Paravee Own-Eium, Donniphat Dejsuphong, Prin Vathesatogkit, Piyamitr Sritara, Thanyachai Sura, Wichai Aekplakorn, Bhoom Suktitipat, Jakris Eu-Ahsunthornwattana Abstract Wilson’s disease (WD) is a rare metabolic disorder caused by variations in the ATP7B gene. It usually manifests hepatic, neurologic, and psychiatric symptoms due to excessive copper accumulation. The prevalence of WD and its common variants differ across […]
Category Archives: Research Innovation
Research Innovation
Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues
17
Dec
Dec
Yoshihiko Tomofuji, Ryuya Edahiro, Kyuto Sonehara, Yuya Shirai, Kian Hong Kock, Qingbo S Wang, Shinichi Namba, Jonathan Moody, Yoshinari Ando, Akari Suzuki, Tomohiro Yata, Kotaro Ogawa, Tatsuhiko Naito, Ho Namkoong, Quy Xiao Xuan Lin, Eliora Violain Buyamin, Le Min Tan, Radhika Sonthalia, Kyung Yeon Han, Hiromu Tanaka, Ho Lee; Asian Immune Diversity Atlas (AIDA) Network; […]
Research Innovation
Development of cancer-associated fibroblasts-targeting polymeric nanoparticles loaded with 8-O-methylfusarubin for breast cancer treatment
17
Dec
Dec
Kamonlatth Rodponthukwaji, Suyanee Thongchot, Suttikiat Deureh, Tanva Thongkleang, Mattika Thaweesuvannasak, Kornrawee Srichan, Chatchawan Srisawat , Peti Thuwajit, Kytai T. Nguyen, Kwanruthai Tadpetch, Chanitra Thuwajit, Primana Punnakitikashem Abstract Cancer-associated fibroblasts (CAFs) are abundant stromal cells residing in a tumor microenvironment (TME) which are associated with the progression of tumor. Herein, we developed novel CAFs-targeting polymeric nanoparticles […]
Research Innovation
Immunogenicity of intraperitoneal and intranasal liposome adjuvanted VLP vaccines against SARS-CoV-2 infection
17
Dec
Dec
Monrat Chulanetra, Primana Punnakitikashem, Kodchakorn Mahasongkram, Wanpen Chaicumpa, Kantaphon Glab-Ampai Abstract Humans get SARS-CoV-2 infection mainly through inhalation; thus, vaccine that induces protective immunity at the virus entry site is important for early control of the infection. In this study, two anionic liposome (L)-adjuvanted VLP vaccines against SARS-CoV-2 were formulated. Baculovirus-Sf21 insect cell system was […]
Research Innovation
Characterization of airborne microbial communities in northern Thailand: Impacts of smoke haze versus non-haze conditions
17
Dec
Dec
Nuttipon Yabueng, Chakriya Sansupa, Nuttapol Noirungsee, Pavidarin Kraisitnitikul, Sarana Chansuebsri, Radshadaporn Janta, Sakda Khoomrung, Terd Disayathanoowat, Somporn Chantara Abstract Data on airborne microorganisms, particularly in Southeast Asia, are more limited compared to chemical data. This study is the first to examine the community and diversity of microorganisms on PM2.5 in an urban area of Northern […]
Research Innovation
Prostaglandin E2-EP2/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells
17
Dec
Dec
Siwakorn Punyawatthananukool, Ryuma Matsuura, Thamrong Wongchang , Nao Katsurada, Tatsuaki Tsuruyama, Masaki Tajima, Yutaka Enomoto, Toshio Kitamura, Masahiro Kawashima, Masakazu Toi, Koji Yamanoi, Junzo Hamanishi, Shigeo Hisamori, Kazutaka Obama, Varodom Charoensawan, Dean Thumkeo, Shuh Narumiya Abstract While prostaglandin E2 (PGE2) is produced in human tumor microenvironment (TME), its role therein remains poorly understood. Here, we […]
Research Innovation
MSC secretome from amniotic fluid halts IL-1β and TNF-α inflammation via the ERK/MAPK pathway, promoting cartilage regeneration in OA in vitro
17
Dec
Dec
Supatra Klaymook, Napatara Tirawanchai, Suparat Wichitwiengrat, Puttachart Chuaynarong, Sasiprapa Thongbopit, Keerati Chareancholvanich, Tatsanee Phermthai Abstract Osteoarthritis (OA) is a degenerative disease that causes chronic pain and disability worldwide. This disease is mainly caused by IL-1β and TNF-α, which lead to cartilage degradation and inhibit the repair capacity of damaged cartilage. Recent studies have shown that […]
Research Innovation
Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression
17
Dec
Dec
Kongpop Duangchan, Nathachit Limjunyawong, Kamonlatth Rodponthukwaji, Teeranai Ittiudomrak, Mattika Thaweesuvannasak, Natsuda Kunwong, Chanatip Metheetrairut , Vorapan Sirivatanauksorn , Yongyut Sirivatanauksorn, Prawat Kositamongkol, Prawej Mahawithitwong, Chutwichai Tovikkai, Kytai T Nguyen, Chatchawan Srisawat , Primana Punnakitikashem Abstract α-Fetoprotein (AFP) is an oncogenic glycoprotein that is overexpressed in most patients with liver cancer. Moreover, it significantly affects tumorigenesis […]
Cheerasook Chongkolwatana, Paiboon Sureepong, Kunkanya Chansomboon, Navarat Kasemsuk, Chatchawan Srisawat Abstract Objective: This study aimed to compare the cerumenolytic efficacy of 2.5 % sodium bicarbonate prepared in-house with that of commercially available 0.5 % sodium docusate, utilizing cerumen weight gain and disintegration degree as metrics. Methods: Cerumen samples were collected from patients at an otorhinolaryngology […]
Research Innovation
Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1
17
Dec
Dec
Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat , Sittiruk Roytrakul, Stephan A Bäurle, Sansanee Noisakran Abstract Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of […]
