstract […]

Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine

Vivek Bhakta Mathema, Partho Sen, Santosh Lamichhane, Matej Orešič, Sakda Khoomrung Abstract Cancer progression is linked to gene-environment interactions that alter cellular homeostasis. The use of biomarkers as early indicators of disease manifestation and progression can substantially improve diagnosis and treatment. Large omics datasets generated by high-throughput profiling technologies, such as microarrays, RNA sequencing, whole-genome […]