Janya Grainok, Ianthe L. Pitout, Fred K. Chen, Samuel McLenachan, Rachael C. Heath Jeffery, Chalermchai Mitrpant, Sue Fletcher Abstract Retinitis pigmentosa 11 is an untreatable, dominantly inherited retinal disease caused by heterozygous mutations in pre-mRNA processing factor 31 PRPF31. The expression level of PRPF31 is linked to incomplete penetrance in affected families; mutation carriers with […]
Category Archives: Research Innovation
Kwanjeera Wanichthanarak , Ammarin In-on , Sili Fan , Oliver Fiehn , Arporn Wangwiwatsin , Sakda Khoomrung Abstract In classic semiquantitative metabolomics, metabolite intensities are affected by biological factors and other unwanted variations. A systematic evaluation of the data processing methods is crucial to identify adequate processing procedures for a given experimental setup. Current comparative […]
Research Innovation
Angiotensin II promotes erythroid proliferation in a three-stage erythroid culture system
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Dec
Saiphon Poldee , Chanatip Metheetrairut , Wichit Suthammarak, Kongtana Trakarnsanga Abstract At present, the numbers of cultured erythroid cells obtained from culture systems are not on a scale that can be used for therapeutics since the cultured erythroid cells have limited proliferation capacity. Stromal cells are believed to play important roles during erythropoiesis. Our previous […]
Research Innovation
Transcriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells
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Dec
Jiraporn Jantaravinid, Napatara Tirawanchai, Sumate Ampawong, Kanchana Kengkoom, Anchaleekorn Somkasetrin, Vorthunju Nakhonsri, Pornanong Aramwit Abstract Sericin, a natural protein derived from Bombyx mori, is known to ameliorate liver tissue damage; however, its molecular mechanism remains unclear. Herein, we aimed to identify the possible novel targets of sericin in hepatocytes and related cellular pathways. RNA sequencing […]
Research Innovation
Single-cell RNA sequencing reveals the expansion of circulating tissue-homing B cell subsets in secondary acute dengue viral infection
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Dec
Dec
Jantarika Kumar Arora, Ponpan Matangkasombut, Varodom Charoensawan, Anunya Opasawatchai; DENFREE Thailand Collaborators DENFREE Thailand : Anavaj Sakuntabhai, Pratap Singhasivanon, Swangjit Suraamornkul, Tawatchai Yingtaweesak, Khajohnpong Manopwisedjaroen, Nada Pitabut Abstract The roles of antibodies secreted by subsets of B cells in dengue virus (DENV) infection have been extensively studied, yet, the contribution of tissue-homing B cells to […]
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Dec
Weerawan Manokasemsan, Narumol Jariyasopit, Patcha Poungsombat, Khwanta Kaewnarin, Kwanjeera Wanichthanarak, Alongkorn Kurilung, Kassaporn Duangkumpha, Suphitcha Limjiasahapong, Yotsawat Pomyen, Roongruedee Chaiteerakij, Rossarin Tansawat, Chatchawan Srisawat, Yongyut Sirivatanauksorn, Vorapan Sirivatanauksorn, Sakda Khoomrung Abstract Short-chain fatty acids (SCFAs) are involved in important physiological processes such as gut health and immune response, and changes in SCFA levels can be […]
Research Innovation
Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples
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Dec
Dec
Alongkorn Kurilung, Suphitcha Limjiasahapong, Khwanta Kaewnarin, Pattipong Wisanpitayakorn, Narumol Jariyasopit, Kwanjeera Wanichthanarak, Sitanan Sartyoungkul, Stephen Choong Chee Wong, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara, Yongyut Sirivatanauksorn, Sakda Khoomrung Abstract The collision cross-sections (CCS) measurement using ion mobility spectrometry (IMS) in combination with mass spectrometry (MS) offers a great opportunity to increase confidence in metabolite identification. However, owing […]
Khajeelak Chiablaem, Artit Jinawath, Jiratchaya Nuanpirom, Jantarika Kumar Arora, Sirawit Nasaree, Thanastha Thanomchard, Nilubon Singhto, Pamorn Chittavanich, Bhoom Suktitipat , Varodom Charoensawan, Arthit Chairoungdua, Jim Jinn-Chyuan Sheu, Kazuma Kiyotani, Jisnuson Svasti, Yusuke Nakamura, Natini Jinawath Abstract Intrahepatic cholangiocarcinoma (ICC) is a lethal cancer with poor survival especially when it spreads. The histopathology of its rare […]
Research Innovation
Identification of Candidate Genes for Salt Tolerance at Seedling Stage in Rice Using QTL-Seq and Chromosome Segment Substitution Line-Derived Population
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Dec
Dec
Jiraporn Leawtrakun, Wanchana Aesomnuk, Srisawat Khanthong, Reajina Dumhai, Decha Songtoasesakul, Sunadda Phosuwan, Jiratchaya Nuanpirom, Varodom Charoensawan, Jonaliza L. Siangliw, Vinitchan Ruanjaichon, Theerayut Toojinda, Samart Wanchana, Meechai Siangliw, Siwaret Arikit Abstract Rice is a staple food for more than half of the world’s population. However, the pervasive problem of salinity is severely undermining rice production, especially […]
Sanya Sureram, Nopporn Chutiwitoonchai, Tam Pooprasert, Watchara Sangsopha, Suphitcha Limjiasahapong, Narumol Jariyasopit, Yongyut Sirivatanauksorn, Sakda Khoomrung, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Abstract Kratom, Mitragyna speciosa, is one of the most popular herbs in the West and Southeast Asia. A number of previous works have focused on bioactive alkaloids in this plant; however, non-alkaloids have […]
