สาระความรู้ CoP แผลและออสโตมี (Wound and Ostomy)
Ulcerative lesion management in hematologic patient receiving chemotherapy

Pattiya Chuasrakoo,
Untika Wutidilokprapan
Siriraj Hospital, Mahidol University, Thailand

Febrile neutropenia and skin problems are often associated with chemotherapy. As cytarabine is considered one of the most important drugs for the treatment of AML, it is important to be aware of complications that may occur in patients treated with this drug. That is a cause of severe dermatological toxicity; bullous erythema, painful, swelling and toxic epidermal necrolysis had been described after the use of high-dose cytarabine. Skin changes are supposed to be dose-related and occur more frequently
with high-dose regimens (Brandt et al., 2010). Febrile neutropenia represents a clinically important complication that can impact the outcome of hematologic patients receiving chemotherapy (Busca & De Rosa, 2015) and increases risk for infection. Moreover, in a case received chemotherapy, febrile neutropenia due to infections were found to be the most common cause of skin lesions that is difficult-to-treat.

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