Pojsakorn Danpanichkul, Kwanjit Duangsonk, Agnes H Y Ho, Passisd Laoveeravat, Chawinthorn Vuthithammee, Disatorn Dejvajara, Vitchapong Prasitsumrit , Thanida Auttapracha, Busara Songtanin, Panu Wetwittayakhlang, Rashid N Lui, Gursimran Singh Kochhar, Siew C Ng, Francis A Farraye, Karn Wijarnpreecha Abstract Introduction: To update the global burden of inflammatory bowel disease (IBD) using data from the Global Burden […]
Category Archives: Research Innovation
Research Innovation
Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases
17
Dec
Dec
Chi Tian, Yuntian Zhang, Yihan Tong, Kian Hong Kock, Donald Yuhui Sim, Fei Liu, Jiaqi Dong, Zhixuan Jing, Wenjing Wang, Junbin Gao, Le Min Tan, Kyung Yeon Han, Yoshihiko Tomofuji, Masahiro Nakano, Eliora Violain Buyamin, Radhika Sonthalia, Yoshinari Ando, Hiroaki Hatano, Kyuto Sonehara; Asian Immune Diversity Atlas Network; Xin Jin, Marie Loh, John Chambers, Chung-Chau […]
Research Innovation
Cold-pressed extraction of perilla seed oil enriched with alpha-linolenic acid mitigates tumour progression and restores gut microbial homeostasis in the AOM/DSS mice model of colitis-associated colorectal cancer
17
Dec
Dec
Chawin Korsirikoon, Peerapa Techaniyom, Aikkarach Kettawan, Thanaporn Rungruang, Chanatip Metheetrairut , Pinidphon Prombutara, Aurawan Kringkasemsee Kettawan Abstract The present investigation explores into the influence of dietary nutrients, particularly alpha-linolenic acid (ALA), a plant-derived omega-3 fatty acid abundant in perilla seed oil (PSO), on the development of colitis-associated colorectal cancer (CRC). The study employs a mouse […]
Pichanun Mongkolsucharitkul, Apinya Surawit, Thamonwan Manosan, Suphawan Ophakas, Sophida Suta, Bonggochpass Pinsawas, Tanyaporn Pongkunakorn, Sureeporn Pumeiam, Winai Ratanasuwan, Mayuree Homsanit, Keerati Charoencholvanich, Yuthana Udomphorn, Bhoom Suktitipat, Korapat Mayurasakorn Abstract Background The study of non-communicable diseases (NCDs) in a developing country like Thailand has rarely been conducted in long-term cohorts, especially among the working-age population. We […]
Daniel A Acheampong , Piroon Jenjaroenpun , Thidathip Wongsurawat , Alongkorn Kurilung , Yotsawat Pomyen , Sangam Kandel , Pattapon Kunadirek , Natthaya Chuaypen , Kanthida Kusonmano , Intawat Nookaew Abstract Accurate taxonomic profiling of microbial taxa in a metagenomic sample is vital to gain insights into microbial ecology. Recent advancements in sequencing technologies have […]
Sasiwimon Utama, Jessica M. Cale, Chalermchai Mitrpant, Sue Fletcher, Steve D. Wilton, May T. Aung-Htut Abstract Vascular Ehlers–Danlos syndrome or Ehlers–Danlos syndrome type IV (vEDS) is a connective tissue disorder characterised by skin hyperextensibility, joint hypermobility and fatal vascular rupture caused by COL3A1 mutations that affect collagen III expression, homo-trimer assembly and secretion. Along with […]
Wichayapat Thongrattana , Tantip Arigul , Bhoom Suktitipat , Manop Pithukpakorn , Sith Sathornsumetee , Thidathip Wongsurawat , Piroon Jenjaroenpun Abstract Summary The revised WHO guidelines for classifying and grading brain tumors include several copy number variation (CNV) markers. The turnaround time for detecting CNVs and alterations throughout the entire genome is drastically reduced with […]
Research Innovation
Epigallocatechin Gallate Potentiates the Anticancer Effect of AFP-siRNA-Loaded Polymeric Nanoparticles on Hepatocellular Carcinoma Cells
17
Dec
Dec
Kamonlatth Rodponthukwaji, Ponpawee Pingrajai, Saranrat Jantana, Seri Taya, Kongpop Duangchan, Kytai T Nguyen, Chatchawan Srisawat , Primana Punnakitikashem Abstract To develop a potential cancer treatment, we formulated a novel drug delivery platform made of poly(lactic-co-glycolic) acid (PLGA) and used a combination of an emerging siRNA technology and an extracted natural substance called catechins. The synthesized […]
Research Innovation
Accurate Prediction of Ion Mobility Collision Cross-Section Using Ion’s Polarizability and Molecular Mass with Limited Data
17
Dec
Dec
Pattipong Wisanpitayakorn, Sitanan Sartyoungkul, Alongkorn Kurilung, Yongyut Sirivatanauksorn, Wonnop Visessanguan , Nuankanya Sathirapongsasuti, Sakda Khoomrung Abstract The rotationally averaged collision cross-section (CCS) determined by ion mobility-mass spectrometry (IM-MS) facilitates the identification of various biomolecules. Although machine learning (ML) models have recently emerged as a highly accurate approach for predicting CCS values, they rely on large […]
Research Innovation
Comparative quantitative trait loci analysis framework reveals relationships between salt stress responsive phenotypes and pathways
17
Dec
Dec
Sunadda Phosuwan, Noppawan Nounjan, Piyada Theerakulpisut, Meechai Siangliw, Varodom Charoensawan Abstract Soil salinity is a complex abiotic stress that involves several biological pathways. Hence, focusing on a specific or a few salt-tolerant phenotypes is unlikely to provide comprehensive insights into the intricate and interwinding mechanisms that regulate salt responsiveness. In this study, we develop a […]
