Division of Pediatric Endocrinology

1. Staff

No.		Name-surname	Academic position/position
Advisor
1.		Supawadee Likitmaskul, M.D.	Clin. Prof. of Pediatrics Diplomate of the Thai Board of Pediatrics Certificate of Pediatric Endocrinology, Thai Medical Council Certificate of Pediatric Endocrinology (The Ray William Institution of Endocrinology and Diabetology. The Children’s Hospital, Sydney, Australia)
2.		Pairunyar Nakavachara, M.D.	Professor of Pediatrics Diplomate of the American Board of Pediatrics, The University of Illinois, Chicago, Illinois, USA Diplomate of the American Subboard of Pediatric Endocrinology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Academic staff
1.		Jeerunda Santiprabhob, M.D. (Chief of Division)	Associate Professor of Pediatrics Diplomate of the American Board of Pediatrics, The University of Illinois, Chicago, Illinois, USA Diplomate of the American Subboard of Pediatric Endocrinology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA
2.		Supitcha Patjamontri, M.D.	Assistant Professor of Pediatrics Diplomate of the Thai Board of Pediatrics Diplomate of the Thai Subboard of Pediatric Endocrinology
3.		Ornsuda Lertbannaphong, M.D.	Lecturer of Pediatrics Diplomate of the American Board of Pediatrics, The University of Illinois, Chicago, Illinois, USA Diplomate of the American Subboard of Pediatric Endocrinology, Children’s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
4.		Janehira Sae-wong, M.D.	Lecturer of Pediatrics
Support staff
1.		Mrs.Katharee Chaichanwattanakul	Adviser, Medical Scientist
2.		Miss Pornpimol Kiattisakthavee	Registered Nurse
3.		Miss Praewvarin Weerakulwattana	Research Technical Officer
4.		Miss Teerarat Manpayak	Medical Scientist
5.		Miss Parichat Netsakulnee	Medical Scientist
6.		Miss Yupin Phujomjai	Medical Scientist
7.		Miss Amornrat Pipatsathian	Research Officer
8.		Miss Thamita Thirachanakamon	General  Service Officer  (DM Call Center)
9.		Miss Ketmanee Lohavimon	General  Service Officer

Pediatric Endocrinology Clinic

Our outpatient care is located at the 1st floor of the HRH Princess Mahachakri Building. The health care provider team consists of faculty members, clinical fellows, nurses, pharmacists, dietician and well-trained technicians. Our service provides approximately ~3,700 visits per year.   Endocrinology Clinic: Wednesday 1 PM-4 PM   DM Clinic: Thursday 9 AM-12 PM

Services in the outpatient clinic include

• Comprehensive work up and care for children with endocrine problems
  • Adrenal gland disorders
    • Premature Adrenarche
    • Congenital adrenal hyperplasia
    • Cushing Syndrome
    • Addison Disease
    • Adrenal tumors
  • Bone and calcium disorders
    • Disorders of calcium metabolism
    • Osteoporosis
    • Rickets
    • Osteogenesis imperfecta
  • Growth disorders
  • Pituitary gland disorders
    • Panhypopituitarism
  • Hypoglycemia
  • Diabetes mellitus
  • Puberty disorders
    • Premature adrenarche
    • Premature thelarche
    • Precocious Puberty
    • Delayed puberty
    • Polycystic ovary syndrome
  • Thyroid disease
    • Congenital and acquired hypothyroidism
    • Goiter
    • Hyperthyroidism
  • Certain genetic disorders
    • Turner Syndrome
    • Klinefelter’s Syndrome

Inpatient Pediatric Endocrinology Service

The pediatric endocrinology service provides the most comprehensive care with high standard. We provide superb level of investigation and management to our patients. The inpatient unit locates on several pediatric wards. The admission is approximately 600 / year.

Special endocrine tests

Our division provides special endocrine tests for diagnostic purposes. The tests are performed by physicians and well-trained nurses. The special endocrine tests are listed as follow:

• • Insulin tolerance test
  • Clonidine test
  • Oral glucose tolerance test
  • ACTH stimulation test
  • hCG stimulation test
  • Water deprivation test
  • Special laboratory tests
    • Serum growth hormone
    • Serum IGF-1
    • Serum 17 –OH progesterone
    • Serum leptin
    • Anti GAD
    • IA2
    • Genetic study : CYP21A1,SRDSA2, AR genes
  • Other services:
    • Diabetes intensive management service including continuous glucose monitoring system (CGMS) for DM patients, intensive DM self-care teaching
    • Demonstration of growth hormone injection technique to patients

Siriraj Pediatric Diabetes Call Center

Siriraj Pediatric Diabetes Call Center is a service providing diabetes education and counseling for intensive diabetes control. It is located on the 9th floor of Anandamahidol Building. Diabetes Call Center contact number:
Tel and Fax: 02-419-7000 ext 5837
E-mail: dmcenter@diamond.mahidol.ac.th

Pediatric Diabetes Hot line:

In case of emergency, patients with diabetes can contact on-call nurses 24 hours via mobile phone 081-906-0886.

Research and area of interest

• • • Type 1 DM and Type 2 DM in children and adolescents
    • Obesity and metabolic syndrome in children and adolescents
    • Endocrine complications of thalassemia in children (transfusion-dependent and non-transfusion dependent)

Fellowship Program

Our Pediatric Endocrinology Fellowship is a two-year fellowship program. The program is designed to prepare qualified applicants to practice the clinical science of Pediatric Endocrinology and to develop an area of expertise in clinical research. Interested applicants may request additional information by contacting the division (Tel 02-419-7000 ext 5676).

Publication by Pairunyar Nakavachara, M.D.

• • 1. Nakavachara P, Petchkul J, Jeerawongpanich K, Kiattisakthavee P, Manpayak T, Netsakulnee P, Chaichanwattanakul K, Pooliam J, Srichairatanakool S, Viprakasit V. Prevalence of low bone mass among adolescents with nontransfusion-dependent hemoglobin E/β-thalassemia and its relationship with anemia severity. Pediatr Blood Cancer. 2017 Aug 12. doi: 10.1002/pbc.26744. [Epub ahead of print]
    2. Nakavachara P, Pooliam J, Weerakulwattana L, Manorompatarasarn R, Kiattisakthavee P, Chaichanwattanakul K, et al. A normal reference of bone mineral density (BMD) measured by dual energy x-ray absorptiometry in healthy Thai children and adolescents aged 5-18 years: a new reference for Southeast Asian populations. PLoS One. 2014;9(5):e97218.doi:10.1371/journal. pone.0097218.
    3. Nakavachara P, Viprakasit V. Adrenal insufficiency is prevalent in HbE/β-thalassaemia paediatric patients irrespective of their clinical severity and transfusion requirement. Clin Endocrinol (Oxf) 2013;79(6):776-83.
    4. Nakavachara P, Viprakasit V. Children with hemoglobin E/β-thalassemia have a high risk of being vitamin D deficient even if they get abundant sun exposure: a study from Thailand. Pediatr Blood Cancer 2013;60(10):1683-8.
    5. Sawathiparnich P, Sitthinamsuwan P, Sanpakit K, Laohapensang M, Chuangsuwanich T. Cushing’s syndrome caused by an ACTH-producing ovarian steroid cell tumor, NOS, in a prepubertal girl. Endocrine 2009;35(2):132-5.
    6. Sawathiparnich P, Sumboonnanonda A, Weerakulwattana P, Limwongse C. A novel mutation in the β-subunit of the epithelial sodium channel gene (SCNN1B) in a Thai family with Liddle’s Syndrome. J Pediatr Endocrinol Metab 2009;22(1):85-9.
    7. Osuwannaratana P, Nimkarn S, Santiprabhob J, Likitmaskul S, Sawathiparnich P. The etiologies of adrenal insufficiency in 73 Thai children: 20 years experience. J Med Assoc Thai 2008;91(10):1544-50.
    8. Harinsoot Somnuke P, Pusuwan P, Likitmaskul S, Santiprabhob J, Sawathiparnich P. Treatment outcome of Graves’ disease in Thai children. J Med Assoc Thai. 2007;90(9):1815-20.
    9. Sawathiparnich P, Osuwannaratana P, Santiprabhob J, Likitmaskul S. Tamoxifen improved final height prediction in a girl with McCune–Albright syndrome, a case report and literature review. J Pediatr Endocrinol Metab 2006;19:81-6.
    10. Sanmaneechai O, Wisuthsarewong W, Sawathiparnich P. Epidermal nevus syndrome presenting as hypophosphatemic rickets: a case report of uncommon association. The Endocrinologists 2006;16:145-9.
    11. Sawathiparnich P, Weerakulwattana L, Santiprabhob P, Likitmaskul S. Obese adolescent girls with polycystic ovary syndrome (PCOS) have more severe insulin resistance measured by HOMA-IR score than obese girls without PCOS. J Med Assoc Thai 2005;88:33-7.
    12. Sawathiparnich P, Kiattisakthavee P, Santiprabhob J, Likitmaskul S. Preliminary data of insulin glargine use among Thai adolescents and young adults with type 1 diabetes mellitus treated at Siriraj Hospital. J Med Assoc Thai 2005;88:48-52.
    13. Sawathiparnich P, Murphey LJ, Kumar S, Vaughan DE, Brown NJ. Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1. J Clin Endocrinol Metab 2003; 88:3867-73.
    14. Sawathiparnich P, Kumar S, Vaughan DE, Brown NJ. Spironolactone abolishes the relationship between aldosterone and PAI-1 in humans. J Clin Endocrinol Metab 2002;87:448-52.
    15. Sawathiparnich P, Likitmaskul S, Angsusingha K, Nimkarn S, Chaichanwatanakul K, Laohapansang M, et al. Persistent hyperinsulinemic hypoglycemia of infancy: experience at Siriraj Hospital. J Med Assoc Thai 2002;85(Suppl 2):S506-12.

Publication by Supawadee Likitmaskul, M.D.

• • 1. Santiprabhob J, Leewanun C, Limprayoon K, Kiattisakthavee P, Wongarn R, Aanpreung P, Likitmaskul S. Outcomes of group-based treatment program with parental involvement for the management of childhood and adolescent obesity. Patient Educ Couns. 2014 Oct;97(1):67-74. doi: 10.1016/j.pec.2014.07.002. Epub 2014 Jul 11.
    2. Numbenjapon N, Nakavachara P, Santiprabhob J, Kiattisakthavee P, Wongarn R, Likitmaskul S. Successful strategy to improve glucose tolerance in Thai obese youth. J Med Assoc Thai. 2010 Nov;93 Suppl 6:S131-8.
    3. Santiprabhob J, Weerakulwattana P, Nunloi S, Kiattisakthavee P, Wongarn R, Wekawanich J, Nakavachara P, Chaichanwattanakul K, Likitmaskul S. Etiology and glycemic control among Thai children and adolescents with diabetes mellitus. J Med Assoc Thai. 2007 Aug;90(8):1608-15.
    4. Likitmaskul S, Wacharasindhu S, Rawdaree P, Ngarmukos C, Deerochanawong C, Suwanwalaikorn S, Chetthakul T, Bunnag P, Kosachunhanun N, Plengvidhaya N, Leelawatana R, Krittiyawong S, Benjasuratwong Y, Pratipanawatr T. Thailand diabetes registry project: type of diabetes, glycemic control and prevalence of microvascular complications in children and adolescents with diabetes. J Med Assoc Thai. 2006 Aug;89 Suppl 1:S10-6.
    5. Likitmaskul S, Santiprabhob J, Sawathiparnich P, Numbenjapon N, Chaichanwatanakul K. Clinical pictures of type 2 diabetes in Thai children and adolescents is highly related to features of metabolic syndrome. J Med Assoc Thai. 2005 Nov;88 Suppl 8:S169-75.
    6. Sawathiparnich P, Kiattisakthavee P, Santiprabhob J, Likitmaskul S. Preliminary data of insulin glargine use among Thai adolescents and young adults with type 1 diabetes mellitus treated at Siriraj Hospital. J Med Assoc Thai. 2005 Nov;88 Suppl 8:S48-52.
    7. Sawathiparnich P, Weerakulwattana L, Santiprabhob J, Likitmaskul S. Obese adolescent girls with polycystic ovary syndrome (PCOS) have more severe insulin resistance measured by HOMA-IR score than obese girls without PCOS. J Med Assoc Thai. 2005 Nov;88 Suppl 8:S33-7.
    8. Sawathiparnich P, Osuwanaratana P, Santiprabhob J, Likitmaskul S. Tamoxifen improved final height prediction in a girl with McCune-Albright syndrome: patient report and literature review. J Pediatr Endocrinol Metab. 2006 Jan;19(1):81-6. Review.
    9. Likitmaskul S, Kiattisathavee P, Chaichanwatanakul K, Punnakanta L, Angsusingha K, Tuchinda C. Increasing prevalence of type 2 diabetes mellitus in Thai children and adolescents associated with increasing prevalence of obesity. J Pediatr Endocrinol Metab. 2003 Jan;16(1):71-7.
    10. Likitmaskul S, Wekawanich J, Wongarn R, Chaichanwatanakul K, Kiattisakthavee P, Nimkarn S, Prayongklin S, Weerakulwattana L, Markmaitree D, Ritjarean Y, Pookpun W, Punnakanta L, Angsusingha K, Tuchinda C. Intensive diabetes education program and multidisciplinary team approach in management of newly diagnosed type 1 diabetes mellitus: a greater patient benefit, experience at Siriraj Hospital. J Med Assoc Thai. 2002 Aug;85 Suppl 2:S488-95.
    11. Likitmaskul S, Angsusingha K, Morris S, Kiattisakthavee P, Chaichanwatanakul K, Tuchinda C. Type 1 diabetes in Thai children aged 0-14 years. J Med Assoc Thai. 1999 Aug;82(8):826-32.
    12. Likitmaskul S, Watcharasindhu S, Angsusingha K, Chaichanwatanakul K, Punnakunta L, Tuchinda C. IGF-1 generation test in non-growth hormone-deficient short children. Horm Res. 1998;49 Suppl 1:52.
    13. Likitmaskul S, Cowell CT, Donaghue K, Kreutzmann DJ, Howard NJ, Blades B, Silink M. ‘Exaggerated adrenarche’ in children presenting with premature adrenarche. Clin Endocrinol (Oxf). 1995 Mar;42(3):265-72.

Publication by Jeerunda Santiprabhob, M.D.

• • 1. Santiprabhob J, Tanchaweng S, Maturapat S, Maleesatharn A, Lermankul W, Sricharoenchai S, Wittawatmongkol O, Lapphra K, Phongsamart W, Chokephaibulkit K. Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors. Biomed Res Int. 2017;2017:7481597. doi: 10.1155/2017/7481597. Epub 2017 Feb 15.
    2. Santiprabhob J, Leewanun C, Limprayoon K, Kiattisakthavee P, Wongarn R, Aanpreung P, Likitmaskul S. Outcomes of group-based treatment program with parental involvement for the management of childhood and adolescent obesity. Patient Educ Couns. 2014 Oct;97(1):67-74. doi: 10.1016/j.pec.2014.07.002. Epub 2014 Jul 11.
    3. Kulanuwat S, Phonrat B, Tungtrongchitr A, Limwongse C, Chongviriyaphan N, Tungtrongchitr R, Santiprabhob J. Effects of PCSK1 genetic variants on obesity among Thai children and their family members: in relation to health risk, and biochemical and anthropometric parameters. Southeast Asian J Trop Med Public Health. 2014 Jan;45(1):214-25.
    4. Santiprabhob J, Kiattisakthavee P, Likitmaskul S, Chaichanwattanakul K, Wekawanich J, Dumrongphol H, Sriwijitkamol A, Peerapatdit T, Nitiyanant W. Glycemic control, quality of life and self-care behavior among adolescents with type 1 diabetes who attended a diabetes camp. Southeast Asian J Trop Med Public Health. 2012 Jan;43(1):172-84.
    5. Santiprabhob J, Likitmaskul S, Kiattisakthavee P, Weerakulwattana P, Chaichanwattanakul K, Nakavachara P, Peerapatdit T, Nitiyanant W. Glycemic control and the psychosocial benefits gained by patients with type 1 diabetes mellitus attending the diabetes camp. Patient Educ Couns. 2008 Oct;73(1):60-6. doi: 10.1016/j.pec.2008.05.023. Epub 2008 Jul 7.
    6. Santiprabhob J, Weerakulwattana P, Nunloi S, Kiattisakthavee P, Wongarn R, Wekawanich J, Nakavachara P, Chaichanwattanakul K, Likitmaskul S. Etiology and glycemic control among Thai children and adolescents with diabetes mellitus. J Med Assoc Thai. 2007 Aug;90(8):1608-15.
    7. Santiprabhob J, Likitmaskul S, Sriwijitkamol A, Peerapatdit T, Sawathiparnich P, Nitiyanant W, Angsusingha K, Tuchinda C, Tandhanand S. Improved glycemic control among Thai children and young adults with type 1 diabetes participating in the diabetes camp. J Med Assoc Thai. 2005 Nov;88 Suppl 8:S38-43.
    8. Santiprabhob J, Likitmaskul S, Boonyasiri A, Boonsathorn S, Buddawong T. Etiologies of central diabetes insipidus in Thai children. J Pediatr Endocrinol Metab. 2005 Jul;18(7):653-61.
    9. Santiprabhob J, Browning J, Repaske D. A missense mutation encoding Cys73Phe in neurophysin II is associated with autosomal dominant neurohypophyseal diabetes insipidus. Mol Genet Metab. 2002 Sep-Oct;77(1-2):112-8.

Awards

• The best diabetic team 2015, Thai diabetes society, “King’s birthday 84 year old project, gathering for type 1 diabetes patients 5 December 2011” (Supawadee Likitmaskul et al.)
• Routine to Research (R2R) Award 2014, Faculty of Medicine Siriraj Hospital, Mahidol University “A normal reference of bone mineral density (BMD) measured by dual energy x-ray absorptiometry in healthy Thai children and adolescents aged 5-18 years: a new reference for Southeast Asian populations” (Pairunyar Nakavachara et al.)
• The Award of excellent for poster presentation in the International Conference in Medicine and Public Health: SICMPH 2014 “Vitamin D status among obese children and adolescent and effect of weight loss” (Jeerunda Santiprabhob et al.)
• The best clinical research 2014 “Outcome of group-based treatment program with parental involvement for the management of children and adolescent obesity” (Jeerunda Santiprabhob et al.)
• The best innovation and the best research reward 2013, Faculty of Medicine Siriraj Hospital, Mahidol University “Diabetes education tool: DM wonder trip” (Supawadee Likitmaskul et al.)
• The best implement of the year 2008 and Routine to Research (R2R) award 2009, Faculty of Medicine Siriraj Hospital, Mahidol University “Siriraj pediatric diabetes self management education and care program” (Supawadee Likitmaskul et al.)
• The best health care provider team 2005, Faculty of Medicine Siriraj Hospital, Mahidol University (Supawadee Likitmaskul et al.

Contact

Office : HRH. Princess Mahachakri Building,9^th floor

Tel : 02-4197000 Ext. 5676, 5977

FAX: 0-2419-7000 Ext. 5676