Immunology on infectious diseases

Assist.Prof.Dr.Wiwit Tantibhedhyangkul (M.D., Ph.D.)
Assist.Prof.Dr.Patimaporn Wongprompitak (Ph.D.)

Our Research is focusing on the characterization of IFN-g-specific autoreactive T cell in patients with anti-IFM-gamma autoantibody production. We are also interested in the interaction of innate immune cells and B cells during mycobacterial infection in these patients. In addition, we have been studying the innate immunity against several pathogens. Moreover, we have developed the diagnostic tests for tropical infectious diseases.

Research Interest

Research Interest

T cell and B cell response in patients with anti-IFN-gamma autoantibody production
Innate immunity in infectious diseases: scrub typhus, leptospirosis, and pythiosis
Development of diagnostic tests for infectious diseases

Publications

Key publications

Tantibhedhyangkul W, Wongsawat E, Matamnan S, Inthasin N, Sueasuay J, Suputtarnongkol Y. Anti-Mycoplasma Activity of Daptomycin and Its Use for Mycoplasma Elimination in Cell Cultures of Rickettsiae. Antibiotics (Basel). 2019 Aug 21;8(3):123. Doi: 10.3390/antibiotics8030123.
Tantibhedhyangkul W, Wongsawat E, Silpasakorn S, Waywa D, Saenyasiri N, Sueasuay J, Thipmontree W, Suputtarnongkol Y. Use of Multiplex Real-Time PCR To Diagnose Scrub Typhus. J Clin Microbiol. 2017 May;55(5):1377-1387. doi: 10.1128/JCM.02181-16.
Wongprompitak P, Pleewan N, Tantibhedhyangkul W, Chaiprasert A, Prabhasawat P, Inthasin N, Ekpo P. Involvement of Toll-like receptor 2 on human corneal epithelium during an infection of Pythium insidiosum. Asian Pac J Allergy Immunol. 2020 Jun;38(2):129-138. Doi: 10.12932/AP-110518-0311.
Inthasin N, Boonwong C, Matamnan S, Sueasuay J, Wongprompitak P, Tanttibhedhyangkul W, Ekpo P. Toll-like receptor 2-mediated induction of human beta-defensin 2 expression by Leptospira interrogans in human kidney cells. Asian Pac J Allergy Immunol. 2020 Oct 17. doi: 10.12932/AP-010420-0798.
Tantibbhedhyangkul W, Wongsawat E, Chongtrakool P, Tiengrim S, Thaipadungpanit J, Suputtamongkol Y. Case Recovery of Pathogenic Leptospira spp. From Routine Aerobic Blood Culture Bottles. Am J Trop Med Hyg. 2020 Nov;103(5):1834-1837. doi: 10.4269/ajtmh.20-0204. Sep;17(3)491-503. doi: 10.1007/s10561-016-9575-4.
Tantibbhedhyangkul W, Matamnan S, Longkunan A, Boonwong C, Knowawisetsut L. Endothelial Activation in Orientia tsutsugamushi Infection Is Mediated by Cytokine Secretion From Infected Monocytes. Front Cell Infect Microbiol. 2021 Jul 22;11:683017.

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