Institutional Visit to Explore Strategic Research Management: Faculty of Pharmacy, Mahidol University at Faculty of Medicine Siriraj Hospital

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On April 30th, 2024, the Faculty of Pharmacy, Mahidol University, embarked on a visit to explore the management systems at the Faculty of Medicine Siriraj Hospital, Mahidol University. This collaborative initiative aims to facilitate the exchange of knowledge and solutions about management systems in education, service, and research. We extend our heartfelt appreciation for the warm welcome the executive team from the Faculty of Pharmacy received.

We are incredibly grateful for the honor bestowed upon us by Assoc. Prof. Sith Sathornsumetee, Deputy Dean of Research and Innovation, led the discussions. Our sincere thanks also go to Asst. Prof. Woraphat Ratta-apha, Head of the Center of Research Excellence, provided a brief introduction of our strategic unit; Prof. Oranee Sanmaneechai, Deputy Head, and Ms. Sarinya Ngamtipvatana, Head of the Research Department, who actively participated in the discussions.

We eagerly look forward to future visits and opportunities for collaboration, as we continue our collective journey towards excellence in research management.

Acknowledging the Editorial Role of Assoc. Prof. Dr. Sakda Khoomrung

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We proudly acknowledge and extend our congratulations to Assoc. Prof. Dr. Sakda Khoomrung, from the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine, Siriraj Hospital, Mahidol University. Dr. Khoomrung has been appointed to the Editorial Board of the Computational and Structural Biology Journal, contributing expertise in a wide array of disciplines, including Mass Spectrometry, Imaging Mass Spectrometry, Metabolomics, Gut Microbial Metabolites, Bioinformatics, Systems Biology, Biochemistry, Precision Medicine, Chronic Kidney Disease, and Cancers. For those interested in delving deeper into the intricacies of these fields, we encourage you to explore the detailed findings in the Computational and Structural Biology Journal, accessible via this link: https://www.sciencedirect.com/journal/computational-and-structural-biotechnology-journal/about/editorial-board

This appointment further solidifies Dr. Khoomrung’s dedication and expertise in advancing scientific research. Meanwhile, it underscores the excellence of SiCORE-MSB in contributing to the scientific community.

Inaugural Teleconference: SiCORE-M Engages with Research and Innovation Advisory Committee (RIAC)

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SiCORE-M held an inaugural teleconference with a newly joined member of the Research and Innovation Advisory Committee (RIAC) on April 2nd, 2024. We are pleased to announce the confirmation of Distinguished Professor Nipon Chattipakorn, M.D., Ph.D., Director of the Cardiac Electrophysiology Research and Training Center (CERT Center) at the Faculty of Medicine, Chiang Mai University, as a member of the RIAC committee.

The purpose of this meeting was to welcome Professor Nipon and provide a brief introduction to SiCORE and research management at the Faculty of Medicine Siriraj Hospital. We sought guidance for shaping our direction and plans for 2024. In this regard, we extend our sincere appreciation to Professor Nipon for accepting the invitation to serve on the RIAC committee and look forward to his valuable insights and contributions alongside our esteemed existing members.

SiCORE-MSB Teleconference with Scientific Advisory Board member: Mapping the Future of SiCORE-MSB Research

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On March 25th, 2024, the SiCORE-M Team and SiCORE-MSB convened a pivotal teleconference with one of the esteemed Scientific Advisory Board (SAB) members of the SiCORE-MSB, Prof. Anil K. Agarwal, Chief of Medicine at VA Central California Health Care System and Professor of Medicine at the University of California San Francisco, engaged in two insightful sessions.

Session 1, “Introduction of SiCORE-M,” Assist. Prof. Dr. Woraphat Ratta-apha, Head of the Center of Research Excellence, warmly welcomed Prof. Anil K. Agarwal and presented the term of reference for the SAB.

In Session 2, “Discussing the Research Question and Direction of SiCORE-MSB,” Assoc. Prof. Dr. Sakda Khoomrung, Director of SiCORE-MSB, alongside his team members, including Assist. Prof. Sukit Raksasuk, Dr. Narumol Jariyasopit, and Dr. Kwanjeera Wanichthanarak presented their research questions, plans, and strategies for discussion and feedback from the SAB. This collaborative effort signifies a crucial step towards shaping the future trajectory of research within SiCORE-MSB, fostering innovation and excellence in metabolomic and systems biology endeavors.

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Introducing Metabox 2.0: Advancing Quantitative Metabolomics

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Exciting news! Dr. Kwanjeera Wanichthanarak and Assoc. Prof. Dr. Sakda Khoomrung from the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine, Siriraj Hospital, Mahidol University, have just published groundbreaking research in the Journal of GigaScience on March 15, 2024.

Their study, focusing on data processing solutions to enhance the quantitative nature of metabolomics, offers invaluable insights for both food and clinical metabolomics. By evaluating various data processing methods, including an examination of data distribution characteristics and fold difference patterns between metabolites, the team has introduced Metabox 2.0. This powerful tool facilitates thorough metabolomic data analysis, from processing to biomarker analysis, integrative analysis, and data interpretation.

Access the publication here: https://academic.oup.com/gigascience/article/doi/10.1093/gigascience/giae005/7629842?login=true.

To explore Metabox 2.0 more, an online web version is available at http://metsysbio.com/metabox. This breakthrough promises to revolutionize the field of metabolomics, providing researchers with enhanced data analysis and interpretation capabilities.

Unveiling Insights: Clinical Study on Allergic Rhinitis Patients

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We are delighted to announce the publication of a groundbreaking clinical study in Frontiers in Public Health, section Environmental Health and Exposome, on March 28th, 2024. Authored by Sirirat Aud-In, Yotin Juprasong, Bannapuch Pinkaew, Kanokporn Talek, Pongsakorn Tantilipikorn, and Wisuwat Songnuan, the study, “Incidence of grass and weed sensitization in Bangkok, Thailand: a clinical study,” delves into crucial insights.

This study aims to assess patterns of pollen sensitization in Thai allergic rhinitis patients while exploring correlations between demographics or clinical data and skin prick testing results. To access the online publication and delve deeper into the findings, please click here: http://journal.frontiersin.org/article/10.3389/fpubh.2024.1301095/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Public_Health&id=1301095.

This research represents a significant stride forward in understanding and addressing allergic rhinitis, paving the way for improved diagnosis and management strategies.

Celebrating Dr. Pannathee Prangtaworn’s Best Poster Award 2024

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March 27th, 2024, marks a momentous occasion. We extend our heartfelt congratulations to Dr. Pannathee Prangtaworn on receiving the prestigious Best Poster Award 2024 from the Allergy, Asthma, and Clinical Immunology Association of Thailand (AAIAT).

Dr. Prangtaworn’s outstanding achievement was recognized for his paper titled “Human IgE binding epitope identification of tropomyosin allergen (Per a 7) of American cockroach (Periplaneta americana),” representing the exceptional research conducted at the Siriraj Center of Research Excellence in Allergy and Immunology (SiCORE-Allergy). This accolade highlights Dr. Prangtaworn’s dedication and expertise and underscores SiCORE-Allergy’s commitment to advancing knowledge and innovation in allergy and immunology. Please join us in congratulating Dr. Pannathee Prangtaworn on this well-deserved honor.

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Accurate Prediction of Ion Mobility Collision Cross-Section Using Ion’s Polarizability and Molecular Mass with Limited Data.

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We extend our congratulations to Dr. Pattipong Wisanpitayakorn and Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University, for their new research publication in the Journal of Chemical Information and Modeling on February 23, 2024. The publication can be accessed via this link:
https://pubs.acs.org/doi/full/10.1021/acs.jcim.3c01491.

In this study, the research team has identified and validated that ions’ polarizability and mass-to-charge ratio (m/z) exhibit the most significant predictive power for traveling-wave IM CCS values compared to other physicochemical properties of ions. Building upon this finding, the team demonstrated that a precisely predicted CCS database customized for each experimental setup can be constructed, even with limited datasets. These discoveries bolster confidence in compound annotation via ion mobility mass spectrometry, offering substantial benefits to metabolomics and lipidomics research.
Furthermore, this article was selected as the supplementary cover for the March 11, 2024, issue of the Journal of Chemical Information and Modeling, accessible at https://pubs.acs.org/toc/jcisd8/64/5

The ‘Ideasphere Meeting’ with Siriraj Center of Research for Excellence

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On March 18th, 2024, Siriraj Center of Research for Excellence Management (SiCORE-M), along with Siriraj’s esteemed research centers, including the Siriraj Center of Research for Excellence in Allergy and Immunology (SiALL), Siriraj Center of Research for Excellence in Dengue and Emerging Pathogens (SiCORE-Dengue), Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology (SiCORE-PM&SP), Siriraj Center of Research Excellence in Cardiovascular Disease (SiCORE-CVD), Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), and Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB), convened for their monthly meeting called, ‘Ideasphere Meeting‘, at the Faculty of Medicine Siriraj Hospital. The purpose of this gathering was to discuss and shape research questions and themes. Specifically, the focus of this meeting was on refining research methodologies related to diabetes and obesity under the guidance of Prof. Prasert Auewarakul, M.D., Ph.D., and the SiCORE-M team. We express our sincere gratitude to all the researchers for generously contributing their time and insightful comments.

The Ideasphere meeting, initiated by SiCORE-M at the beginning of 2024, aims to foster collaboration by inviting high-potential researchers from the Siriraj Center of Research for Excellence Network, as well as master researchers from other research groups within Siriraj, to collectively address research questions. Since its inception in January 2024, this meeting has been held four times, with the most recent gathering taking place in March 2024.

Breakthrough Research Published in Computational and Structural Biotechnology Journal

We are thrilled to announce the publication of groundbreaking research by Dr. Narumol Jariyasopit and Dr. Sakda Khoomrung from Siriraj Center of Research Excellence in Metabolomics and Systems Biology, Faculty of Medicine Siriraj Hospital, Mahidol University in the prestigious Computational and Structural Biotechnology Journal, Volume 21, 2023. Titled “Mass spectrometry-based analysis of gut microbial metabolites of aromatic amino acids,” the paper delves into pioneering insights into the intricate world of gut microbial metabolites. This significant contribution promises to reshape our understanding of the interactions between aromatic amino acids and gut microbiota.

We invite you to delve deeper into the details of this transformative study by accessing the publication directly through this Link: https://www.sciencedirect.com/science/article/pii/S2001037023003446. or scan QR code in the picture.

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