Decoding the Cell Cycle: How a Key Protein Influences Cell Fate and Cancer Treatment

Every day, billions of cells in our body divide, grow and repair tissue, ensuring our health and survival. This process, known as the cell cycle, is tightly regulated to prevent errors. When these controls fail, diseases like cancer—where cells divide uncontrollably—can arise.

At the heart of this regulation is FOXM1, a crucial protein that acts as a conductor, directing cells through different stages of the cycle. While FOXM1’s role in normal cell growth is well established, its behavior in individual cells—especially under conditions of disruption—has remained a mystery.

Our latest study uncovers how FOXM1 responds to different cellular conditions, offering new insights into its role in cancer development and potential therapeutic strategies. Understanding this mechanism brings us one step closer to more precise cancer treatments.

🔬 Read the full research highlight here: https://www.sisyspharm.org/highlights/decoding-the-cell-cycle-how-a-key-protein-shapes-cell-fate-and-cancer-treatment

 

Investigation of Southern Thailand Sweet Pickled Mango Metabolic Profiles Related to Deterioration

Congratulations to Dr. Niken Indrati and Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University, for their latest research publication in Food Chemistry on March 1, 2025.

Their study, “Investigation of Southern Thailand Sweet Pickled Mango Metabolic Profiles Related to Deterioration”, aimed to elucidate key metabolites linked to the deterioration of mango-based condiments (MBC) stored at 4°C (STR4) and 30°C (STR30). The results indicate that deterioration is associated with increased levels of ethyl acetate, isopropyl alcohol, trans-β-ocimene, isopentyl acetate, 2-phenethyl acetate, glucose, and fructose, alongside a decrease in sucrose. Notably, isopentyl acetate, ethyl acetate, and 2-phenethyl acetate were significantly higher in STR4 than in STR30, with log2[fold change (FC)] values of 3.2, 2.0, and 1.0, respectively. In contrast, sucrose levels in STR4 were lower than in STR30 (log[FC] -1.4), suggesting a longer storage-induced sucrose hydrolysis in STR4. Given the abundance of volatile metabolites in deteriorated MBC, the study proposes that applying odor- or flavor-absorbing films in MBC packaging could help prolong shelf life.

Read the full publication here: https://www.sciencedirect.com/science/article/pii/S0308814625009148

#SiCOREMSB #FoodChemistry #Metabolomics #ResearchExcellence #FoodScience

Siriraj Research Week 2025 Begins!

The Siriraj Research Week 2025, a significant event in our academic calendar, is now underway! The event, a testament to our collective commitment to research and innovation, is hosted by the Research and Innovation Department, Faculty of Medicine Siriraj Hospital, Mahidol University, from February 26th to 28th, 2025.

We were honored to welcome Prof. Apichat Asavamongkolkul, M.D., Dean of the Faculty of Medicine Siriraj Hospital, alongside Assoc. Prof. Sith Sathornsumetee, M.D., Deputy Dean for Research and Innovation, and Assist. Prof. Tara Vongviriyangkoon, M.D., Deputy Dean, visited the SiCORE-M Exhibition booth to explore ongoing research and innovations.

The first day saw an enthusiastic response, and we are eagerly anticipating even more participants in the coming days. Join us as we celebrate and advance research excellence at Siriraj!

#SirirajResearchWeek2025 #SiCOREM #ResearchInnovation #AdvancingScience

Featured Cover of “Multi-Pass Arrival Time Correction in Cyclic Ion Mobility Mass Spectrometry for Imaging and Shotgun Lipidomics”

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We extend our heartfelt congratulations to Dr. Pattipong Wisanpitayakorn and Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB), Faculty of Medicine, Siriraj Hospital, Mahidol University, for having their research featured on the cover of ACS Measurement Science Au.

Their study, “Multi-Pass Arrival Time Correction in Cyclic Ion Mobility Mass Spectrometry for Imaging and Shotgun Lipidomics,” presents a novel approach for improving lipidomics analysis, enhancing the accuracy of isomeric lipid identification.

🔹 Explore the Cover: https://pubs.acs.org/toc/amachv/5/1.
🔹 Read the Full Publication: https://pubs.acs.org/doi/full/10.1021/acsmeasuresciau.4c00077

This recognition highlights the groundbreaking contributions of SiCORE-MSB researchers in advancing mass spectrometry and metabolomics. Congratulations once again on this outstanding achievement!

Special Talk on International Research Grant

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   Special Talk on International Research Grant (การขอทุนวิจัยต่างประเทศ);

Siriraj Research Week: Advancing Research to Benefit Global Health System

 

   Date: February 27th, 2025

Time: 01:00 p.m. – 04:00 p.m.

Venue: Sirindhorn room, Chalermphrakiet Building, Faculty of Medicine Siriraj Hospital

 

    Speaker: Prof. Dr. Banchob Sripa, Director of the Tropical Disease Research Center, Faculty of Medicine, Khon Kaen University

 

   Registration for free at QR Code

 

If you need any additional information, please contact us (SiCORE-M).

 Tel. 02-419-2900 or E-mail: sicore.management@gmail.com

#SiCOREM #SiCOREs #ResearchGrant #SirirajResearchWeek

 

International Grant Workshop

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On December 26, 2024, the Siriraj Center of Research Excellence Management (SiCORE-M) hosted an International Grant Workshop at Room 201, 2nd Floor, Srisavarindira Building, Faculty of Medicine Siriraj Hospital. The workshop featured esteemed speakers, including Research Prof. Dr. Jetsumon (Sattabongkot) Prachumsri, Assoc. Prof. Dr. Thomas Guadamuz and the MU-SURF Team from Mahidol University.

The workshop aimed to enhance participants’ knowledge and skills in applying for international research grants. It covered essential topics such as crafting practical research grant proposals, providing participants with actionable strategies, and included personalized advice for proposals submitted by participants, empowering them to tailor their proposals effectively.

The Faculty of Medicine Siriraj Hospital extends our heartfelt gratitude to the speakers for their invaluable contributions and looks forward to organizing similar impactful events. We will eagerly encourage all participants to stay tuned for future opportunities.

 

Executive Team Visits SiCORE-MSB Operations

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On December 17th, 2024, Professor Apichat Asavamongkolkul, Dean of the Faculty of Medicine Siriraj Hospital, along with Assoc. Prof. Sith Sathornsumetee, Deputy Dean for Research and Innovation, Assistant Professor Woraphat Ratta-Apha, Head of the Center of Research Excellence, and Miss Sarinya Ngamtipvatana, Head of the Research Department, visited the operations of SiCORE-MSB and SiMPC at the 10th-floor meeting room of the Srisavarindira Building.

During the visit, the SiCORE-MSB team showcased their research equipment and technological capabilities, provided updates on their progress, and addressed challenges related to their technology platforms. The meeting fostered a collaborative discussion on future directions, strategic plans, and milestones to enhance the center’s impact and mission. The engagement reflected a shared commitment to driving research excellence and innovation.

Multi-Pass Arrival Time Correction in Cyclic Ion Mobility Mass Spectrometry for Imaging and Shotgun Lipidomics

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Congratulations to Dr. Pattipong Wisanpitayakorn, Dr. Narumol Jariyasopit, and Assoc. Prof. Dr. Sakda Khoomrung of the Siriraj Center of Research Excellence in Metabolomic and Systems Biology (SiCORE-MSB), Faculty of Medicine Siriraj Hospital, Mahidol University, on their latest research publication in the Journal of ACS Measurement Science Au on December 19, 2024. Access the publication via this link:
https://pubs.acs.org/doi/10.1021/acsmeasuresciau.4c00077

This groundbreaking study tackles the challenge of identifying isomeric and isobaric lipids in lipidomics using direct infusion mass spectrometry (DI-MS) and mass spectrometry imaging (MSI) without chromatographic separation. The researchers present a multipass arrival time correction method that works across varying conditions and laboratories, allowing precise annotation of isomeric lipids with a single measurement. This streamlined approach reduces complexity compared to traditional methods. Validation using serum samples demonstrated no matrix effects and minimized drift time differences from over 2% to below 0.2%, irrespective of condition variations.

We celebrate this achievement and its contribution to advancing lipidomics research.

Final Ideasphere Meeting of 2024 with Siriraj Centers of Research Excellence

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On December 9th, 2024, the Siriraj Center of Research Excellence Management (SiCORE-M), together with Siriraj’s distinguished research centers—including the Siriraj Center of Research for Excellence in Allergy and Immunology (SiALL), Siriraj Center of Research for Excellence in Dengue and Emerging Pathogens (SiCORE-Dengue), Siriraj Center of Research Excellence for Precision Medicine and Systems Pharmacology (SiCORE-PM&SP), Siriraj Center of Research Excellence in Cardiovascular Disease (SiCORE-CVD), Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), and Siriraj Center of Research Excellence in Metabolomics and Systems Biology (SiCORE-MSB)—held the final Ideasphere Meeting of 2024 at the Faculty of Medicine Siriraj Hospital.

The meeting focused on the theme, “Collaborative Research Projects on Metabolomic Disease, Metabolic Disease, and iPSC,” under the guidance of Prof. Prasert Auewarakul, M.D., Ph.D., and the SiCORE-M team. We extend our heartfelt gratitude to all participating researchers for their valuable time and insightful contributions, fostering collaboration and innovation across disciplines.

Executive Team Visits SiCORE-PM&SP Operations

On November 19th, 2024, Professor Apichat Asavamongkolkul, Dean of the Faculty of Medicine Siriraj Hospital, together with Assoc. Prof. Sith Sathornsumetee, Deputy Dean for Research and Innovation, Assistant Professor Woraphat Ratta-Apha, Head of the Center of Research Excellence, Professor Oranee Sanmaneechai, Deputy Head, and Miss Sarinya Ngamtipvatana, Head of the Research Department, visited the operations of SiCORE-PM&SP at the 11th-floor meeting room on the Srisavarindira Building.

During the visit, the SiCORE-PM&SP team provided updates on their research progress and discussed challenges related to cancer research in precision medicine and systems pharmacology. The meeting also explored future directions and strategic plans to advance the center’s mission and impact.