Introducing Metabox 2.0: Advancing Quantitative Metabolomics

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Exciting news! Dr. Kwanjeera Wanichthanarak and Assoc. Prof. Dr. Sakda Khoomrung from the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine, Siriraj Hospital, Mahidol University, have just published groundbreaking research in the Journal of GigaScience on March 15, 2024.

Their study, focusing on data processing solutions to enhance the quantitative nature of metabolomics, offers invaluable insights for both food and clinical metabolomics. By evaluating various data processing methods, including an examination of data distribution characteristics and fold difference patterns between metabolites, the team has introduced Metabox 2.0. This powerful tool facilitates thorough metabolomic data analysis, from processing to biomarker analysis, integrative analysis, and data interpretation.

Access the publication here: https://academic.oup.com/gigascience/article/doi/10.1093/gigascience/giae005/7629842?login=true.

To explore Metabox 2.0 more, an online web version is available at http://metsysbio.com/metabox. This breakthrough promises to revolutionize the field of metabolomics, providing researchers with enhanced data analysis and interpretation capabilities.

Unveiling Insights: Clinical Study on Allergic Rhinitis Patients

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We are delighted to announce the publication of a groundbreaking clinical study in Frontiers in Public Health, section Environmental Health and Exposome, on March 28th, 2024. Authored by Sirirat Aud-In, Yotin Juprasong, Bannapuch Pinkaew, Kanokporn Talek, Pongsakorn Tantilipikorn, and Wisuwat Songnuan, the study, “Incidence of grass and weed sensitization in Bangkok, Thailand: a clinical study,” delves into crucial insights.

This study aims to assess patterns of pollen sensitization in Thai allergic rhinitis patients while exploring correlations between demographics or clinical data and skin prick testing results. To access the online publication and delve deeper into the findings, please click here: http://journal.frontiersin.org/article/10.3389/fpubh.2024.1301095/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Public_Health&id=1301095.

This research represents a significant stride forward in understanding and addressing allergic rhinitis, paving the way for improved diagnosis and management strategies.

Celebrating Dr. Pannathee Prangtaworn’s Best Poster Award 2024

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March 27th, 2024, marks a momentous occasion. We extend our heartfelt congratulations to Dr. Pannathee Prangtaworn on receiving the prestigious Best Poster Award 2024 from the Allergy, Asthma, and Clinical Immunology Association of Thailand (AAIAT).

Dr. Prangtaworn’s outstanding achievement was recognized for his paper titled “Human IgE binding epitope identification of tropomyosin allergen (Per a 7) of American cockroach (Periplaneta americana),” representing the exceptional research conducted at the Siriraj Center of Research Excellence in Allergy and Immunology (SiCORE-Allergy). This accolade highlights Dr. Prangtaworn’s dedication and expertise and underscores SiCORE-Allergy’s commitment to advancing knowledge and innovation in allergy and immunology. Please join us in congratulating Dr. Pannathee Prangtaworn on this well-deserved honor.

For more Further Details, File:PDF file icon.svg - Wikipedia

Accurate Prediction of Ion Mobility Collision Cross-Section Using Ion’s Polarizability and Molecular Mass with Limited Data.

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We extend our congratulations to Dr. Pattipong Wisanpitayakorn and Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University, for their new research publication in the Journal of Chemical Information and Modeling on February 23, 2024. The publication can be accessed via this link:
https://pubs.acs.org/doi/full/10.1021/acs.jcim.3c01491.

In this study, the research team has identified and validated that ions’ polarizability and mass-to-charge ratio (m/z) exhibit the most significant predictive power for traveling-wave IM CCS values compared to other physicochemical properties of ions. Building upon this finding, the team demonstrated that a precisely predicted CCS database customized for each experimental setup can be constructed, even with limited datasets. These discoveries bolster confidence in compound annotation via ion mobility mass spectrometry, offering substantial benefits to metabolomics and lipidomics research.
Furthermore, this article was selected as the supplementary cover for the March 11, 2024, issue of the Journal of Chemical Information and Modeling, accessible at https://pubs.acs.org/toc/jcisd8/64/5

The ‘Ideasphere Meeting’ with Siriraj Center of Research for Excellence

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On March 18th, 2024, Siriraj Center of Research for Excellence Management (SiCORE-M), along with Siriraj’s esteemed research centers, including the Siriraj Center of Research for Excellence in Allergy and Immunology (SiALL), Siriraj Center of Research for Excellence in Dengue and Emerging Pathogens (SiCORE-Dengue), Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology (SiCORE-PM&SP), Siriraj Center of Research Excellence in Cardiovascular Disease (SiCORE-CVD), Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), and Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB), convened for their monthly meeting called, ‘Ideasphere Meeting‘, at the Faculty of Medicine Siriraj Hospital. The purpose of this gathering was to discuss and shape research questions and themes. Specifically, the focus of this meeting was on refining research methodologies related to diabetes and obesity under the guidance of Prof. Prasert Auewarakul, M.D., Ph.D., and the SiCORE-M team. We express our sincere gratitude to all the researchers for generously contributing their time and insightful comments.

The Ideasphere meeting, initiated by SiCORE-M at the beginning of 2024, aims to foster collaboration by inviting high-potential researchers from the Siriraj Center of Research for Excellence Network, as well as master researchers from other research groups within Siriraj, to collectively address research questions. Since its inception in January 2024, this meeting has been held four times, with the most recent gathering taking place in March 2024.

Breakthrough Research Published in Computational and Structural Biotechnology Journal

We are thrilled to announce the publication of groundbreaking research by Dr. Narumol Jariyasopit and Dr. Sakda Khoomrung from Siriraj Center of Research Excellence in Metabolomics and Systems Biology, Faculty of Medicine Siriraj Hospital, Mahidol University in the prestigious Computational and Structural Biotechnology Journal, Volume 21, 2023. Titled “Mass spectrometry-based analysis of gut microbial metabolites of aromatic amino acids,” the paper delves into pioneering insights into the intricate world of gut microbial metabolites. This significant contribution promises to reshape our understanding of the interactions between aromatic amino acids and gut microbiota.

We invite you to delve deeper into the details of this transformative study by accessing the publication directly through this Link: https://www.sciencedirect.com/science/article/pii/S2001037023003446. or scan QR code in the picture.

#SiCORE-MSB #SiCORE-M

 

Siriraj Visiting Scholars at the Research Department

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Prof. Dr. Pa-Thai Yenchitsomanus, Director of Siriraj Center of Research Excellence for Cancer Immunotherapy; Asst. Prof. Dr. Muttita Junking, Head Division of Molecular Medicine, Research Department; and Assoc. Prof. Prapat Wanitpongpan, Deputy Dean for Corporate Communication and International Relations, extended a warm welcome to Prof. George S. Baillie from the University of Glasgow, UK, specializing in Therapeutic Peptides and CAR-T Cell Technology. Prof. Baillie, an esteemed researcher, to serve as the visiting scholar at the Research Department from March 4th to 8th, 2024.

Siriraj Faculty Appointed to the Scientific Committee of the Metabolomics Society

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We are delighted to extend our heartfelt congratulations to Assoc. Prof. Dr. Sakda Khoomrung from the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University.

Assoc. Prof. Dr. Khoomrung has been selected to serve on the Scientific Organizing Committee (SOC) tasked with developing the scientific program for the 20th Annual Conference of the Metabolomics Society in Osaka, Japan, from June 16th to 20th, 2027.

For more details, please visit the link: https://www.metabolomics2024.org/scientific-committee

Exploring Frontiers: Inaugural Teleconference with the Scientific Advisory Board of SiCORE-Metabolomic and Systems Biology

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On Monday, February 19, 2024, the Center of Research Excellence and the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB) had the distinct honor of engaging in a fruitful discussion with Emeritus Professor Jeremy Nicholson, Pro Vice Chancellor of Health Sciences and Executive Director of the Australian National Phenome Centre (ANPC) at Murdoch University, who serves as a member of the Scientific Advisory Board (SAB) in SiCORE-MSB. Joining him were his esteemed colleagues: Professor Julien Wist, Deputy Director of the ANPC, and Professor Elaine Holmes, Head of Computational and Systems Medicine at the ANPC.

Representing the Deputy Dean for Research and Innovation, Faculty of Medicine, Siriraj Hospital, Assist. Prof. Dr. Woraphat Ratta-apha, Head of the Center of Research Excellence, and Prof. Oranee Sanmaneechai, Assoc. Prof. Prawej Mahawithitwong and Assist. Prof. Tachjaree Panchalee Boonbowornpong, Deputy Head of the Center of Research Excellence, actively participated and provided introductions during the meeting.

The teleconference delved into comprehensive discussions regarding the group’s research direction, accompanied by presentations of research outcomes by Assoc. Prof. Dr. Sakda Khoomrung, the Director of SiCORE-MSB. The Center of Research Excellence extends our profound appreciation to Emeritus Professor Jeremy Nicholson and two representatives from ANPC for their outstanding support and active involvement. We eagerly anticipate continued opportunities for engaging in meetings in the future.

For further details, please visit our Facebook page: [Link]
#SiCORE-M #SiCORE-MSB

The Journal Inside Precision Medicine: Aiming AI at Cancer-Related Biomarkers

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We extend our congratulations to Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University, for being featured and referenced in the recent issue of the Journal Inside Precision Medicine on February 12, 2024.

The article, penned by Mike May, PhD., delves into the groundbreaking advancements in utilizing artificial intelligence (AI) to target cancer-related biomarkers. Dr. Khoomrung’s work, particularly the CRISP (Contour ROI Identification, Simulation, and Analysis in Imaging Metabolomics), a deep learning architecture for GC × GCTOFMS contour ROI identification, simulation and analysis, is highlighted as a significant contribution to this field. Moreover, the article draws insights from esteemed researchers across leading institutes worldwide, including Peking University, Tokyo Institute of Technology, Tel Aviv University, and Massachusetts General Hospital/Harvard Medical School.

For a comprehensive understanding, we encourage you to explore the detailed findings in the Journal Inside Precision Medicine (https://www.insideprecisionmedicine.com/topics/informatics/aiming-ai-at-cancer-related-biomarkers/)

#SiCORE-M #SiCORE-MSB