Published Fluid Therapy was a standard treatment for patients with septic shock. But, recent retrospective evidence suggests the efficacy of early norepinephrine administration during resuscitation. However, there was limited information from prospective randomization trials to support this postulation.
The research was set up to conduct a Randomized Control Trial to evaluate the hypothesis that early low-dose norepinephrine in adults with sepsis with hypotension increases shock control compared with standard care.
The results of this clinical trial demonstrated a significant association between early norepinephrine and increased shock control. Further studies are needed to confirm these findings before this approach can be introduced in clinical resuscitation practice. Future studies should investigate the effect of early norepinephrine on organ dysfunction and mortality.
