Decoding the Cell Cycle: How a Key Protein Influences Cell Fate and Cancer Treatment

Every day, billions of cells in our body divide, grow and repair tissue, ensuring our health and survival. This process, known as the cell cycle, is tightly regulated to prevent errors. When these controls fail, diseases like cancer—where cells divide uncontrollably—can arise.

At the heart of this regulation is FOXM1, a crucial protein that acts as a conductor, directing cells through different stages of the cycle. While FOXM1’s role in normal cell growth is well established, its behavior in individual cells—especially under conditions of disruption—has remained a mystery.

Our latest study uncovers how FOXM1 responds to different cellular conditions, offering new insights into its role in cancer development and potential therapeutic strategies. Understanding this mechanism brings us one step closer to more precise cancer treatments.

🔬 Read the full research highlight here: https://www.sisyspharm.org/highlights/decoding-the-cell-cycle-how-a-key-protein-shapes-cell-fate-and-cancer-treatment

 

Siriraj Faculty Abroad at the 8th International Conference on Multifunctional, Hybrid and Nanomaterials in France

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Kamonlatth Rodponthukwaji, PhD, a researcher from the Research Department at Siriraj Hospital, Faculty of Medicine, Mahidol University, attended and presented a poster at the 8th International Conference on Multifunctional, Hybrid and Nanomaterials held in Montpellier, France, from March 3rd to 6th, 2025. Dr. Rodponthukwaji presented a poster titled “Development of a targeted dual-ligand liposomal system to improve therapeutic efficacy against mutant glioblastoma”.

Dr. Rodponthukwaji’s participation will benefit Siriraj Hospital by fostering research collaborations, increasing academic recognition, and advancing nanomedicine applications. Through engagement with leading experts and institutions, the hospital can establish new partnerships for joint research, secure funding opportunities, and facilitate technology transfer. The insights gained from the conference can drive innovation in diagnostics, drug delivery, and biomaterials, ultimately contributing to improved patient care.

Siriraj Faculty Abroad at the “8th International Conference on Multifunctional, Hybrid and Nanomaterials” in France

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Punnida Nonsuwan, PhD, a researcher from the Research Department at Siriraj Hospital, Faculty of Medicine, Mahidol University, attended and presented a poster at the 8th International Conference on Multifunctional, Hybrid and Nanomaterials held in Montpellier, France, from March 3rd to 6th, 2025.

Dr. Nonsuwan’s participation provided valuable insights into the latest advancements in nanomaterials and their medical applications for Siriraj. Engaging with cutting-edge research, Siriraj is poised to enhance its own research initiatives, particularly in nanomedicine, targeted drug delivery, and diagnostic technologies. Collaboration opportunities with leading researchers and institutions could catalyze new clinical trials, innovative research projects, and the development of advanced therapies. This exchange of knowledge aims to bolster Siriraj’s commitment to advancing medical research and improving patient care through emerging technologies.

Investigation of Southern Thailand Sweet Pickled Mango Metabolic Profiles Related to Deterioration

Congratulations to Dr. Niken Indrati and Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University, for their latest research publication in Food Chemistry on March 1, 2025.

Their study, “Investigation of Southern Thailand Sweet Pickled Mango Metabolic Profiles Related to Deterioration”, aimed to elucidate key metabolites linked to the deterioration of mango-based condiments (MBC) stored at 4°C (STR4) and 30°C (STR30). The results indicate that deterioration is associated with increased levels of ethyl acetate, isopropyl alcohol, trans-β-ocimene, isopentyl acetate, 2-phenethyl acetate, glucose, and fructose, alongside a decrease in sucrose. Notably, isopentyl acetate, ethyl acetate, and 2-phenethyl acetate were significantly higher in STR4 than in STR30, with log2[fold change (FC)] values of 3.2, 2.0, and 1.0, respectively. In contrast, sucrose levels in STR4 were lower than in STR30 (log[FC] -1.4), suggesting a longer storage-induced sucrose hydrolysis in STR4. Given the abundance of volatile metabolites in deteriorated MBC, the study proposes that applying odor- or flavor-absorbing films in MBC packaging could help prolong shelf life.

Read the full publication here: https://www.sciencedirect.com/science/article/pii/S0308814625009148

#SiCOREMSB #FoodChemistry #Metabolomics #ResearchExcellence #FoodScience

Siriraj Research Week 2025 Begins!

The Siriraj Research Week 2025, a significant event in our academic calendar, is now underway! The event, a testament to our collective commitment to research and innovation, is hosted by the Research and Innovation Department, Faculty of Medicine Siriraj Hospital, Mahidol University, from February 26th to 28th, 2025.

We were honored to welcome Prof. Apichat Asavamongkolkul, M.D., Dean of the Faculty of Medicine Siriraj Hospital, alongside Assoc. Prof. Sith Sathornsumetee, M.D., Deputy Dean for Research and Innovation, and Assist. Prof. Tara Vongviriyangkoon, M.D., Deputy Dean, visited the SiCORE-M Exhibition booth to explore ongoing research and innovations.

The first day saw an enthusiastic response, and we are eagerly anticipating even more participants in the coming days. Join us as we celebrate and advance research excellence at Siriraj!

#SirirajResearchWeek2025 #SiCOREM #ResearchInnovation #AdvancingScience

Featured Cover of “Multi-Pass Arrival Time Correction in Cyclic Ion Mobility Mass Spectrometry for Imaging and Shotgun Lipidomics”

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We extend our heartfelt congratulations to Dr. Pattipong Wisanpitayakorn and Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB), Faculty of Medicine, Siriraj Hospital, Mahidol University, for having their research featured on the cover of ACS Measurement Science Au.

Their study, “Multi-Pass Arrival Time Correction in Cyclic Ion Mobility Mass Spectrometry for Imaging and Shotgun Lipidomics,” presents a novel approach for improving lipidomics analysis, enhancing the accuracy of isomeric lipid identification.

🔹 Explore the Cover: https://pubs.acs.org/toc/amachv/5/1.
🔹 Read the Full Publication: https://pubs.acs.org/doi/full/10.1021/acsmeasuresciau.4c00077

This recognition highlights the groundbreaking contributions of SiCORE-MSB researchers in advancing mass spectrometry and metabolomics. Congratulations once again on this outstanding achievement!

ASEAN Researchers Visit Siriraj Medical Research Center (SiMR)

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On February 21st, 2025, Assoc. Prof. Sith Sathornsumetee, Deputy Dean of the Research Division, alongside esteemed teams from the Psychiatric Disorders Research Group, Health Policy Research Group, Siriraj Genomics, and the Siriraj Center of Research Excellence for Diabetes and Obesity Research (SiCORE-DO), welcome participants of the UK-SEA Workshop for Early-Career Health-Related Researchers in Thailand.

The visit featured an introduction to the center’s various research groups, followed by engaging discussions on ongoing initiatives. Guests also had the opportunity to tour the research facilities, gaining firsthand insight into cutting-edge projects and advancements in health-related research.

National Cheng Kung University Visits Siriraj

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On February 14th, 2025, the Faculty of Medicine Siriraj Hospital, Mahidol University, led by Prof. Apichat Asavamongkolkul, Dean; Assoc. Prof. Sith Sathornsumetee, Deputy Dean of Research and Innovation; Assoc. Prof. Thawornchai Limjindaporn, Deputy Dean of Postgraduate Education; Assoc. Prof. Prapat Wanitpongpan, Deputy Dean for Corporate Communication and International Relations; and Asst. Prof. Kamol Udol, Chair of the Department of Preventive & Social Medicine, welcomed a distinguished delegation from the College of Medicine, National Cheng Kung University (NCKU), Taiwan, on a visit and discussion on potential collaborations in medical research and education.

The NCKU delegation included Prof. Li-Wha Wu, Chairman of the Institute of Molecular Medicine; Prof. Fan-E Mo, Director of the Department of Cell Biology and Anatomy; Prof. Hsiu-Ling Chen, Director of the Department of Food Safety, Hygiene, and Risk Management; Prof. Pei Chen Lee, Director of the Department of Public Health; Associate Prof. Pei-Yun Lee, Department of Physical Therapy; Ms. Areeya Prasertsang, PhD student in the Department of Nursing; Prof. Dr. Waranun Buajeeb, Director of the NCKU Overseas Hub in Thailand; Dr. Binit Shrestha, Commissioner; Asst. Prof. Dulyapong Rungraungrayabkul, Commissioner; and Ms. Kranravee Keawsuk, Assistant Secretary.

During the visit, the delegation toured key research facilities at the Siriraj Medical Research Building, including Siriraj Genomics, the Medical Bioinformatics Lab, and the Molecular Medicine Research Center.

Siriraj Faculty Abroad at the 2nd TBRN International Conference

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Ms. Amphun Chaiboonchoe, PhD, a Research Scientist from the Siriraj Center of Research Excellence in Precision Medicine and Systems Pharmacology (SiCORE-PM&SP), participated in the 2nd Thailand Bioinformatics Research Network (TBRN) International Conference held in Bangkok, Thailand, from January 22nd to 24th, 2025. Ms. Chaiboonchoe presented a poster titled “Exploring Tumor Microenvironment-Dependent Heterogeneity in Colorectal Cancer through Spatial Transcriptomics and Gene Expression Platforms.”

The TBRN conference served as a platform to explore the latest advancements in bioinformatics methodologies, significantly enriching cancer research efforts at Siriraj Hospital. It fostered collaborations with leading institutions, bolstering clinical translational research and capacity building. Moreover, the event underscored the critical role of integrating bioinformatics into clinical workflows, emphasizing potential funding opportunities for translational research driven by bioinformatics.

Special Talk on International Research Grant

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   Special Talk on International Research Grant (การขอทุนวิจัยต่างประเทศ);

Siriraj Research Week: Advancing Research to Benefit Global Health System

 

   Date: February 27th, 2025

Time: 01:00 p.m. – 04:00 p.m.

Venue: Sirindhorn room, Chalermphrakiet Building, Faculty of Medicine Siriraj Hospital

 

    Speaker: Prof. Dr. Banchob Sripa, Director of the Tropical Disease Research Center, Faculty of Medicine, Khon Kaen University

 

   Registration for free at QR Code

 

If you need any additional information, please contact us (SiCORE-M).

 Tel. 02-419-2900 or E-mail: sicore.management@gmail.com

#SiCOREM #SiCOREs #ResearchGrant #SirirajResearchWeek