Category Archives: Research Innovation

Natnicha Jiravejchakul, Wilawan Chan-In, Walairat Thuncharoen; DENFREE Thailand; Waradon Sungnak, Varodom Charoensawan , Vimvara Vacharathit, Ponpan Matangkasombut Abstract Dengue is an important tropical disease with considerable global impact. Despite this, there remains an urgent need for reliable biomarkers to predict disease severity, as well as effective antiviral drugs and targeted treatments. In this study, we […]

Kanika Saxena, Rebecca Andersson, Per O Widlund, Sakda Khoomrung, Sarah Hanzén, Jens Nielsen, Navinder Kumar, Mikael Molin, Thomas Nyström Abstract Cellular protein homeostasis relies on a complex network of protein synthesis, folding, sub-cellular localization, and degradation to sustain a functional proteome. Since most of these processes are energy-driven, proteostasis is inescapably afflicted by cellular metabolism. […]

Nalumon Thadtapong, Varodom Charoensawan, Vanvimon Saksmerprome, Soraya Chaturongakul Abstract Vibrio parahaemolyticus (VP) is a major bacterial species that causes early mortality syndrome (EMS) in shrimps. EMS can be classified into two groups based on histological signs of hepatopancreatic tissues, i.e., acute hepatopancreatic necrosis disease (AHPND) and non-AHPND. To investigate how toxin-producing AHPND and toxin-lacking non-AHPND […]

Korawit Opassathian, Nawarat Boonmee, Saowanee Swangkaew, Piroon Jenjaroenpun, Thidathip Wongsurawat, Worarat Kruasuwan, Popchai Ngamskulrungroj, Chalermchai Mitrpant Abstract Candida auris, one of the emerging multidrug-resistant Candida species, was first discovered in 2009 from the ear canal of a patient in Tokyo, Japan. Since then, several studies exhibit the possible threats of C. auris due to its […]

Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol Abstract Leber’s hereditary optic neuropathy (LHON) is a maternally inherited disorder caused by mitochondrial DNA mutations in complex I of the respiratory chain, leading to impaired ATP production, mitochondrial fragmentation, and oxidative stress that contribute to vision loss. This study investigated the potential repurposing of metformin, a […]

Wichian Sangwongchai, Kwanjeera Wanichthanarak, Ammarin In-on, Supidcha Natee, Chamaiporn Champasri, Nutcha Sa-ingthong, Diane M. Beckles, Sakda Khoomrung, Maysaya Thitisaksakul Abstract The starch and protein in rice grains determine their nutritional value, eating and cooking quality (ECQ), and potential applications as a biopolymer. Building on previously identified functional differences between two Thai indica cultivars, waxy RD6 […]

Pattipong Wisanpitayakorn, Adchata Konsue, Thanutchaporn Sartyoungkul, Ammarin In-On, Yongyut Sirivatanauksorn, David R Gang, Prasat Kittakoop, Sakda Khoomrung Abstract Conventional mass spectrometry imaging (MSI), even when combined with low-resolution ion mobility, lacks the resolving power to distinguish stereoisomers. To address this limitation, we developed a high-resolution desorption electrospray ionization cyclic ion mobility mass spectrometry (DESI-cIM-MS) method […]

Weerawan Manokasemsan, Narumol Jariyasopit, Kwanjeera Wanichthanarak, Patcha Poungsombat, Alongkorn Kurilung, Suphitcha Limjiasahapong, Kajol Thapa, Yongyut Sirivatanauksorn, Sukit Raksasuk, Thatsaphan Srithongkul, Chagriya Kitiyakara, Sakda Khoomrung Abstract We developed a robust LC–MS/MS method for the simultaneous quantification of 16 uremic toxins (UTs) and 14 bile acids (BAs) in plasma and fecal samples within a single method. The […]

Lucksamon Thamlikitkul, Kwanjeera Wanichthanarak, Siriphan Manocheewa, Suphitcha Limjiasahapong, Natthaporn Phonsatta, Sujichon Thangvichien, Atikorn Panya, Yongyut Sirivatanauksorn, Naravat Poungvarin, Sakda Khoomrung Abstract Lung cancer remains the leading cause of cancer-related mortality worldwide, underscoring the urgent need for non-invasive approaches to improve diagnosis, patient stratification, and therapeutic monitoring. Metabolic reprogramming driven by oncogenic alterations-particularly Epidermal Growth Factor […]

Jantarika Kumar Arora, Louisa K James, Varodom Charoensawan Abstract Droplet-based single-cell RNA sequencing (scRNA-seq) frequently encounters significant challenges from contamination of cell-free mRNAs, known as “ambient mRNAs”, which can substantially distort single-cell transcriptome data interpretation to a large extent. In this study, we investigate the impact of ambient mRNA contamination on differential gene expression and […]